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Unbound Medicine.
(Paneth cells)
1,899 results
  • Identification, tissue characterization, and innate immune role of Angiogenin-4 expression in young broiler chickens. [Journal Article]
    Poult Sci. 2020 Jun; 99(6):2992-3000.Losada-Medina D, Yitbarek A, … Rodriguez-Lecompte JC
  • Intestinal epithelial cells are major producers of antimicrobial proteins, which play an important role in innate immunity. In addition to defensins, the Ribonuclease A superfamily includes important antimicrobial proteins involved in host-defense mechanisms in vertebrates. Angiogenin-4 (Ang4), a member of this RNase superfamily, has been demonstrated to be secreted by Paneth cells in mice. We ha…
  • LGR5 controls extracellular matrix production by stem cells in the developing intestine. [Journal Article]
    EMBO Rep. 2020 May 28 [Online ahead of print]Fernandez Vallone V, Leprovots M, … Garcia MI
  • The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling. In this study, phenotype analysis of knockin/knockout Lgr5-eGFP-IRES-Cre and Lgr5-DTReGFP embryos reveals that Lgr5 deficiency during Wnt-mediated cytodifferentiation results in amplification of ISCs and early differentiation into Paneth cells, which can be counteracted by in utero treatment with…
  • IDO1+ Paneth cells promote immune escape of colorectal cancer. [Journal Article]
    Commun Biol. 2020 May 22; 3(1):252.Pflügler S, Svinka J, … Eferl R
  • Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to revert immunosuppression. However, the underlying mechanisms of immune escape are still poorly understood. Here we discover Indoleamine-2,3-dioxygen…
  • Extracellular Vesicles with Possible Roles in Gut Intestinal Tract Homeostasis and IBD. [Review]
    Mediators Inflamm. 2020; 2020:1945832.Chang X, Wang SL, … Bai Y
  • The intestinal tract consists of various types of cells, such as epithelial cells, Paneth cells, macrophages, and lymphocytes, which constitute the intestinal immune system and play a significant role in maintaining intestinal homeostasis by producing antimicrobial materials and controlling the host-commensal balance. Various studies have found that the dysfunction of intestinal homeostasis contr…
  • Inflammatory Bowel Diseases: Host-Microbial-Environmental Interactions in Dysbiosis. [Review]
    Diseases. 2020 May 10; 8(2)Colquhoun C, Duncan M, Grant G
  • Crohn's Disease (CD) and Ulcerative Colitis (UC) are world-wide health problems in which intestinal dysbiosis or adverse functional changes in the microbiome are causative or exacerbating factors. The reduced abundance and diversity of the microbiome may be a result of a lack of exposure to vital commensal microbes or overexposure to competitive pathobionts during early life. Alternatively, many …
  • Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro. [Journal Article]
    Front Microbiol. 2020; 11:821.Luo H, Zheng J, … Li X
  • Porcine deltacoronavirus (PDCoV) is a novel emerging enteric coronavirus found in pigs. Intestinal enteroids, which partially recreate the structure and function of intestinal villi-crypts, have many physiological similarities to the intestinal tissues in vivo. Enteroids exhibit advantages in studying the interactions between intestines and enteric pathogens. To create a novel infection model for…
  • Salmonella Enteritidis Effector AvrA Suppresses Autophagy by Reducing Beclin-1 Protein. [Journal Article]
    Front Immunol. 2020; 11:686.Jiao Y, Zhang YG, … Sun J
  • Autophagy is a cellular process to clear pathogens. Salmonella enterica serovar Enteritidis (S.E) has emerged as one of the most important food-borne pathogens. However, major studies still focus on Salmonella enterica serovar Typhimurium. Here, we reported that AvrA, a S. Enteritidis effector, inhibited autophagy to promote bacterial survival in the host. We found that AvrA regulates the convers…
  • An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease. [Review]
    Front Immunol. 2020; 11:646.Wehkamp J, Stange EF
  • The Paneth cells reside in the small intestine at the bottom of the crypts of Lieberkühn, intermingled with stem cells, and provide a niche for their neighbors by secreting growth and Wnt-factors as well as different antimicrobial peptides including defensins, lysozyme and others. The most abundant are the human Paneth cell α-defensin 5 and 6 that keep the crypt sterile and control the local micr…
  • Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice. [Journal Article]
    Life Sci Alliance. 2020 Jun; 3(6)Shimizu Y, Nakamura K, … Ayabe T
  • Crohn's disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of ER homeostasis in Paneth cells of the small intestine, and α-defensin misfolding have been reported in CD patients. Because α-defensins regulate the composition of the intestinal microbiota, their misfolding may …
