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76,704 results
  • Subcortical Effects on Voice and Fluency in Dysarthria: Observations from Subthalamic Nucleus Stimulation. [Journal Article]
  • JAJ Alzheimers Dis Parkinsonism 2017; 7(6)
  • Sidtis D, Sidtis JJ
  • CONCLUSIONS: Deep brain stimulation disrupts fluency and improves voice in spontaneous speech, reflecting an inverse influence of subcortical systems on articulatory posturing and laryngeal mechanisms. Better voice and less dysfluency in repetition may occur because an external model reduces the speech planning burden, as seen for gait and arm reach. These orthogonal results for fluency versus phonatory competence may account for ambivalent reports from dysarthric speakers and reveal the complexity of subcortical control of motor speech.
  • Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. [Journal Article]
  • PRParkinsonism Relat Disord 2018 Feb 12
  • Schwiertz A, Spiegel J, … Unger MM
  • CONCLUSIONS: Fecal markers reflecting intestinal inflammation and increased intestinal permeability have been primarily investigated in inflammatory bowel disease so far. Our data indicate that calprotectin, alpha-1-antitrypsin and zonulin could be useful non-invasive markers in PD as well. Even though these markers are not disease-specific, they corroborate the hypothesis of an intestinal inflammation as contributing factor in the pathogenesis of PD. Further investigations are needed to determine whether calprotectin, alpha-1-antitrypsin and zonulin can be used to define PD subgroups and to monitor the effect of interventions in PD.
  • Historical perspectives on tardive dyskinesia. [Review]
  • JNJ Neurol Sci 2018 Feb 03
  • Caroff SN, Ungvari GS, Cunningham Owens DG
  • Tardive dyskinesia (TD) is a persistent hyperkinetic movement disorder associated with dopamine receptor blocking agents including antipsychotic medications. Although uncertainty and concern about th...
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