- Fragility fracture of talar neck in an osteoporotic patient treated by posterior-to-anterior screw fixation under hindfoot endoscopy: a case report. [Case Reports]J Surg Case Rep. 2023 Feb; 2023(2):rjad029.JS
- Fragility fractures of the talar neck are extremely rare. Here, we describe a case of fragility fracture of the talar neck associated with osteoporosis in a 76-year-old female, who was treated by posterior-to-anterior screw fixation under hindfoot endoscopy. A 76-year-old female cleaner with a history of osteoporosis complained of pain in her right ankle when going downstairs. Radiological findin…
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- Abaloparatide Has the Same Catabolic Effects on Bones of Mice When Infused as PTH (1-34). [Journal Article]JBMR Plus. 2023 Feb; 7(2):e10710.JP
- Abaloparatide is a peptide analog of parathyroid hormone-related protein (PTHrP 1-34) and was approved in 2017 as the second osteoanabolic peptide for treating osteoporosis. We previously showed that intermittent abaloparatide is equally as effective as PTH (1-34). This study was designed to compare the catabolic effects of PTH (1-34) and abaloparatide on bone in young female wild-type mice. Two-…
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- The risk of osteopenia/osteoporosis and psoriatic disease: A systematic review. [Journal Article]Skin Health Dis. 2023 Feb; 3(1):e169.SH
- CONCLUSIONS: Putative risks of OPe and OP in both Ps and PsA are supported but not confirmed. Significant heterogeneity of reported data limits definitive conclusions in this meta-analysis. This review contributes to the further understanding of Ps as a multisystem disease and future management of potential comorbidities, but highlights key gaps in the literature. Further studies addressing standardised OP reporting, specific disease group characteristics comparing Ps with PsA, patient characteristics and medication use, are required in order to make more certain conclusions with greater clinical impact.
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- Myeloid Cells As a Promising Target for Brain-Bone Degenerative Diseases from a Metabolic Point of View. [Journal Article]Adv Biol (Weinh). 2023 Feb 07 [Online ahead of print]AB
- Brain and bone degenerative diseases such as Alzheimer's disease and osteoporosis are common in the aging population and lack efficient pharmacotherapies. Myeloid cells are a diverse group of mononuclear cells that plays important roles in development, immune defense, and tissue homeostasis. Aging drastically alters the expansion and function of myeloid cells, which might be a common pathogenesis…
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- Prediction of osteoporosis using radiomics analysis derived from single source dual energy CT. [Journal Article]BMC Musculoskelet Disord. 2023 Feb 07; 24(1):100.BM
- CONCLUSIONS: The clinical-radiomics model incorporating the radiomics signature and a clinical parameter had a good ability to predict osteoporosis based on dual-energy CT monoenergetic imaging.
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- PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products. [Journal Article]Cell Death Dis. 2023 Feb 07; 14(2):88.CD
- Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleotide phosphate oxidase (NOX)-derived reactive oxygen species (ROS) production, cause mitochondrial membrane potential (ΔΨm) depolarization, trigger the mitochondria-dependent intrinsic apoptos…
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- Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition. [Journal Article]ACS Appl Mater Interfaces. 2023 Feb 07 [Online ahead of print]AA
- Regeneration of periodontal tissue remains a challenge. Under periodontitis, osteoclasts are overactivated and bone loss occurs. We incorporated sodium alendronate (Alen), a medication commonly used to treat osteoporosis, into a supramolecular hydrogel system in order to create a novel biomaterial that would promote periodontal bone regeneration by inhibiting osteoclast overactivation. The Nap-Gl…
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- FCH-PET/CT in primary hyperparathyroidism with discordant/negative MIBI scintigraphy and ultrasonography. [Journal Article]J Clin Endocrinol Metab. 2023 Feb 08 [Online ahead of print]JC
- CONCLUSIONS: This study highlights the contribution of [18F]F-fluorocholine PET/CT in a well phenotyped cohort of normocalcemic patients with discordant or negative findings in MIBI scintigraphy and ultrasonography. However, negative imaging in nPHTP does not rule out the possibility of surgical cure by an experienced surgeon.
