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441,925 results
  • Significant Improvement in Blood Pressure Levels Among Older Adults With Hypertension in Rural South Africa. [Journal Article]
    Hypertension. 2023 Feb 08 [Online ahead of print]Ferro EG, Abrahams-Gessel S, … Gaziano TA
  • CONCLUSIONS: The hypertension prevalence and incidence are plateauing in this aging cohort. There was a statistically and clinically significant decline in mean blood pressure and a substantial increase in individuals with controlled hypertension on medication. The prevalence of cardiometabolic risk factors did not decrease over time, suggesting that the blood pressure decrease is likely due to increased medication access and adherence, promoted by local health systems.
  • Prevalence of overweight and obesity among health professionals with shift work schedules: A scoping review. [Review]
    Chronobiol Int. 2023 Feb 08 [Online ahead of print]Tavares Amaro MG, Conde de Almeida RA, … Negrato CA
  • Epidemiological evidence show that shift work can contribute to increased body weight. This study aims to map the prevalence of obesity and overweight among health professionals who work in shifts and analyse the factors that contribute to weight gain. A scoping review was conducted, following the proposal of the Joanna Briggs Institute. The Population, Concept, and Context strategy was used to f…
  • Tabersonine attenuates obesity-induced renal injury via inhibiting NF-κB-mediated inflammation. [Journal Article]
    Phytother Res. 2023 Feb 08 [Online ahead of print]Qian C, Wang J, … Cao S
  • Obesity-induced metabolic disorders can cause chronic inflammation in the whole body, activating the nuclear factor kappa B (NF-κB) pathway and inducing apoptosis. Therefore, anti-inflammatory strategies may be effective in preventing obesity-related renal injury. Tabersonine (Tab) has been used pharmacologically to alleviate inflammation-related symptoms. This study evaluated the therapeutic eff…
  • Targeting the mitochondrial Ca2+ uniporter complex in cardiovascular disease. [Review]
    Acta Physiol (Oxf). 2023 Feb 08 [Online ahead of print]Lozano O, Marcos P, … García-Rivas G
  • Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca2+ uptake dynamics through the mitochondrial Ca2+ uniporter (MCU) complex. In particular, Ca2+ uptake regulates the mitochondrial ATP production, mitochondrial dynamics, oxidative stress, and cell death. Therefore, modulating the activity of the MCU com…
  • Diabetic Foot Risk Assessment among Patients with Type 2 Diabetes in Kenya. [Journal Article]
    East Afr Health Res J. 2022; 6(2):196-202.Nduati JN, Gatimu SM, Kombe Y
  • CONCLUSIONS: Our results show high rates of obesity, and poor glycaemic control in patients with type 2 diabetes and 56.5% of patients are categorised as being a moderate-to-high risk for foot problems. This highlights the need for healthcare professionals and patients in Kenya to be sensitised regarding the importance of foot screening to prevent lower-extremity complications.
