- Significant Improvement in Blood Pressure Levels Among Older Adults With Hypertension in Rural South Africa. [Journal Article]Hypertension. 2023 Feb 08 [Online ahead of print]H
- CONCLUSIONS: The hypertension prevalence and incidence are plateauing in this aging cohort. There was a statistically and clinically significant decline in mean blood pressure and a substantial increase in individuals with controlled hypertension on medication. The prevalence of cardiometabolic risk factors did not decrease over time, suggesting that the blood pressure decrease is likely due to increased medication access and adherence, promoted by local health systems.
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- Prevalence of overweight and obesity among health professionals with shift work schedules: A scoping review. [Review]Chronobiol Int. 2023 Feb 08 [Online ahead of print]CI
- Epidemiological evidence show that shift work can contribute to increased body weight. This study aims to map the prevalence of obesity and overweight among health professionals who work in shifts and analyse the factors that contribute to weight gain. A scoping review was conducted, following the proposal of the Joanna Briggs Institute. The Population, Concept, and Context strategy was used to f…
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- Tabersonine attenuates obesity-induced renal injury via inhibiting NF-κB-mediated inflammation. [Journal Article]Phytother Res. 2023 Feb 08 [Online ahead of print]PR
- Obesity-induced metabolic disorders can cause chronic inflammation in the whole body, activating the nuclear factor kappa B (NF-κB) pathway and inducing apoptosis. Therefore, anti-inflammatory strategies may be effective in preventing obesity-related renal injury. Tabersonine (Tab) has been used pharmacologically to alleviate inflammation-related symptoms. This study evaluated the therapeutic eff…
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- Targeting the mitochondrial Ca2+ uniporter complex in cardiovascular disease. [Review]Acta Physiol (Oxf). 2023 Feb 08 [Online ahead of print]AP
- Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca2+ uptake dynamics through the mitochondrial Ca2+ uniporter (MCU) complex. In particular, Ca2+ uptake regulates the mitochondrial ATP production, mitochondrial dynamics, oxidative stress, and cell death. Therefore, modulating the activity of the MCU com…
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- "It is in our hands-why wait until you are sick?": Perceptions about diabetes prevention of Latina mothers in Mexico and the United States. [Journal Article]Diabet Med. 2023 Feb 08 [Online ahead of print]DM
- CONCLUSIONS: Mothers sought to prevent Type 2 diabetes and live healthy lives, particularly, after receiving a diagnosis of gestational diabetes or when learning about their children's risks for Type 2 diabetes but perceived significant barriers to Type 2 diabetes prevention.
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- Prevalence and trends of adult overweight and obesity in Nigeria - A systematic review and meta-analysis. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):1-15.NJ
- CONCLUSIONS: The prevalence of obesity and overweight in Nigeria is high with a rising trend over the years. A Nigerian national health survey of non-communicable diseases especially the burden of overweight/obesity is recommended to through more light on the subject. There is need for concerted effort to tame the tide of rising obesity rates in Nigeria.
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- Diabetic Foot Risk Assessment among Patients with Type 2 Diabetes in Kenya. [Journal Article]East Afr Health Res J. 2022; 6(2):196-202.EA
- CONCLUSIONS: Our results show high rates of obesity, and poor glycaemic control in patients with type 2 diabetes and 56.5% of patients are categorised as being a moderate-to-high risk for foot problems. This highlights the need for healthcare professionals and patients in Kenya to be sensitised regarding the importance of foot screening to prevent lower-extremity complications.
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- Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV. [Journal Article]South Afr J HIV Med. 2022; 23(1):1452.SA
- CONCLUSIONS: Dolutegravir exposure was marginally lower in participants with obesity, but this is not clinically significant. Our findings suggest that there is no need to dose adjust dolutegravir in people with obesity.
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- A study of environmental factors affecting nutritional status among students of primary schools at Ulanga district, Tanzania. [Journal Article]Health Sci Rep. 2023 Feb; 6(2):e1089.HS
- CONCLUSIONS: Unsafe water, poor method of water purification, personal hygiene and high house status are related to nutritional status and majority of students were underweight. Proper sanitation of the drinking water should be promoted in the community to prevent water borne diseases in the children, mass education on person hygiene and proper method of water purification should be promoted.
