- Pediatric Optic Neuritis and Other Demyelinating Optic Neuropathies. [Journal Article]
- IOInt Ophthalmol Clin 2018; 58(4):113-123
- Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis. [Journal Article]
- FCFront Cell Infect Microbiol 2018; 8:311
- Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation...
Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spinal cord demyelination is also induced following intranasal inoculation with neurotropic MHV strains, however much higher viral doses are required as compared to intracranial inoculation. Recently, it was shown that intranasal administration of low concentrations of proteins leads to significant, rapid accumulation of protein in the optic nerve and in the eye, with only low levels reaching spinal cord and other brain regions. Thus, we examined whether intranasal inoculation with MHV at doses equivalent to those given intracranially could induce optic neuritis-inflammation, demyelination and loss of retinal ganglion cells (RGCs) in the optic nerve with or without inducing spinal cord demyelination. Four week old male C57BL/6J mice were inoculated intracranially with the recombinant demyelinating strain RSA59, or intranasally with RSA59 or the non-demyelinating strain RSMHV2 as control. One month post-inoculation, mice inoculated intracranially with RSA59 had significant myelin loss in both spinal cord and optic nerves, with significant loss of RGCs as well, consistent with prior studies. As expected, intranasal inoculation with RSA59 failed to induce demyelination in spinal cord; however, it also did not induce optic nerve demyelination. No acute inflammation was found, and no viral antigen was detected, in the optic nerve or retina 1 day after inoculation. Results confirm the neurotropic effects of RSA59 following intracranial inoculation, and suggest that direct infection with axonal transport of virus from brain to spinal cord and optic nerve is required to induce demyelinating disease. These studies suggest that MHV does not selectively concentrate in optic nerve and retina to sufficient levels to induce demyelination following intranasal inoculation. Intracranial inoculation should continue to be considered a preferred method for studies of MHV-induced optic neuritis and central nervous system (CNS) demyelinating disease.
- Do eyes with and without optic neuritis in multiple sclerosis age equally? [Journal Article]
- NDNeuropsychiatr Dis Treat 2018; 14:2281-2285
- CONCLUSIONS: This study has shown that we do not need to exclude eyes with a history of ON from longitudinal studies of neurodegeneration in MS, provided that we use data outside of the frame of acute changes post-ON. Long-term changes of peripapillary retinal nerve fiber layer in ON and FL eyes are equal.
- Photophobia in multiple sclerosis. [Journal Article]
- MSMult Scler Relat Disord 2018 Sep 08; 26:55-57
- CONCLUSIONS: Further studies to investigate the pathophysiological mechanisms underlying photophobia in MS are needed.
- Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children. [Case Reports]
- DMDev Med Child Neurol 2018 Sep 17
- CONCLUSIONS: Isolated seizures in the absence of acute disseminated encephalomyelitis may be the index presentation for myelin oligodendrocyte glycoprotein antibody-associated demyelination.
- A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis. [Journal Article]
- BOBMC Ophthalmol 2018 Sep 14; 18(1):247
- CONCLUSIONS: The NMOSD-ON group had more pronounced RNFLT thinning and visual function impairment than the IDON group. MME prevalence was higher in NMOSD-ON and was associated with higher frequency of clinical relapses.
- Identifying a new subtype of multiple sclerosis. [Journal Article]
- NDNeurodegener Dis Manag 2018 Sep 14
- Dr Bruce Trapp and Dr Daniel Ontaneda speak to Laura Dormer, Commissioning Editor: Bruce D Trapp, PhD, is a Chair of the Department of Neurosciences at the Lerner Research Institute, Cleveland Clinic...
Dr Bruce Trapp and Dr Daniel Ontaneda speak to Laura Dormer, Commissioning Editor: Bruce D Trapp, PhD, is a Chair of the Department of Neurosciences at the Lerner Research Institute, Cleveland Clinic (OH, USA) and Professor of Molecular Medicine at Case Western Reserve University (OH, USA). Dr Trapp received his PhD from Loyola University Stritch School of Medicine in Chicago (IL, USA). Dr Trapp's research investigates the cause of neurological disability in multiple sclerosis patients, cellular mechanism of brain repair in neurodegenerative diseases and the molecular biology of myelination in the central and peripheral nervous systems. Daniel Ontaneda, MD, is a staff neurologist at the Cleveland Clinic Mellen Center for Multiple Sclerosis. Dr Ontaneda earned his MD from the Universidad Católica del Ecuador and MSc in clinical research from Case Western Reserve University. He completed a postdoctoral fellowship at Baylor College of Medicine, followed by neurology and neuroimmunology training at the Cleveland Clinic. His specialties include acute disseminated encephalomyelitis, Devic's disease (neuromyelitis optica), multiple sclerosis, neuroimmunology, optic neuritis and transverse myelitis.
- Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders. [Journal Article]
- MSMult Scler Relat Disord 2018 Sep 10; 26:1-7
- CONCLUSIONS: MOG autoimmunity in children has a wide clinical spectrum, tendency to relapse, and a favourable outcome compared with other relapsing demyelinating diseases.
- Optic Perineuritis Due to Tuberculosis. [Journal Article]
- JNJ Neuroophthalmol 2018 Sep 10
- A 30-year-old man experienced subacute peripheral visual field loss with preserved central vision in his right eye. He was diagnosed with optic perineuritis due to tuberculosis. Optic perineuritis is...
A 30-year-old man experienced subacute peripheral visual field loss with preserved central vision in his right eye. He was diagnosed with optic perineuritis due to tuberculosis. Optic perineuritis is an uncommon disorder and, at times, can be difficult to distinguish from optic neuritis. The differentiation can have significant impact on diagnostic testing and patient management.
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- Role of Plasma Exchange in the Management of Pediatric Optic Neuritis With Antibodies Against Myelin Oligodendrocyte Glycoprotein. [Letter]
- TATher Apher Dial 2018 Sep 10