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(Parkinson’s Disease)
108,081 results
  • Chrysoeriol mediates mitochondrial protection via PI3K/Akt pathway in MPP+ treated SH-SY5Y cells. [Journal Article]
    Neurosci Lett 2019; :134545Limboonreung T, Tuchinda P, Chongthammakun S
  • Chrysoeriol is a plant flavone extracted from the roots and leaves of the genus Phyllanthus. Although many biological properties of chrysoeriol have been reported, such as its antioxidant and anti-inflammatory activities, the effects of chrysoeriol on the cellular models of Parkinson's disease (PD) have not yet been elucidated. In the present study, we aimed to investigate whether chrysoeriol pre…
  • Drug Choices and Advancements for Managing Depression in Parkinson`s Disease. [Journal Article]
    Curr Neuropharmacol 2019Assogna F, Pellicano C, … Pontieri FE
  • Depression is a frequent non-motor symptom of Parkinson's disease (PD), and may even precede the onset of motor symptoms of parkinsonism. Beyond its negative influence on mood and affection, depression in PD is frequently associated with other neuropsychiatric symptoms and with late- stage complications such as dementia. Despite its profound impact on quality of life and cognitive functioning in …
  • Cell therapy for central nervous system disorders: Current obstacles to progress. [Review]
    CNS Neurosci Ther 2019Yasuhara T, Kawauchi S, … Date I
  • Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various clinical studies are underway for Parkinson's disease, stroke, traumatic brain injury, and various other neurological diseases. Recent biotechnological developments in cell therapy have taken advantage of the technology of induced pluripotent stem (iPS) cells. The advent of iPS …
  • Submentalis REM Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy. [Journal Article]
    Ann Neurol 2019McCarter SJ, Feemster JC, … St Louis EK
  • Accurate antemortem diagnosis of Parkinsonism is primarily based on clinical evaluation with limited biomarkers. We evaluated the diagnostic utility of quantitative REM sleep without atonia analysis in the submentalis and anterior tibialis muscles in parkinsonian patients (53 synucleinopathy, 24 tauopathy). Receiver-operating characteristic curves determined REM sleep without atonia cutoffs disti…
  • Feasibility of repeat and bilateral submandibular gland needle biopsies in Parkinson's disease. [Journal Article]
    Parkinsonism Relat Disord 2019; 68:69-72Adler CH, Serrano GE, … Beach TG
  • CONCLUSIONS: This is the first published study of bilateral transcutaneous needle biopsies of the SMG in living patients with PD which showed better tissue acquisition and a change in aSyn density over time. While further study is needed, there is potential for SMG biopsies to serve as a tissue biomarker for PD disease progression and potentially as a peripheral outcome measure for anti-aSyn treatment.
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