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(Osteoarthritis)
82,680 results
  • Co-activation during gait following anterior cruciate ligament reconstruction. [Journal Article]
  • CBClin Biomech (Bristol, Avon) 2019 May 09; 67:153-159
  • Blackburn T, Pietrosimone B, … Spang JT
  • CONCLUSIONS: Individuals with ACLR displayed heightened co-activation during walking which was associated with biomechanical outcomes that have been linked to negative changes in joint health following ACLR. These data suggest that excessive co-activation may contribute to the mechanical pathogenesis of post-traumatic osteoarthritis. ClinicalTrials.gov Identifier: NCT02605876.
  • Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. [Review]
  • APAnn Phys Rehabil Med 2019 May 20
  • Goh SL, Persson MS, … Zhang W
  • CONCLUSIONS: Exercise significantly reduces pain and improves function, performance and QoL in people with knee and hip OA as compared with usual care at 8 weeks. The effects are maximal around 2 months and thereafter slowly diminish, being no better than usual care at 9 to 18 months. Participants with younger age, knee OA and not awaiting joint replacement may benefit more from exercise therapy. These potential determinants, identified by study-level analyses, may have implied ecological bias and need to be confirmed with individual patient data.
  • Through-Thickness Patterns of Shear Strain Evolve in Early Osteoarthritis. [Journal Article]
  • OCOsteoarthritis Cartilage 2019 May 20
  • Maier F, Lewis CG, Pierce DM
  • CONCLUSIONS: We propose that changes in through-thickness patterns of shear strain could provide sensitive biomarkers for early clinical detection of OA. The relative zonal recruitment of the deep zone decreases with progressing OA (OARSI grade) and microstructural remodeling (PLM-CO score), which do not consistently affect recruitment of the superficial and middle zones.
  • Propagation of Microcracks in Collagen Networks of Cartilage Under Mechanical Loads. [Journal Article]
  • OCOsteoarthritis Cartilage 2019 May 20
  • Santos S, Emery N, … Pierce DM
  • CONCLUSIONS: The microcracks we initiated under low-energy impact loading increased in length and width during subsequent cyclic compression that simulated walking. The extent of this propagation depended on the combination of impact and cyclic compression. More broadly, the initiation and propagation of microcracks may characterize pathogenesis of osteoarthritis, and may suggest therapeutic targets for future studies.
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