- Co-activation during gait following anterior cruciate ligament reconstruction. [Journal Article]
- CBClin Biomech (Bristol, Avon) 2019 May 09; 67:153-159
- CONCLUSIONS: Individuals with ACLR displayed heightened co-activation during walking which was associated with biomechanical outcomes that have been linked to negative changes in joint health following ACLR. These data suggest that excessive co-activation may contribute to the mechanical pathogenesis of post-traumatic osteoarthritis. ClinicalTrials.gov Identifier: NCT02605876.
- Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. [Review]
- APAnn Phys Rehabil Med 2019 May 20
- CONCLUSIONS: Exercise significantly reduces pain and improves function, performance and QoL in people with knee and hip OA as compared with usual care at 8 weeks. The effects are maximal around 2 months and thereafter slowly diminish, being no better than usual care at 9 to 18 months. Participants with younger age, knee OA and not awaiting joint replacement may benefit more from exercise therapy. These potential determinants, identified by study-level analyses, may have implied ecological bias and need to be confirmed with individual patient data.
- Effect of Cane Use on Bone Marrow Lesion Volume in People with Medial Tibiofemoral Knee Osteoarthritis: Randomized Clinical Trial. [Journal Article]
- OCOsteoarthritis Cartilage 2019 May 20
- CONCLUSIONS: Daily use of a cane during walking for 3 months aiming to reduce knee joint loading did not change medial tibiofemoral BML volumes compared to no use of gait aids.
- Through-Thickness Patterns of Shear Strain Evolve in Early Osteoarthritis. [Journal Article]
- OCOsteoarthritis Cartilage 2019 May 20
- CONCLUSIONS: We propose that changes in through-thickness patterns of shear strain could provide sensitive biomarkers for early clinical detection of OA. The relative zonal recruitment of the deep zone decreases with progressing OA (OARSI grade) and microstructural remodeling (PLM-CO score), which do not consistently affect recruitment of the superficial and middle zones.
- Propagation of Microcracks in Collagen Networks of Cartilage Under Mechanical Loads. [Journal Article]
- OCOsteoarthritis Cartilage 2019 May 20
- CONCLUSIONS: The microcracks we initiated under low-energy impact loading increased in length and width during subsequent cyclic compression that simulated walking. The extent of this propagation depended on the combination of impact and cyclic compression. More broadly, the initiation and propagation of microcracks may characterize pathogenesis of osteoarthritis, and may suggest therapeutic targets for future studies.
- Chondroitin sulfate from sturgeon bone protects chondrocytes via inhibiting apoptosis in osteoarthritis. [Journal Article]
- IJInt J Biol Macromol 2019 May 20
- We have previously reported that chondroitin sulfate extracted from Sturgeon bone (CSSB) can alleviate the pain caused by osteoarthritis (OA) by reducing the expression of matrix metalloproteinases (…
We have previously reported that chondroitin sulfate extracted from Sturgeon bone (CSSB) can alleviate the pain caused by osteoarthritis (OA) by reducing the expression of matrix metalloproteinases (MMPs) and inflammatory factors (IL-1, TNF-α and PGE2). However, the mechanism of CSSB for treating OA remains unclear. As is generally accepted, these proteins and factors are regulated by chondrocyte apoptosis in OA. Thus, it is reasonable to hypothesize whether CSSB can inhibit cartilage degradation via regulating the process of apoptosis. In order to address this problem, chondrocytes were isolated and exposed to 1 mM hydrogen peroxide (H2O2)-treated to induce chondrocytes apoptosis for mimicking the OA microenvironment, and co-incubated with different concentration of CSSB (0, 50, 100, 200 and 400 μg/ml). Results showed that CSSB could increase cell survival, decrease DNA fragment rate and apoptosis rate, also protect mitochondrial and decrease the expression of caspase-3 and caspase-9. These results showed that CSSB ameliorates cartilage matrix damage via inhibiting chondrocytes apoptosis.
- Optimization of TGF-β1-transduced chondrocytes for cartilage regeneration in a 3D printed knee joint model. [Journal Article]
- PlosPLoS One 2019; 14(5):e0217601
- A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection. The need for arthrosco…
A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection. The need for arthroscopic application of the cells to simultaneously treat intra-articular pathologies of knee osteoarthritis is increasingly urgent. The purpose of this study was to optimize TGF-β1-transduced chondrocytes for arthroscopic application. The optimal composition of chondrocytes and thrombin was initially determined by measuring the consolidation time of a diverse ratio of chondrocytes and thrombin mixed with 1 ml of fibrinogen. The consolidation time of the diverse ratio of fibrinogen and atelocollagen mixed with the determined optimal ratio of chondrocytes and thrombin was evaluated. The mixture of the determined optimal ratio of TGF-β1-transduced chondrocytes, atelocollagen, fibrinogen, and thrombin was applied to the cartilage defect of the 3D printed knee joint model arthroscopically. The status of the mixture in the defect was then evaluated. Chondrogenic activities of TGF-β1-transduced chondrocytes mixed with atelocollagen were evaluated. The determined ratio of TGF-β1-transduced chondrocytes to thrombin was 8:2 and that of fibrin to atelocollagen was also 8:2. Excellent maintenance of conformation of the mixture of TGF-β1-transduced chondrocytes, atelocollagen, fibrinogen, and thrombin in the cartilage defect of the 3D printed knee joint model was observed arthroscopically. Increased chondrogenic activities were observed in the group of TGF-β1-transduced chondrocytes mixed with atelocollagen. TGF-β1-transduced chondrocytes can be applied arthroscopically to treat cartilage defects of the knee at an optimized mixing ratio of atelocollagen, fibrinogen, and thrombin.
- Reply to letter by Deng et al. "Could the levels of inflammation biomarkers predict OA? Comment on the article by Roemer FW et al." [Journal Article]
- ARArthritis Rheumatol 2019 May 23
- As explained in the methods-section, we chose to analyze the 2-year data in regard to inflammatory activity based on MRI and synovial biomarkers (and not earlier time points) as our aim was to captur…
As explained in the methods-section, we chose to analyze the 2-year data in regard to inflammatory activity based on MRI and synovial biomarkers (and not earlier time points) as our aim was to capture patients that experienced "prolonged" or chronic inflammation, which may be regarded as a potential risk factor for osteoarthritis (OA) development. Virtually all patients of an acute injury cohort (like the KANON patients) will exhibit acute post-traumatic inflammation in their injured knee to a various extent as manifested by marked changes on imaging (i.e. effusion, traumatic synovitis and haemarthrosis) or in biochemical parameters. This article is protected by copyright. All rights reserved.
- Arthrodesis of the metacarpophalangeal and metatarsophalangeal joints to treat osteoarthritis in 17 horses. [Journal Article]
- VSVet Surg 2019 May 23
- CONCLUSIONS: Arthrodesis of the MCP/MTP joint was associated with acceptable morbidity and good long-term outcomes in these 17 horses with OA refractory to medical management.The morbidity and prognosis after fetlock arthrodesis for OA seem more favorable than reported in horses treated with traumatic disruption of the suspensory apparatus.
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- In Asian women undergoing total knee arthroplasty, lower leg morphology in those with rheumatoid arthritis differed from those with osteoarthritis. [Journal Article]
- MRMod Rheumatol 2019 May 23; :1-14
- CONCLUSIONS: RA patients undergoing TKA had different leg morphology than OA patients. These findings have implications for surgical planning.