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(Paget Sir James)
60 results
  • Extramammary Paget disease. [Review]
    Dermatol Online J. 2019 Apr 15; 25(4)St Claire K, Hoover A, … Khachemoune A
  • In 1874, Sir James Paget first described Paget disease of the nipple, also known as mammary Paget disease. In 1889, extramammary Paget disease (EMPD) of the scrotum and penis was identified. Although mammary and extramammary Paget disease are both characterized by epidermal Paget cells and share a similar clinical presentation, their uniqueness lies in anatomical location and histogenesis. EMPD p…
  • Paget's Diseases: United by Epidermis and Epigenetics. [Journal Article]
    J Invest Dermatol. 2019 Apr; 139(4):753-754.Capell BC
  • Almost 150 years have passed since Sir James Paget described the disease that bears his name, but the molecular etiology and cellular origins of Paget's disease remain poorly understood. Herein, Zhang et al. (2018) bring Paget's disease into the genomics era, providing evidence for an epidermal origin for Paget's disease, as well as a high incidence of mutations in genes encoding epigenetic regul…
  • StatPearls: Trichinosis [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Furhad Shabi S Mclaren Oakland Bokhari Abdullah A. AA McLaren Oakland Hosp - Michigan State Un BOOK
  • Trichinosis or trichinellosis is a helminth infection primarily contracted from poor or improper preparation of food. Pork and its products are the primary sources of infection.[1] It can be potentially fatal, but more commonly is a self-limiting disease.[2] Discovery of trichinosis is attributed to Sir Richard Owen and Sir James Paget who in 1835, observed a mass of worms lining the diaphragm of…
  • StatPearls: Paget Schroetter Syndrome (Paget Von Schrotter Disease) [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Saleem Taimur T St. Dominic Hospital Baril Donald T. DT David Geffen School of Medicine UCLA BOOK
  • Paget Schroetter syndrome (PSS) is effort-induced thrombosis of the axillary and subclavian veins associated with compression of the subclavian vein at the thoracic outlet. It is the venous variant of thoracic outlet syndrome (TOS), the syndrome of symptoms associated with compression of the subclavian vein, subclavian artery or brachial plexus as they pass through the thoracic outlet. The descri…
  • Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era. [Historical Article]
    J Med Biogr. 2016 Nov; 24(4):500-506.Wessels Q, Correia JC, Taylor AM
  • Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that d…
  • Paget's disease with craniofacial and skeletal bone involvement. [Case Reports]
    BMJ Case Rep. 2016 Sep 01; 2016Rai NP, Anekar J, … Devang Divakar D
  • Paget's disease is a metabolic disorder of bone caused due to defect in the remodelling process and is very common in western countries but is very rare in Asians and Africans. It was first described by a British scientist Sir James Paget in 1877. It can be monostotic or polyostotic depending on the number of bones involved. It most commonly affects older people of more than 50 years. Disease inv…
  • Endotext: Paget’s Disease of Bone [BOOK]
    . MDText.com, Inc.: South Dartmouth (MA)Feingold KR, Anawalt B, … Wilson DPSinger FRBOOK
  • Sir James Paget described a skeletal disorder affecting one or more areas of the skeleton in 1876. It is most common in England and in countries to which the English migrated. In recent years the prevalence in most countries has decreased. A common feature is skeletal deformity which evolves over many years and is most visible in the skull and lower extremities. Pathological fractures are most li…
  • Mammary and extramammary Paget's disease. [Review]
    An Bras Dermatol. 2015 Mar-Apr; 90(2):225-31.Lopes Filho LL, Lopes IM, … Matsunaga N
  • Paget's disease, described by Sir James Paget in 1874, is classified as mammary and extramammary. The mammary type is rare and often associated with intraductal cancer (93-100% of cases). It is more prevalent in postmenopausal women and it appears as an eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration and inversion of the nipple. It must be distinguish…
  • The Paget Bicentenary: An Australian perspective. [Historical Article]
