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78,651 results
  • Is Vitamin D Supplementation Effective for Low Back Pain? A Systematic Review and Meta-Analysis. [Journal Article]
  • PPPain Physician 2018; 21(2):121-145
  • Zadro JR, Shirley D, … Ferreira PH
  • CONCLUSIONS: The overall quality of evidence was "very low" due to the poor methodological quality and small sample sizes of the included studies.Vitamin D supplementation is not more effective than placebo, no intervention, or other conservative/pharmacological interventions for LBP (based on very low quality evidence). These results are consistent, regardless of the type of LBP or vitamin D supplementation. Until well-designed and adequately powered clinical trials suggest otherwise, the prescription of vitamin D for LBP cannot be recommended. PROSPERO Registration No: CRD42016046874. = CRD42016046874.
  • The significant role of ATG5 in the maintenance of normal functions of Mc3T3-E1 osteoblast. [Journal Article]
  • EREur Rev Med Pharmacol Sci 2018; 22(5):1224-1232
  • Weng YM, Ke CR, … Zhou DS
  • CONCLUSIONS: ATG5 silence can lead to inhibition of osteoblast proliferation and differentiation. Moreover, it makes the cells easier to be damaged by oxidative stress, and it causes an increase in apoptosis. However, the overexpression of ATG5 strengthens the anti-oxidative capacity of osteoblasts and reduces apoptosis. ATG5 may be an effective target of anti-oxidative therapy for osteoporosis, which brings a new direction for the treatment of osteoporosis.
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