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(Paneth cells)
1,820 results
  • Use of l-pNIPAM hydrogel as a 3D-scaffold for intestinal crypts and stem cell tissue engineering. [Journal Article]
    Biomater Sci 2019Dosh RH, Jordan-Mahy N, … Le Maitre CL
  • Intestinal stem cells hold great potential in tissue regeneration of the intestine, however, there are key limitations in their culture in vitro. We previously reported a novel synthetic non-biodegradable hydrogel as a 3D culture model for intestinal epithelium using Caco2 and HT29-MTX cells. Here, we investigated the potential of this system as a 3D scaffold for crypts and single intestinal stem…
  • Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers. [Journal Article]
    J Vis Exp 2019; (149)Fasciano AC, Blutt SE, … Mecsas J
  • M (microfold) cells of the intestine function to transport antigen from the apical lumen to the underlying Peyer's patches and lamina propria where immune cells reside and therefore contribute to mucosal immunity in the intestine. A complete understanding of how M cells differentiate in the intestine as well as the molecular mechanisms of antigen uptake by M cells is lacking. This is because M ce…
  • Roads to the Fountain of youth?: Rejuvenating intestinal stem cells. [Journal Article]
    Rejuvenation Res 2019Larrick J, Mendelsohn AR
  • The intestinal stem cells (ISC) of old mice and humans exhibit a reduced capacity for regeneration and repair. Compromised intestinal function may play a key role in systemic aging-related changes: not only in the affected gut, but also in the nervous and cardiovascular systems. For example, progression of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's has been linked …
  • Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor. [Journal Article]
    FASEB J 2019; :fj201900727RLu R, Zhang YG, … Sun J
  • Apoptosis and autophagy are dynamic processes that determine the fate of cells. Vitamin D receptor (VDR) deficiency in the intestine leads to abnormal Paneth cells and impaired autophagy function. Here, we will elucidate the mechanisms of the intestinal epithelial VDR regulation of autophagy and apoptosis. We used in vivo VDRlox and VDR∆IEC mice and ex vivo organoids generated from small intestin…
  • Regulation of Small Intestinal Epithelial Homeostasis by Tsc2-mTORC1 Signaling. [Journal Article]
    Kobe J Med Sci 2019; 64(6):E200-E209Setiawan J, Kotani T, … Matozaki T
  • Mammalian target of rapamycin complex 1 (mTORC1), a protein complex containing the serine/threonine kinase mTOR, integrates various growth stimulating signals. mTORC1 is expressed in intestinal epithelial cells (IECs), whereas the physiological roles of this protein complex in homeostasis of IECs remain virtually unknown. We here generated mice, in which tuberous sclerosis complex 2 (Tsc2), a neg…
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