- [Tumors of the paranasal sinus invading the orbit]. [Review]
- HNOHNO 2018 Aug 16
- Invasion of the orbit by tumors of the paranasal sinus represents an advanced state of disease. Prognosis has hardly improved in recent decades, despite multimodal therapeutic approaches. Complete re...
Invasion of the orbit by tumors of the paranasal sinus represents an advanced state of disease. Prognosis has hardly improved in recent decades, despite multimodal therapeutic approaches. Complete resection of the tumor still remains the most promising therapy. Orbital exenteration implies a dramatic event for the patient's psyche and quality of life. If the eye that would have to be exenterated is the only one remaining with sufficient vision, exenteration should be abandoned in consensus with the patient. Aesthetic improvements following exenteration can be achieved by surgical and prosthetic techniques. The method of prosthesis fixation needs to be determined with respect to the patients' individual expectations and manual abilities. The main aspects of functional rehabilitation are good local cleanability and sufficient nasal breathing without encrusted mucus, which can be achieved by restoring the natural laminar airflow. Tumors of the paranasal sinus with orbital invasion represent a diagnostic and therapeutic challenge. The information regarding prognosis, therapeutic approaches, post-therapeutic quality of life, and rehabilitation options should be thoroughly discussed by patients and therapists prior to treatment.
- The epidemiology, treatment, and determinants of outcome of primary head and neck cancers at the Jos University Teaching Hospital. [Journal Article]
- SASouth Asian J Cancer 2018 Jul-Sep; 7(3):183-187
- CONCLUSIONS: HNC constitutes almost a quarter of head and neck tumors affecting twice the number of males in their sixth decade with nasopharyngeal cancers being the most common in both genders. Several modifiable variables are noted to target appropriate future cancer education for lifestyle modification, screening for early detection and treatment.
- Primary Sphenoidal Sinus Lymphoma with Initial Presentation as Unilateral Abducens Nerve Palsy Symptom. [Journal Article]
- CRCase Rep Neurol Med 2018; 2018:5305963
- A 48-year-old man presented with 3 days of mild horizontal diplopia in the left direction, followed by the onset of headache 17 days later. A physical examination revealed isolated left abducens nerv...
A 48-year-old man presented with 3 days of mild horizontal diplopia in the left direction, followed by the onset of headache 17 days later. A physical examination revealed isolated left abducens nerve palsy. Head computed tomography (CT) and magnetic resonance imaging (MRI) scans revealed soft-tissue density neoplasms that occupied the sphenoidal sinus and further invaded to destroy the clivus. Immunohistochemical staining of neoplasms was performed from biopsies samples. The pathological diagnosis was extranodal natural killer (NK)/T-cell lymphoma (ENKL), nasal type, associated with Epstein-Barr virus (EBV). The patient subsequently exhibited secondary symptoms (fever, night sweats), enlarged lymph nodes, renal metastases, and hemophagocytic syndrome, with clinical diagnosis stage IV of ENKL. The patient has a poor prognosis. This report is unique in two aspects: the unilateral abducens nerve palsy as the initial and isolated symptom of ENKL, and the primary sphenoidal sinus ENKL.
- Expression of T-cell receptor signalling pathway components in extranodal NK/T-cell lymphoma. [Journal Article]
- HHistopathology 2018 Aug 13
- CONCLUSIONS: Although some ENTKL cases were polyclonal for TCR gene rearrangement and others lacking TCR protein expression, we speculate that TCR pathway might be functioning in ENKTLs. T vs. NK-signature might be better in delineating the physiology of ENKTL than cellular lineage. ITK might be a potential therapeutic target for patients with ITK-expressing tumours. This article is protected by copyright. All rights reserved.
- Primary surgical treatment of nasal vestibule cancer - therapeutic outcome and reconstructive strategies. [Journal Article]
- RRhinology 2018 Aug 15
- CONCLUSIONS: Surgery in SCCNV gives an excellent prognosis and minimized the need for radiotherapy.
