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(Opioid withdrawal)
9,253 results
  • Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. [Review]
  • CDCochrane Database Syst Rev 2018 Jun 05; 6:CD006332
  • Candy B, Jones L, … Stone P
  • CONCLUSIONS: In this update, the conclusions for naldemedine are new. There is moderate-quality evidence to suggest that, taken orally, naldemedine improves bowel function over two weeks in people with cancer and OIBD but increases the risk of adverse events. The conclusions on naloxone and methylnaltrexone have not changed. The trials on naloxone did not assess laxation at 24 hours or over two weeks. There is moderate-quality evidence that methylnaltrexone improves bowel function in people receiving palliative care in the short term and over two weeks, and low-quality evidence that it does not increase adverse events. There is a need for more trials including more evaluation of adverse events. None of the current trials evaluated effects in children.
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