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- Interleukin 6 promotes BMP9-induced osteoblastic differentiation through Stat3/mTORC1 in mouse embryonic fibroblasts. [Journal Article]Aging (Albany NY). 2023 Feb 01; 15A
- Interleukin 6 (IL-6) plays a dual role in regulating bone metabolism, although the concrete mechanism is unclear. Bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic inducers, and a promising alternative for bone tissue engineering. The relationship between IL-6 and BMP9 in osteogenic differentiation remains to be elucidated, and the osteoblastic potential of BMP9 needs to be…
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- Nitric oxide is associated with fracture risk in Japanese women. [Journal Article]PLoS One. 2023; 18(2):e0280854.Plos
- Although nitric oxide (NO) is a known factor that regulates the bone physiology, few and discordant results have been obtained in human studies evaluating the effect of nitrates on bone health. We investigated for the relationship between serum NOx level and incident osteoporotic fracture rate prospectively in a cohort consisting of Japanese women. A total of 871 subjects (67.5 ± 10.8 y/o) were a…
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- Exercise training and bone mineral density in postmenopausal women: an updated systematic review and meta-analysis of intervention studies with emphasis on potential moderators. [Review]Osteoporos Int. 2023 Feb 07 [Online ahead of print]OI
- The aim of this systematic review and meta-analysis was (1) to determine exercise effects on bone mineral density (BMD) in postmenopausal women and (2) to address the corresponding implication of bone and menopausal status or supervision in postmenopausal women. A comprehensive search of eight electronic databases according to the PRISMA statement up to August 9, 2022, included controlled exercis…
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- Theranostic Approach for the Management of Osteoporosis. [Journal Article]Crit Rev Ther Drug Carrier Syst. 2023; 40(3):95-121.CR
- Osteoporosis (OP) is a bone-metabolic disorder, causing micro-architecture degeneration and a decrease in bone density. Nutritional deficiency, i.e., calcium, vitamin D, and hormonal imbalances are the primary cause for the occurrence of OP. Although conventional diagnostic techniques and therapies are available and found to be effective only at a later stage, though still lack prevention strateg…
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- Opportunistic screening for low bone density using abdominopelvic computed tomography scans. [Journal Article]Med Phys. 2023 Feb 07 [Online ahead of print]MP
- CONCLUSIONS: The fusion model, which combines two planes of CT images and electronic medical records data, outperformed individual models and provided a high, robust diagnostic performance for opportunistic screening of low bone density using contrast and non-contrast CT exams. This model could potentially improve bone health risk assessment with no additional cost. The model's handling of metal implants is an ongoing effort. This article is protected by copyright. All rights reserved.
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- Identification of a stem cell mediating osteoblast versus adipocyte lineage selection. [Preprint]Res Sq. 2023 Jan 26RS
- Most skeletal fragility disorders are characterized by bone loss with a concurrent gain in marrow adipocytes 1-8. This suggests that a cell that forms adipocytes at the expense of osteoblasts is central to the pathogenesis of skeletal disorders. However, this cellular point of bifurcation between adipocyte and osteoblast differentiation pathways remains unknown. Here, we identify a new cell type …
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- Social Isolation Causes Cortical and Trabecular Bone Loss in Adult Male, but not Female, C57BL/6J Mice. [Preprint]bioRxiv. 2023 Jan 28B
- Social isolation is a potent form of psychosocial stress and is a growing public health concern, particularly among older adults. Even prior to the onset of the COVID-19 pandemic, which has significantly increased the prevalence of isolation and loneliness, researchers have been concerned about a rising "epidemic" of loneliness. Isolation is associated with an increased risk for many physical and…
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- GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells. [Journal Article]Eur J Endocrinol. 2023 Jan 10; 188(1)EJ
- CONCLUSIONS: GIP inhibits bone resorption and improves survival of human osteoblasts, indicating that drugs targeting GIPR may impair bone resorption, whilst preserving bone formation.
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- Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis. [Journal Article]BMC Pulm Med. 2023 Feb 06; 23(1):55.BP
- CONCLUSIONS: Osteoporosis had an independent effect on all-cause mortality in hospitalized NCFB patients. Management of comorbidities, including bone health, is a critical aspect of treating NCFB patients.
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- Chondroitin sulfate alleviates osteoporosis caused by calcium deficiency by regulating lipid metabolism. [Journal Article]Nutr Metab (Lond). 2023 Feb 06; 20(1):6.NM
- The use of non-drug intervention for calcium deficiency has attracted attention in recent years. Although calcium carbonate is the preferred raw material for calcium supplementation, there are few reports on the mechanism of the combined action of chondroitin sulfate and calcium to alleviate osteoporosis from the perspective of gut microbiota and metabolomics. In this study, a rat model of osteop…
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- Allolobophora caliginosa coelomic fluid and extract alleviate glucocorticoid-induced osteoporosis in mice by suppressing oxidative stress and regulating osteoblastic/osteoclastic-related markers. [Journal Article]Sci Rep. 2023 Feb 06; 13(1):2090.SR
- Allolobophora calignosa (Ac) is a folk medicine for millennia, as it possesses many biological activities. This study aimed to investigate the chemo-preventive activity of A.calignosa coelomic fluid (AcCF) and A.calignosa extract (AcE) on glucocorticoid-induced osteoporosis (GIOP) in mice. Characterization and in vitro biological activity of AcE and AcCF has been assessed. Male CD-1 mice were sub…
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- Probiotics and Prebiotics: Any Role in Menopause-Related Diseases? [Review]Curr Nutr Rep. 2023 Feb 07 [Online ahead of print]CN
- The aim of this review is to provide an overview of the menopause-related changes in microbiota and their role in the pathogenesis of menopause-related diseases. In addition, evidence on probiotic supplementation as a therapeutic strategy is discussed.