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- Bronchial Asthma Exacerbation in the Emergency Department in a Saudi Pediatric Population: An Insight From a Tertiary Hospital in Riyadh, Saudi Arabia. [Journal Article]Cureus. 2023 Jan; 15(1):e33391.C
- Background Severe uncontrolled asthma in the pediatric population is a complicated disease and is considered a major challenge for pediatricians. Severe bronchial asthma in the pediatric population is related to significant morbidity and mortality. Children with complicated asthma are at a higher risk for unfavorable outcomes, including medication-associated adverse effects, severe life-threateni…
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- Effects of Melatonin Supplementation on the Aortic Wall in a Diet-Induced Obesity Rat Model. [Journal Article]Cureus. 2023 Jan; 15(1):e33333.C
- Background Cardiovascular disease (CVD) is still the leading cause of death globally. Alterations in the arterial wall architecture predict CVD morbidity and mortality and are associated with other CVD risk factors. Aortic wall thickness is closely linked to short- and long-term CVD morbidity and mortality, even without pronounced atherosclerotic changes. Obesity increases the risk of a broad spe…
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- Women With Polycystic Ovary Syndrome: A Review of Susceptibility to Type 2 Diabetes. [Review]Cureus. 2023 Jan; 15(1):e33390.C
- The polycystic ovarian syndrome affects many women today. Previous research has demonstrated a direct link between it and serious ailments such as type 2 diabetes, heart disease, and infertility. Originally thought to be a reproductive disorder, polycystic ovarian syndrome (PCOS) is now understood to be a metabolic and psychological disorder. Women of reproductive age suffering from PCOS undergo …
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- A Delayed Diagnosis of Myxedema Coma. [Case Reports]Cureus. 2023 Jan; 15(1):e33370.C
- A 58-year-old man without any personal or familial cardiac history presented to the emergency department with complaints of worsening left-sided chest pain that began at rest, described as a burning sensation and escalating to a 9/10 severity. He denied any personal or familial cardiac history but admitted that he had not been medically evaluated in approximately five years. His physical examinat…
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- Effect of Intermittent Fasting on Body Image Satisfaction and Appreciation Among Saudi Adults. [Journal Article]Cureus. 2023 Jan; 15(1):e33468.C
- Obesity remains a public health concern, and intermittent fasting (IF) is a popular strategy for weight loss that has gained considerable scientific and popular attention. However, weight control can affect body image. Poor body image and its impact on psychological well-being are linked to obesity in many individuals. Body appreciation is a crucial characteristic of positive body image. However,…
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- Effects of the application of a food processing-based classification system in obese women: A randomized controlled pilot study. [Journal Article]Nutr Health. 2023 Feb 07 [Online ahead of print]NH
- Background: Obesity is one of the major public health problems worldwide and contributes to the onset of many diseases, especially the ones related to the metabolic syndrome. The new Dietary Guidelines for the Brazilian population bring a new food classification based on food processing and prioritizes the consumption of fresh or minimally processed foods. Aim: This study analyzed the effects of …
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- Effect of Motor Competence and Health-Related Fitness in the Prevention of Metabolic Syndrome Risk Factors. [Journal Article]Res Q Exerc Sport. 2023 Feb 07 [Online ahead of print]RQ
- Purpose: In the last decades we have seen an increase in sedentary behaviors and a decrease in physical activity in children when compared to past generations. This lifestyle is commonly associated with the development of clustering risk factors that define metabolic syndrome (MetS). Knowing that motor competence (MC) development can influence lifelong physical activity habits, it is reasonable t…
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- Icos gene disruption in NOD mice elicits myositis associated with anti-troponin T3 autoantibodies. [Journal Article]Neuropathol Appl Neurobiol. 2023 Feb 07 [Online ahead of print]NA
- CONCLUSIONS: These data show that Icos-/- NOD mice represent a spontaneous model of myositis and the discovery of anti-TNNT3 aAb suggests a new autoantigen in this model.
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- Risk factors combine in a complex manner in assessment for macrosomia. [Journal Article]BMC Public Health. 2023 Feb 07; 23(1):271.BP
- CONCLUSIONS: Macrosomia was related to several common, modifiable risk factors. Some factors have combined effects on macrosomia (e.g., pre-pregnancy overweight/obesity and diabetes), whereas gestational hypertension varies by maternal age. Strategies based on pre-pregnancy risk factors should be given more attention to reduce the burden of macrosomia.