  • Interleukin-4 suppresses the proliferation and alters the gene expression in enteroids. [Journal Article]
    Cytotechnology. 2020 Jun; 72(3):479-488.Saito Y, Iwatsuki K, … Kobayashi-Hattori K
  • Interleukin (IL)-4 is known as a cytokine mainly involved in allergy and inflammation, but recent studies have suggested that IL-4 plays a part in the differentiation process of various cells. Since the effect of IL-4 on intestinal epithelial cells, particularly cryptic cells including stem cells, is poorly understood, we investigated IL-4-induced changes in intestinal epithelial cells using mous…
  • The Paneth Cell: The Curator and Defender of the Immature Small Intestine. [Review]
    Front Immunol. 2020; 11:587.Lueschow SR, McElroy SJ
  • Paneth cells were first described in the late 19th century by Gustav Schwalbe and Josef Paneth as columnar epithelial cells possessing prominent eosinophilic granules in their cytoplasm. Decades later there is continued interest in Paneth cells as they play an integral role in maintaining intestinal homeostasis and modulating the physiology of the small intestine and its associated microbial flor…
  • Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation. [Review]
    Front Physiol. 2020; 11:280.Singh R, Balasubramanian I, … Gao N
  • Paneth cells are residents of the intestinal epithelium. Abnormal appearance of Paneth cells has been widely documented in non-intestinal tissues within the digestive tract and even observed in non-gastrointestinal organs. Although metaplastic Paneth cells are part of the overarching pathology of intestinal metaplasia (IM), only a fraction of intestinal metaplastic lesions contain Paneth cells. W…
  • The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome. [Journal Article]
    Microorganisms. 2020 Apr 14; 8(4)Oliveira MC, Coutinho LB, … Silva NM
  • Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range of biological processes such as biodegradation and biosynthesis, as well as immune function, fetal development, and physical and mental well-being. This work aimed to investigate the effect of iron deprivation in Toxoplasma gondii in…
  • Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy. [Review]
    World J Stem Cells. 2020 Mar 26; 12(3):188-202.Gao YL, Shao LH, … Chang PY
  • In steady state, the intestinal epithelium forms an important part of the gut barrier to defend against luminal bacterial attack. However, the intestinal epithelium is compromised by ionizing irradiation due to its inherent self-renewing capacity. In this process, small intestinal bacterial overgrowth is a critical event that reciprocally alters the immune milieu. In other words, intestinal bacte…
  • Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium. [Journal Article]
    Lab Anim Res. 2019; 35:26.Seo Y, Oh SJ, … Kim HS
  • Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, has been spotlighted as a potential cause for the promotion and acceleration of periodontitis-associated systemic disorders. To investigate the association between Pg and intestinal disease…
  • Generation of an enteric smooth muscle cell line from the pig ileum. [Journal Article]
    J Anim Sci. 2020 Apr 01; 98(4)Ji X, Lyu P, … Jiang H
  • Smooth muscle cells (SMCs) play an important role in physiology and production in farm animals such as pigs. Here, we report the generation of a pig SMC line. Our original objective was to establish an enteroendocrine cell line from the pig ileum epithelium through lentiviral transduction of the Simian Virus (SV) 40 large T antigen. However, an initial expression analysis of marker genes in nine …
  • Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. [Journal Article]
    PLoS One. 2020; 15(4):e0230231.Pearce SC, Weber GJ, … Breault DT
  • Enteroids are cultured primary intestinal epithelial cells that recapitulate epithelial lineage development allowing for a more complex and physiologically relevant model for scientific study. The large presence of intestinal stem cells (ISC) in these enteroids allows for the study of metabolite effects on cellular processes and resulting progeny cells. Short-chain fatty acids (SCFA) such as buty…
  • Astaxanthin (ATX) enhances the intestinal mucosal functions in immunodeficient mice. [Journal Article]
    Food Funct. 2020 Apr 01; 11(4):3371-3381.Zhang L, Cao W, … Tang Q
  • Increasing pressure of life may bring some disease risks and stress injuries, which may destroy the immune system and result in intestinal mucosal immune disorders. In this study, the effects of different doses of ATX (30 mg per kg b.w., 60 mg per kg b.w. and 120 mg per kg b.w.) on intestinal mucosal functions were explored in cyclophosphamide (Cy)-induced immunodeficient mice. The results showed…
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