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Unbound Medicine.
(Osteoporosis)
102,345 results
  • Abaloparatide Has the Same Catabolic Effects on Bones of Mice When Infused as PTH (1-34). [Journal Article]
    JBMR Plus. 2023 Feb; 7(2):e10710.Le Henaff C, Finnie B, … Partridge NC
  • Abaloparatide is a peptide analog of parathyroid hormone-related protein (PTHrP 1-34) and was approved in 2017 as the second osteoanabolic peptide for treating osteoporosis. We previously showed that intermittent abaloparatide is equally as effective as PTH (1-34). This study was designed to compare the catabolic effects of PTH (1-34) and abaloparatide on bone in young female wild-type mice. Two-…
  • The risk of osteopenia/osteoporosis and psoriatic disease: A systematic review. [Journal Article]
    Skin Health Dis. 2023 Feb; 3(1):e169.Schauer A, Uthayakumar AK, … Bunker CB
  • CONCLUSIONS: Putative risks of OPe and OP in both Ps and PsA are supported but not confirmed. Significant heterogeneity of reported data limits definitive conclusions in this meta-analysis. This review contributes to the further understanding of Ps as a multisystem disease and future management of potential comorbidities, but highlights key gaps in the literature. Further studies addressing standardised OP reporting, specific disease group characteristics comparing Ps with PsA, patient characteristics and medication use, are required in order to make more certain conclusions with greater clinical impact.
  • Myeloid Cells As a Promising Target for Brain-Bone Degenerative Diseases from a Metabolic Point of View. [Journal Article]
    Adv Biol (Weinh). 2023 Feb 07 [Online ahead of print]Pang Y, Zhu S, … Gao J
  • Brain and bone degenerative diseases such as Alzheimer's disease and osteoporosis are common in the aging population and lack efficient pharmacotherapies. Myeloid cells are a diverse group of mononuclear cells that plays important roles in development, immune defense, and tissue homeostasis. Aging drastically alters the expansion and function of myeloid cells, which might be a common pathogenesis…
  • Nitric oxide is associated with fracture risk in Japanese women. [Journal Article]
    PLoS One. 2023; 18(2):e0280854.Shiraki M, Kuroda T, … Urano T
  • Although nitric oxide (NO) is a known factor that regulates the bone physiology, few and discordant results have been obtained in human studies evaluating the effect of nitrates on bone health. We investigated for the relationship between serum NOx level and incident osteoporotic fracture rate prospectively in a cohort consisting of Japanese women. A total of 871 subjects (67.5 ± 10.8 y/o) were a…
  • Theranostic Approach for the Management of Osteoporosis. [Journal Article]
    Crit Rev Ther Drug Carrier Syst. 2023; 40(3):95-121.Pant A, Singh J, … Singh B
  • Osteoporosis (OP) is a bone-metabolic disorder, causing micro-architecture degeneration and a decrease in bone density. Nutritional deficiency, i.e., calcium, vitamin D, and hormonal imbalances are the primary cause for the occurrence of OP. Although conventional diagnostic techniques and therapies are available and found to be effective only at a later stage, though still lack prevention strateg…
  • Opportunistic screening for low bone density using abdominopelvic computed tomography scans. [Journal Article]
    Med Phys. 2023 Feb 07 [Online ahead of print]Tariq A, N Patel B, … Banerjee I
  • CONCLUSIONS: The fusion model, which combines two planes of CT images and electronic medical records data, outperformed individual models and provided a high, robust diagnostic performance for opportunistic screening of low bone density using contrast and non-contrast CT exams. This model could potentially improve bone health risk assessment with no additional cost. The model's handling of metal implants is an ongoing effort. This article is protected by copyright. All rights reserved.
  • Identification of a stem cell mediating osteoblast versus adipocyte lineage selection. [Preprint]
    Res Sq. 2023 Jan 26Greenblatt M, Debnath S, … Cohen P
  • Most skeletal fragility disorders are characterized by bone loss with a concurrent gain in marrow adipocytes 1-8. This suggests that a cell that forms adipocytes at the expense of osteoblasts is central to the pathogenesis of skeletal disorders. However, this cellular point of bifurcation between adipocyte and osteoblast differentiation pathways remains unknown. Here, we identify a new cell type …
  • Social Isolation Causes Cortical and Trabecular Bone Loss in Adult Male, but not Female, C57BL/6J Mice. [Preprint]
    bioRxiv. 2023 Jan 28Mountain RV, Langlais AL, … Motyl KJ
  • Social isolation is a potent form of psychosocial stress and is a growing public health concern, particularly among older adults. Even prior to the onset of the COVID-19 pandemic, which has significantly increased the prevalence of isolation and loneliness, researchers have been concerned about a rising "epidemic" of loneliness. Isolation is associated with an increased risk for many physical and…
  • Probiotics and Prebiotics: Any Role in Menopause-Related Diseases? [Review]
    Curr Nutr Rep. 2023 Feb 07 [Online ahead of print]Barrea L, Verde L, … Muscogiuri G
  • The aim of this review is to provide an overview of the menopause-related changes in microbiota and their role in the pathogenesis of menopause-related diseases. In addition, evidence on probiotic supplementation as a therapeutic strategy is discussed.
  • Research progress on the extraction technology and activity study of Epimedium polysaccharides. [Review]
    Carbohydr Polym. 2023 Apr 15; 306:120602.Ke L, Duan X, … Fan Y
  • More pharmacological effects of polysaccharides from traditional Chinese medicines have been discovered in recent years. Epimedium has been used for thousands of years as a traditional Chinese medicine in China. Water-soluble Epimedium polysaccharides is one of the main ingredients of Epimedium, which is one of the main active ingredients of Epimedium, mainly composed of mannose, rhamnose, galact…
  • FSHR activation through small molecule modulators: Mechanistic insights from MD simulations. [Journal Article]
    Comput Biol Med. 2023 Jan 24; 154:106588.Kumar C, Idicula-Thomas S
  • Follicle-stimulating hormone receptor (FSHR) is a glycoprotein hormone receptor that plays a vital role in reproduction, cancer progression and osteoporosis. Owing to its therapeutic importance, several small molecule modulators have been identified by researchers through high throughput studies that usually include virtual screening of chemical libraries followed by in vitro validation through r…
  • Symptomatic fractures in systemic sclerosis: A case-control study. [Journal Article]
    J Scleroderma Relat Disord. 2023 Feb; 8(1):79-84.Sampaio-Barros MM, Bortoluzzo AB, … Sampaio-Barros PD
  • This case-control study analyzed risk factors for symptomatic fractures in a group of 52 patients with systemic sclerosis compared with a group of 104 patients without fractures, matched for sex and age, who were attended at a single systemic sclerosis outpatient clinic from 2010 to 2020. Fractures affected predominantly vertebral (65.4%), rib (13.5%), and hip (7.7%) joints, while the mean age of…
  • Computed tomography predictors of adult spinal cord injury without radiographic abnormality. [Journal Article]
    J Neurosci Rural Pract. 2022 Oct-Dec; 13(4):658-662.Singla N, Nellikoppad HS, … Ahuja CK
  • CONCLUSIONS: Osteoporosis, osteophytes, canal stenosis and ligament calcification are the factors that predispose adults to SCIWORA. The final outcome seems to be poorer in cases of canal stenosis when compared with osteophytes and osteoporosis. NCCT findings can be used as an adjunct to MRI to predict clinical presentation, severity and recovery in adult SCIWORA.
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