    J Med Biogr. 2018 Aug; 26(3):164-171.Toodayan N
  • The year 2014 marks the bicentenary of the birth of Sir James Paget (1814-1899), the celebrated English surgeon and pathologist. Although best known for his work on bone and breast disease, Paget also played an important role in the institution of Australia's first medical school. In this article, that involvement and Paget's other antipodean influences are summarised. The naming of Paget's disea…
  • Truncated ambition: Thomas King Chambers, MD (1817-1889). [Historical Article]
    J Med Biogr. 2016 May; 24(2):206-15.Drain S
  • Thomas King Chambers clearly intended to be a physician of note and at times indeed he was mentioned in the same breath as Sir James Paget (1814-1899), Sir Henry Acland (1815-1900) and Francis Anstie (1833-1874). At the time of his death his career was pronounced 'less than brilliant though far from inglorious'. He had made all the right political moves-networking through the medical societies, m…
  • Osteosarcoma in Paget's disease of bone. [Review]
    J Bone Miner Res. 2006 Dec; 21 Suppl 2:P58-63.Hansen MF, Seton M, Merchant A
  • Paget's disease of bone (PDB) is a focal disorder of bone metabolism first described by Sir James Paget in 1876. It is presumed benign in nature and mediated by abnormal osteoclast function. The incidence of osteosarcomas complicating PDB is estimated at <1%. These cancers occur mostly in persons with long-standing, polyostotic disease and affect patients in their seventh decade or when osteosarc…
  • A brief history of the pathology of the gonads. [Historical Article]
    Mod Pathol. 2005 Feb; 18 Suppl 2:S3-S17.Young RH
  • Our understanding of gonadal pathology has reached its current state as a result of the contributions of numerous outstanding investigators. Knowledge of testicular tumor pathology dates back to the great British workers Percival Pott and Sir Astley Cooper but the single greatest early stride was made with the description in 1906 by the French urologist Maurice Chevassu of the seminoma. The semin…
  • [Bone Paget's disease in the young adult]. [Case Reports]
    Rev Clin Esp. 2004 Oct; 204(10):532-4.Manero Ruiz FJ, Urruticoechea Arana A, … Pecondón Español A
  • CONCLUSIONS: In a young adult with high phosphatase alkaline values we will include BPD in the differential diagnosis.
  • Paget disease of bone. Diagnosis and indications for treatment. [Case Reports]
    Aust Fam Physician. 2004 Mar; 33(3):127-31.Kotowicz MA
  • CONCLUSIONS: Paget disease is associated with musculoskeletal pain, significant disability and impaired quality of life. Complications include pathological fracture, arthritis in adjacent joints, hearing loss, other neurological complications, heart failure and, rarely, osteosarcoma. Recent clinical trial data has demonstrated histological and radiological improvements in bone of patients treated with bisphosphonates. There is little data evaluating the long term effect of therapy on the risk of complications, however, restoration of normal bony architecture offers the prospect that complications related to deformity and increased bone fragility might be reduced by effective therapy.
  • Perianal extramammary Paget's disease. [Case Reports]
    Eur J Surg Oncol. 2000 Sep; 26(6):612-4.Jabbar AS
  • Perianal extramammary Paget's disease is a rare disorder of unknown aetiology and is frequently associated with malignancy. Since Sir James Paget's original description, extramammary Paget's disease has been surrounded by controversy, speculation and much interest on the part of surgeons, pathologists and dermatologists. This case report draws attention to this rare condition, which should be con…
  • Hutchinson and Nettleship, Nettlerash and albinism. [Historical Article]
    Br J Dermatol. 2000 Jul; 143(1):16-22.Branford WA
  • With specialization still in its infancy, Victorian surgeons were often concerned with the diagnosis and care of skin disorders. The careers of three London surgeons from successive generations, Sir James Paget, Sir Jonathan Hutchinson and Edward Nettleship are discussed with emphasis on their mutual influence and contributions to dermatology. Nettleship's original description of urticaria pigmen…
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