  • Effects of Melatonin Supplementation on the Aortic Wall in a Diet-Induced Obesity Rat Model. [Journal Article]
    Cureus. 2023 Jan; 15(1):e33333.Chivchibashi-Pavlova D, Stoyanov GS, Bratoeva K
  • Background Cardiovascular disease (CVD) is still the leading cause of death globally. Alterations in the arterial wall architecture predict CVD morbidity and mortality and are associated with other CVD risk factors. Aortic wall thickness is closely linked to short- and long-term CVD morbidity and mortality, even without pronounced atherosclerotic changes. Obesity increases the risk of a broad spe…
  • Women With Polycystic Ovary Syndrome: A Review of Susceptibility to Type 2 Diabetes. [Review]
    Cureus. 2023 Jan; 15(1):e33390.Layacha SY, Biswas DA
  • The polycystic ovarian syndrome affects many women today. Previous research has demonstrated a direct link between it and serious ailments such as type 2 diabetes, heart disease, and infertility. Originally thought to be a reproductive disorder, polycystic ovarian syndrome (PCOS) is now understood to be a metabolic and psychological disorder. Women of reproductive age suffering from PCOS undergo …
  • A Delayed Diagnosis of Myxedema Coma. [Case Reports]
    Cureus. 2023 Jan; 15(1):e33370.Williams C
  • A 58-year-old man without any personal or familial cardiac history presented to the emergency department with complaints of worsening left-sided chest pain that began at rest, described as a burning sensation and escalating to a 9/10 severity. He denied any personal or familial cardiac history but admitted that he had not been medically evaluated in approximately five years. His physical examinat…
  • Effect of Intermittent Fasting on Body Image Satisfaction and Appreciation Among Saudi Adults. [Journal Article]
    Cureus. 2023 Jan; 15(1):e33468.Dairi G, Alafghani R, … Noorwali E
  • Obesity remains a public health concern, and intermittent fasting (IF) is a popular strategy for weight loss that has gained considerable scientific and popular attention. However, weight control can affect body image. Poor body image and its impact on psychological well-being are linked to obesity in many individuals. Body appreciation is a crucial characteristic of positive body image. However,…
  • Effect of Motor Competence and Health-Related Fitness in the Prevention of Metabolic Syndrome Risk Factors. [Journal Article]
    Res Q Exerc Sport. 2023 Feb 07 [Online ahead of print]Pombo A, Cordovil R, … Luz C
  • Purpose: In the last decades we have seen an increase in sedentary behaviors and a decrease in physical activity in children when compared to past generations. This lifestyle is commonly associated with the development of clustering risk factors that define metabolic syndrome (MetS). Knowing that motor competence (MC) development can influence lifelong physical activity habits, it is reasonable t…
  • Risk factors combine in a complex manner in assessment for macrosomia. [Journal Article]
    BMC Public Health. 2023 Feb 07; 23(1):271.Wang YW, Chen Y, Zhang YJ
  • CONCLUSIONS: Macrosomia was related to several common, modifiable risk factors. Some factors have combined effects on macrosomia (e.g., pre-pregnancy overweight/obesity and diabetes), whereas gestational hypertension varies by maternal age. Strategies based on pre-pregnancy risk factors should be given more attention to reduce the burden of macrosomia.
  • Understanding the contemporary high obesity rate from an evolutionary genetic perspective. [Review]
    Hereditas. 2023 Feb 07; 160(1):5.Wu T, Xu S
  • The topic of obesity is gaining increasing popularity globally. From an evolutionary genetic perspective, it is believed that the main cause of the high obesity rate is the mismatch between environment and genes after people have shifted toward a modern high-calorie diet. However, it has been debated for over 60 years about how obesity-related genes become prevalent all over the world. Here, we r…
  • Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases. [Review]
    Biol Sex Differ. 2023 Feb 07; 14(1):4.Santos-Marcos JA, Mora-Ortiz M, … Camargo A
  • Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only …
  • Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer. [Review]
    J Transl Med. 2023 Feb 07; 21(1):94.Huang P, Fan X, … Xue F
  • Endometrial cancer (EC) is a common gynecological cancer that endangers women health. Although substantial progresses of EC management have been achieved in recent years, the incidence of EC still remains high. Obesity has been a common phenomenon worldwide that increases the risk of EC. However, the mechanism associating obesity and EC has not been fully understood. Metabolic reprogramming as a …
  • Adipokines at the crossroads of obesity and mesenchymal stem cell therapy. [Review]
    Exp Mol Med. 2023 Feb 07 [Online ahead of print]Pham DV, Nguyen TK, Park PH
  • Mesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract metabolic syndromes, including obesity and its comorbid disorders. However, its effectiveness is challenged by various factors in the obese environment that negatively impact MSC survival and function. The identification of these detrimental factors will provide opportunities to optimize MSC therapy for the treatm…
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