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- Research progress on the extraction technology and activity study of Epimedium polysaccharides. [Review]Carbohydr Polym. 2023 Apr 15; 306:120602.CP
- More pharmacological effects of polysaccharides from traditional Chinese medicines have been discovered in recent years. Epimedium has been used for thousands of years as a traditional Chinese medicine in China. Water-soluble Epimedium polysaccharides is one of the main ingredients of Epimedium, which is one of the main active ingredients of Epimedium, mainly composed of mannose, rhamnose, galact…
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- Structural characterization and anti-osteoporosis effects of polysaccharide purified from Eucommia ulmoides Oliver cortex based on its modulation on bone metabolism. [Journal Article]Carbohydr Polym. 2023 Apr 15; 306:120601.CP
- EuOCP3, with a molecular weight of 38.1 kDa, is an acidic polysaccharide purified from Eucommia ulmoides Oliver cortex. Herein, we determined that the main backbone of EuOCP3 was predominantly composed of →4)-α-GalpA-(1 → 4)-α-GalpA-(1→, →4)-α-GalpA-(1 → 5)-α-Araf-(1→, →4)-α-GalpA-(1 → 2)-α-Rhap-(1→, and →4)-α-GalpA-(1 → 5)-α-Araf-(1 → 2)-α-Rhap-(1 → repeating blocks, which were connected by →2,3…
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- Incorporating FRAX® into a nurse-delivered integrated care review: a multi-method qualitative study. [Journal Article]BJGP Open. 2023 Feb 06 [Online ahead of print]BO
- CONCLUSIONS: The findings suggest that, with appropriate training including risk communication, practice nurses are likely to be confident to play a key role in conducting fracture risk assessments, but further work is needed to address the barriers identified.
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- FSHR activation through small molecule modulators: Mechanistic insights from MD simulations. [Journal Article]Comput Biol Med. 2023 Jan 24; 154:106588.CB
- Follicle-stimulating hormone receptor (FSHR) is a glycoprotein hormone receptor that plays a vital role in reproduction, cancer progression and osteoporosis. Owing to its therapeutic importance, several small molecule modulators have been identified by researchers through high throughput studies that usually include virtual screening of chemical libraries followed by in vitro validation through r…
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- Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways. [Journal Article]Biomed Pharmacother. 2023 Feb 04; 160:114347.BP
- The formation of osteoclasts and their hyperactive bone resorption are related to the aggregation of intracellular reactive oxygen species (ROS). Flavonoids, derived from plant active ingredients, can alleviate the symptoms of osteoporosis (OP). Isosinensetin (Iss) is a flavonoid with antioxidant effects obtained mainly from citrus fruits, and its effect on osteoclastogenesis has not been reporte…
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- Denosumab prevented periprosthetic bone resorption better than risedronate after total hip arthroplasty. [Journal Article]J Bone Miner Metab. 2023 Feb 06 [Online ahead of print]JB
- CONCLUSIONS: Denosumab is more effective in preventing periprosthetic bone resorption than risedronate in the proximal femur. It also increased BMD around the stem implant following THA.
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- Symptomatic fractures in systemic sclerosis: A case-control study. [Journal Article]
- This case-control study analyzed risk factors for symptomatic fractures in a group of 52 patients with systemic sclerosis compared with a group of 104 patients without fractures, matched for sex and age, who were attended at a single systemic sclerosis outpatient clinic from 2010 to 2020. Fractures affected predominantly vertebral (65.4%), rib (13.5%), and hip (7.7%) joints, while the mean age of…
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- Computed tomography predictors of adult spinal cord injury without radiographic abnormality. [Journal Article]
- CONCLUSIONS: Osteoporosis, osteophytes, canal stenosis and ligament calcification are the factors that predispose adults to SCIWORA. The final outcome seems to be poorer in cases of canal stenosis when compared with osteophytes and osteoporosis. NCCT findings can be used as an adjunct to MRI to predict clinical presentation, severity and recovery in adult SCIWORA.
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- Does Zoledronic Acid Provide a Good Clinical Outcome in Patients With Chronic Back Pain Associated With Vertebral Osteoporosis? [Journal Article]
- Background Osteoporosis is a chronic, progressive, systemic condition of the skeletal tissue that is characterized by reduced bone density, microarchitecture deterioration, and fragile bones, making osteoporotic fractures or fragility fractures more likely to occur. This condition often remains asymptomatic and undiagnosed until it presents with fragility fractures. The condition is associated wi…
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- Complications of patients with hematologic malignancies in a selected Iranian population. [Journal Article]
- CONCLUSIONS: Due to early onset of osteopenia and osteoporosis and the presence of dental and bone abnormalities in half of study population, early assessment of their clinical and radiographic condition can be helpful in the prevention and the early treatment of their oral complications.
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