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1,998 results
  • A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp. [Journal Article]
    PLoS Negl Trop Dis 2019; 13(10):e0007742Albuquerque P, Nicola AM, … Silva-Pereira I
  • Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete their life cycle. Despite this, they developed sophisticated virulence attributes allowing them not only to survive in host tissues but also to c…
  • Decyl gallate as a possible inhibitor of N-glycosylation process in Paracoccidioides lutzii. [Journal Article]
    Antimicrob Agents Chemother 2019de Paula E Silva ACA, de Oliveira HC, … Mendes-Giannini MJS
  • The available antifungal therapeutic arsenal is limited. The search for alternative drugs with fewer side effects and new targets remains a major challenge. Decyl gallate (G14) is a derivative of gallic acid with a range of biological activities and wide spectra antifungal activity. Previously, our group demonstrated the promising anti-Paracoccidioides activity of G14. In this work, aiming to eva…
  • Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis. [Journal Article]
    PLoS Pathog 2019; 15(8):e1007990Ketelut-Carneiro N, Souza COS, … Silva JS
  • The granulomatous lesion resulting from infection with the fungus Paracoccidioides brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a fibroblast- and collagen-rich content. Granuloma formation requires signaling elicited by inflammatory molecules such as members of the interleukin-1 family. Two members of this family have been thoroughly studied, namely IL-1α an…
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