- New perspectives in the therapeutic approach of peripheral T-cell lymphoma. [Journal Article]
- COCurr Opin Oncol 2018; 30(5):285-291
- CONCLUSIONS: Treatment remains a challenge for PTCL, and several targeted drugs provide new approaches. Progress will be made incrementally in the different subtypes. One of the critical situations facing new drugs is the ability to run robust clinical trials in rare diseases.
- Ultrahigh dose-rate radiotherapy: Next steps for FLASH-RT. [Journal Article]
- CCClin Cancer Res 2018 Aug 09
- A new way of delivering radiotherapy at very high dose-rates is described and compared to conventional radiotherapy. The ultrahigh dose-rate therapy reduces damage to normal pig skin and exerts poten...
A new way of delivering radiotherapy at very high dose-rates is described and compared to conventional radiotherapy. The ultrahigh dose-rate therapy reduces damage to normal pig skin and exerts potent activity against spontaneous nasal tumours in cat patients. The implications for clinical development of this approach are discussed.
- [iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas]. [Journal Article]
- RKRinsho Ketsueki 2018; 59(7):932-938
- Extranodal natural killer (NK) /T-cell lymphoma (ENKL), nasal-type, is an aggressive lymphoma that is relatively common in Asia and is resistant to anthracycline-based chemotherapy. Antigen-specific ...
Extranodal natural killer (NK) /T-cell lymphoma (ENKL), nasal-type, is an aggressive lymphoma that is relatively common in Asia and is resistant to anthracycline-based chemotherapy. Antigen-specific cytotoxic T-lymphocyte (CTL) therapy can induce durable remission in selected tumors, such as melanomas and virus-related tumors. ENKLs are commonly infected with the Epstein-Barr virus (EBV) ; therefore, CTL therapy can be effective for these lymphomas. However, CTLs that are continuously exposed to viral or tumor antigens usually get exhausted. Antigen-specific CTLs generated from iPSCs have a higher proliferative capacity and longer telomeres than original CTLs and are functionally rejuvenated (rejuvenated T cell, rejT). For clinical translation, the tumorigenic potential of iPSCs and the malignant transformation of differentiated iPSCs are major safety concerns. To address these issues, we introduced inducible caspase-9 (iC9) -based safeguard system into iPSCs. iC9-rejTs exert strong anti-tumor effects against EBV-infected tumors in vivo, and the iC9 suicide gene system provides a reliable safeguard for rejT therapy. We initiated a preclinical study using this novel immunotherapy for EBV-associated lymphoma. We believe that rejT therapy can be a potential safe approach as an "off-the-shelf" therapy for refractory ENKL in the future.
- Postauricular Melanocytic Neuroectodermal Tumor of Infancy: A Rare Site of a Rare Tumor-MNTI as a Postauricular Mass with Literature Review. [Journal Article]
- CRCase Rep Otolaryngol 2018; 2018:9829856
- Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare osteolytic neoplasm of neural crest cell origin. There are less than 500 documented cases, most frequently affecting the maxilla of infan...
Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare osteolytic neoplasm of neural crest cell origin. There are less than 500 documented cases, most frequently affecting the maxilla of infants less than 1 year old. We present a unique case of a two-month-old male with a progressive postauricular mass since birth, confirmed to be a MNTI. The lesion required three resections over the course of five months, with rapid recurrence ultimately requiring a craniectomy, highlighting the difficulty in treating these tumors. Histological and radiographic features were reviewed; an updated literature review for identifying and treating these lesions is presented.
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- Sinonasal organising haematoma - a little known entity. [Journal Article]
- BJBraz J Otorhinolaryngol 2018 Jul 17
- CONCLUSIONS: Awareness of this relatively new clinical entity and its evaluation and treatment is important for otolaryngologists, maxillofacial surgeons and pathologists alike. Despite the clinical picture of malignancy, histopathological features of benign disease can safely dispel such a diagnosis.