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- Understanding the contemporary high obesity rate from an evolutionary genetic perspective. [Review]Hereditas. 2023 Feb 07; 160(1):5.H
- The topic of obesity is gaining increasing popularity globally. From an evolutionary genetic perspective, it is believed that the main cause of the high obesity rate is the mismatch between environment and genes after people have shifted toward a modern high-calorie diet. However, it has been debated for over 60 years about how obesity-related genes become prevalent all over the world. Here, we r…
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- The association of dietary glycemic index and glycemic load with the risk of insomnia in the adult population. [Journal Article]BMC Nutr. 2023 Feb 07; 9(1):28.BN
- CONCLUSIONS: Our results revealed that greater adherence to dietary pattern with high GL could be increased the odds of insomnia in Iranian adults.
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- Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases. [Review]Biol Sex Differ. 2023 Feb 07; 14(1):4.BS
- Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only …
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- Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer. [Review]J Transl Med. 2023 Feb 07; 21(1):94.JT
- Endometrial cancer (EC) is a common gynecological cancer that endangers women health. Although substantial progresses of EC management have been achieved in recent years, the incidence of EC still remains high. Obesity has been a common phenomenon worldwide that increases the risk of EC. However, the mechanism associating obesity and EC has not been fully understood. Metabolic reprogramming as a …
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- Scoping literature review and focus groups with healthcare professionals on psychosocial and lifestyle assessments for childhood obesity care. [Journal Article]BMC Health Serv Res. 2023 Feb 07; 23(1):125.BH
- CONCLUSIONS: This study provides an overview of psychosocial and lifestyle factors that should be identified within the context of childhood obesity care, as they may contribute to the development and maintenance of obesity. The results highlight the importance of both what is assessed and how it is assessed. The results of this study can be used to develop practical tools for facilitating healthcare professionals in conducting a psychosocial and lifestyle assessment.
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- Longitudinal association between adiposity changes and lung function deterioration. [Journal Article]Respir Res. 2023 Feb 07; 24(1):44.RR
- CONCLUSIONS: Adiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes.
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- Developing a mortality risk prediction model using data of 3663 hospitalized COVID-19 patients: a retrospective cohort study in an Egyptian University Hospital. [Journal Article]BMC Pulm Med. 2023 Feb 07; 23(1):57.BP
- CONCLUSIONS: Patients with the identified mortality risk factors are to be prioritized for preventive and rapid treatment measures. With the provided prediction models, clinicians can calculate mortality probability for their patients. Presenting multiple and very generic models can enable clinicians to choose the one containing the parameters available in their specific clinical setting, and also to test the applicability of such models in a non-COVID-19 respiratory infection.
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- Trend Impact Analysis (TIA) of community-based futures study for pediatric obesity in Iran. [Journal Article]BMC Pediatr. 2023 Feb 08; 23(1):66.BPed
- CONCLUSIONS: It seems that measures such as the effective communication of policy makers, basic evaluation of the programs and policies related to the prevention of childhood obesity, and localization of the programs of international organizations for the prevention of obesity can greatly control the prevalence of childhood obesity.
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- Changes in sugar-sweetened beverage purchases across the price distribution after the implementation of a tax in Mexico: a before-and-after analysis. [Journal Article]BMC Public Health. 2023 Feb 07; 23(1):265.BP
- CONCLUSIONS: Our findings show purchase reductions in the middle-price SSBs, which represents ≈30% of the overall SSB purchases in urban Mexico. Future studies should be conducted to test if the redesign of the current the tax, by either doubling the tax amount or taxing sugar content, might reduce more effectively purchases across all SSBs.
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- Nomogram model for the risk of insulin resistance in obese children and adolescents based on anthropomorphology and lipid derived indicators. [Journal Article]BMC Public Health. 2023 Feb 07; 23(1):275.BP
- CONCLUSIONS: Three early warning factors, TG/HDL-c, TC/HDL-c, and LDL-c/HDL-c, were screened, which can effectively predict the risk of developing IR in obese children and adolescents, and the nomogram model has an eligible diagnostic value.
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- Influence of puberty on relationships between body composition and blood pressure: a cross-sectional study. [Journal Article]Pediatr Res. 2023 Feb 07 [Online ahead of print]PR
- CONCLUSIONS: Puberty moderated the relationships between FFM and SBPz/DBPz in analyses that separately modeled the contributions of age and sex. These data suggest that the FFM-DBPz association may potentially be impacted by increasing sex hormone concentrations during puberty.
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- Adipokines at the crossroads of obesity and mesenchymal stem cell therapy. [Review]Exp Mol Med. 2023 Feb 07 [Online ahead of print]EM
- Mesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract metabolic syndromes, including obesity and its comorbid disorders. However, its effectiveness is challenged by various factors in the obese environment that negatively impact MSC survival and function. The identification of these detrimental factors will provide opportunities to optimize MSC therapy for the treatm…
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