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291,729 results
  • The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis. [Journal Article]
  • OCOsteoarthritis Cartilage 2018 Sep 18
  • Guss JD, Ziemian SN, … Hernandez CJ
  • CONCLUSIONS: Severe obesity increased load-induced cartilage damage, while milder changes in adiposity/metabolic syndrome seen in TLR5KO mice did not. Furthermore, the effects of systemic inflammation/obesity on cartilage damage depend on the duration of mechanical loading. Lastly, reduced cartilage damage in the TLR5KOΔMicrobiota mice suggests that the gut microbiome may influence cartilage pathology.
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