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1,643 results
  • Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle. [Journal Article]
    Vet Immunol Immunopathol 2020; 221:110025O'Brien MB, McLoughlin RM, Meade KG
  • Capturing the phenotypic variation in immune responses holds enormous promise for the development of targeted treatments for disease as well as tailored vaccination schedules. However, accurate detection of true biological variation can be obscured by the lack of standardised immune assays. The TruCulture® whole blood stimulation system has now been extensively used to detect basal and induced im…
  • Oxathiapiprolin, a Novel Chemical Inducer Activates the Plant Disease Resistance. [Journal Article]
    Int J Mol Sci 2020; 21(4)Peng Q, Wang Z, … Xia Y
  • Oxathiapiprolin was developed as a specific plant pathogenic oomycete inhibitor, previously shown to have highly curative and protective activities against the pepper Phytophthora blight disease under field and greenhouse tests. Therefore, it was hypothesized that oxathiapiprolin might potentially activate the plant disease resistance against pathogen infections. This study investigated the poten…
  • HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer. [Journal Article]
    Infect Agent Cancer 2020; 15:6Liu X, Ma H, … Yu L
  • Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an innate immune receptor, the nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes the pathogen-associated molecular pattern (PAMP), subsequently initiating immune responses. NOD…
  • Toll-like receptor 4: A promising crossroads in the diagnosis and treatment of several pathologies. [Review]
    Eur J Pharmacol 2020; 874:172975Garcia MM, Goicoechea C, … Pascual D
  • Toll-like receptor 4 (TLR4) is expressed in a wide variety of cells and is the central component of the mammalian innate immune system. Since its discovery in 1997, TLR4 has been assigned an ever-increasing number of functions that extend from pathogen recognition to tissue damage identification and promotion of the intrinsic "damage repair response" in pain, intestinal, respiratory and vascular …
  • The Lamin-Like LITTLE NUCLEI 1 (LINC1) Regulates Pattern-Triggered Immunity and Jasmonic Acid Signaling. [Journal Article]
    Front Plant Sci 2019; 10:1639Jarad M, Mariappan K, … Hirt H
  • Pathogen-associated molecular pattern (PAMP) recognition occurs by plasma membrane located receptors that induce among other processes nuclear gene expression. However, signaling to the nuclear compartment is restricted by the nuclear envelope and nuclear pore complexes. We show here that among the four Arabidopsis lamin homologs LITTLE NUCLEI/CROWDED NUCLEI (LINC/CRWN), LINC1 plays an important …
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