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2,657 results
  • Cardiovascular Drug Administration Errors During Neuraxial Anesthesia or Analgesia-A Narrative Review. [Review]
    J Cardiothorac Vasc Anesth. 2022 Oct 26 [Online ahead of print]Patel S
  • The prevalence and harm associated with inadvertent neuraxial cardiovascular (CV) medication administration errors are unknown. This review aims to analyze neuraxial CV drug administration errors and associated clinical consequences. The secondary objective is to identify the causes and contributory factors in order to prevent future incidents. The author reviewed reports of accidental administra…
  • Hypertensive Conditions: Hypertensive Disorders in Pregnancy. [Journal Article]
    FP Essent. 2022 Nov; 522:25-33.Kipnis CM, Daly PL, … Smith DK
  • Hypertensive disorders in pregnancy (HDP) represent a spectrum of disease that affect women through pregnancy and the immediate postpartum period. These conditions are associated with significant morbidity and mortality during and after pregnancy and have been linked to cardiovascular disease later in life. The HDP spectrum includes gestational hypertension (HTN), preeclampsia, eclampsia, HELLP (…
  • Beta-adrenergic receptor blockade in angiosarcoma: Which beta-blocker to choose? [Journal Article]
    Front Oncol. 2022; 12:940582.Embaby A, van Merendonk L, … Huitema A
  • Beta-blockers are currently studied to improve therapeutic options for patients with angiosarcoma. However, most of these patients have no cardiovascular co-morbidity and it is therefore crucial to discuss the most optimal pharmacological properties of beta-blockers for this population. To maximize the possible effectiveness in angiosarcoma, the use of a non-selective beta-blocker is preferred ba…
  • Hypertensive Crisis in Pregnancy. [Review]
    Obstet Gynecol Clin North Am. 2022 Sep; 49(3):501-519.Wautlet CK, Hoffman MC
  • Severe hypertension in pregnancy is a medical emergency, defined as systolic blood pressure (BP) ≥ 160 mm Hg and/or diastolic BP ≥ 110 mm Hg taken 15 minutes to 4 or more hours apart. Outside pregnancy, acute severe hypertension (HTN) is defined as a BP greater than 180/110 to 120 reproducible on 2 occasions. The lower threshold for severe HTN in pregnancy reflects the increased risk for adverse …
  • Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. [Review]
    Eur J Clin Pharmacol. 2022 Nov; 78(11):1763-1776.van de Vusse D, Mian P, … Versmissen J
  • CONCLUSIONS: We conclude that despite decades of prescribing methyldopa, labetalol, and nifedipine throughout pregnancy, descriptions of their PK during pregnancy are hampered by a large heterogeneity in the low number of available studies. Aiming for evidence-based and personalized dosing of antihypertensive medication in the future, further studies on the relationship of both PK and pharmacodynamics (including the optimal blood pressure targeting) during pregnancy and pregnancy-related pathology are urgently needed to prevent undertreatment, overtreatment, and side effects.
  • Identification of potentially irritating intravenous medications. [Journal Article]
    Enferm Intensiva (Engl Ed). 2022 Jul-Sep; 33(3):132-140.Ballesteros-Peña S, Fernández-Aedo I, … Miguelez C
  • CONCLUSIONS: Knowing the pH and osmolarity of intravenous drugs allows their capacity to cause endothelial damage to be assessed. The use of comprehensive tables based on the chemical properties of the drugs can be a useful tool to help prevent chemically-induced phlebitis.
  • Unusual Presentation of Postprandial Sinus Tachycardia in Pregnancy. [Case Reports]
    Cureus. 2022 Jun; 14(6):e26425.Stavros S, Pinon AM, … Khamvongsa P
  • This report describes the clinical presentation and systematic workup of a 25-year-old primigravid woman presenting at 34 weeks gestation with symptoms of postprandial sinus tachycardia. Differentials included pregnancy-related inappropriate sinus tachycardia (PRIST) and swallowing-induced atrial tachycardia. PRIST has favorable outcomes for both the mother and baby, although the symptoms can be …
  • StatPearls: Deadly Single Dose Agents [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EuwemaMichael S.MSOrange Park Medical CenterSwansonTerrell J.TJOrange Park Medical CenterBOOK
  • Although the basics of evaluating and treating most unknown ingestants are well known, many overdoses require very specific treatment if the patient is to have any chance of survival.[1] Countless studies have been published supporting Dr. Gideon Koren's 1993 landmark article "Medications Which Can Kill a Toddler with One Tablet or Teaspoonful" in the Journal of Toxicology.[2][3][4][5] while each…
  • StatPearls: Labetalol [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)MillerMichaelMBAMCKerndtConnor C.CCSpectrum Health/Michigan State University College of Human MedicineMaaniChristopher V.CVUS ArmyBOOK
  • Due to their negative inotropic and chronotropic actions, beta-adrenergic receptor antagonists are typically indicated in individuals with chronic cardiovascular disease (hypertension, coronary artery disease, congestive heart failure) with a significant reduction in mortality. The FDA-approved indication for labetalol is to treat arterial hypertension, which ranges from acute hypertensive crises…
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