- Epithelioid Hemangioendothelioma of the Bowel in Crohn's Disease: The First Reported Case. [Journal Article]
- IJInt J Surg Pathol 2018 Sep 21; :1066896918801527
- CONCLUSIONS: Long-standing inflammatory bowel disease is associated with significant risk for developing neoplasms, usually carcinomas, which can be indistinguishable radiologically and clinically from nonneoplastic complications. These tumors are often identified as an incidental finding in specimens resected for clinically severe disease. This is the first report of EHE arising in the bowel affected by CD, and it mimicked mural fibrosis and fissures.
- Retrospective Clinical and Microbiologic Analysis of Patients with Anorectal Abscess. [Journal Article]
- SISurg Infect (Larchmt) 2018 Sep 20
- CONCLUSIONS: Escherichia coli is the most common micro-organism cultured from patients presenting with anorectal abscess. Despite an increase in community-acquired multi-resistant strains, our results show a low overall incidence of such isolate. Our study provides a large microbiologic sample of patients with anorectal abscess to expand the present knowledge of the etiology of a common surgical condition.
- The role of multimodal treatment in Crohn's disease patients with perianal fistula: a multicentre retrospective cohort study. [Journal Article]
- APAliment Pharmacol Ther 2018 Sep 18
- CONCLUSIONS: Multimodality treatment, anti-TNFs use, and removal of setons after multimodality treatment can result in improved outcomes in CD patients with perianal fistulae and reduce the need for repeat surgery and radical surgery.
- Human Amniotic Membrane Effect on Perianal Fistula Healing in Rabbits: An Experimental Study. [Journal Article]
- IJIran J Med Sci 2018; 43(5):473-478
- CONCLUSIONS: HAM has an effective role in enhancing the ERF procedure and considered appropriate. A combination of HAM with other methods is recommended.
- Canine Perianal Fistulas: Clinical Presentation, Pathogenesis, and Management. [Review]
- VCVet Clin North Am Small Anim Pract 2018 Sep 11
- Canine perianal fistulas are painful sinus tracts and ulcers that spontaneously develop in the skin around the anus. Middle-aged German shepherd dogs are most commonly affected and may have a genetic...
Canine perianal fistulas are painful sinus tracts and ulcers that spontaneously develop in the skin around the anus. Middle-aged German shepherd dogs are most commonly affected and may have a genetic susceptibility. Although the disease was once believed related to conformational factors and primarily managed surgically, an immune-mediated pathogenesis is now recognized. Long-term medical management with immunomodulatory agents has become standard of care for canine perianal fistulas. Perianal fistulas can be debilitating and have a negative impact on quality of life of dogs and owners. Accurate diagnosis and aggressive medical therapy are key to successful management of canine perianal fistulas.
- Can Perianal Fistula Be Treated Non-surgically with Platelet-Rich Fibrin Sealant? [Journal Article]
- JGJ Gastrointest Surg 2018 Sep 05
- CONCLUSIONS: Outpatient treatment of perianal fistula is totally innocuous. It is a very low cost procedure and the results obtained are highly acceptable (similar to those of the surgical insertion of a plug, with traditional curettage). Therefore, we believe this approach should be considered a valid initial treatment for perianal fistula, reserving surgical treatment (curettage and sealing using a cylindrical-curette kit) for cases in which this initial method is unsuccessful. This would avoid many complications and achieve considerable financial savings for the health system.
- Adenocarcinoma Arising from Perianal Fistulizing Crohn's Disease. [Journal Article]
- CRCase Rep Gastroenterol 2018 May-Aug; 12(2):390-395
- Perianal fistula is a very debilitating event and a cause of morbidity in patients with Crohn's disease (CD). Its malignant transformation is very rare with an incidence of around 0.004-0.7$. Presenc...
Perianal fistula is a very debilitating event and a cause of morbidity in patients with Crohn's disease (CD). Its malignant transformation is very rare with an incidence of around 0.004-0.7$. Presence of disease in the colon and rectum is the major risk factor for the development of a perianal fistula. In this report we show a case of adenocarcinoma arising from a perianal fistulizing CD. This type of tumor is highly aggressive, difficult to diagnose, and has a rather poor prognosis. The different neoplastic transformations and the different types of tumors that may appear in patients with CD, especially at the colorectal level or at the level of an eventual anastomosis, are to date well documented and described in the literature, while there is a lack of information and of treated cases concerning the occurrence of cancer at the level of a fistula. Due to the rarity of cases, we tried to identify the most frequent and important risk factors: sex, duration of disease, age at diagnosis, and the history of the fistula.
- Constipation, failure to thrive and recurrent abscesses: getting to the bottom of an unusual complaint. [Journal Article]
- ADArch Dis Child Educ Pract Ed 2018 Sep 03
- QUESTION 1: Which procedure may have been most appropriate to offer an initial clue to her diagnosis? Abdominal X-ray. Digital rectal examination. Perianal swab for streptococcal infection. Sweat tes...
QUESTION 1: Which procedure may have been most appropriate to offer an initial clue to her diagnosis? Abdominal X-ray. Digital rectal examination. Perianal swab for streptococcal infection. Sweat test. Ultrasound scan of the abdomen. At 6 months of age, she presented with a second abscess, constipation and poor weight gain. QUESTION 2: What is the most likely diagnosis? Congenital anorectal anomaly. Cow's milk protein allergy. Hirschsprung's disease. Immunodeficiency disorder. Infantile perianal Crohn's disease. Poor weight gain persisted and she re-presented acutely unwell at 9 months of age with a ruptured perianal abscess. Given these recurrent abscesses, with associated failure to thrive and constipation, further investigations were arranged. MRI scan of the abdomen, pelvis and spine (figure 1) identified a heterogeneous presacral mass with fusion of the distal sacral segments.edpract;archdischild-2018-315317v1/F1F1F1Figure 1Sagittal T2-weighted MRI showing presacral mass, which measured approximately 20×20×19 mm. QUESTION 3: The combination of congenital anorectal stenosis, anterior sacral defect and a presacral mass is also known as: CHARGE syndrome.Currarino syndrome. Klippel-Feil syndrome. Opitz syndrome. VACTERL (vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities) association. Answers can be found on page 2.
- Significant medical and surgical morbidity in perianal Crohn's disease: Results from a territory-wide study. [Journal Article]
- JCJ Crohns Colitis 2018 Aug 25
- CONCLUSIONS: Over 40% CD patients presented with perianal disease at diagnosis. Chinese patients with PCD had poor outcomes, with young age of onset, multiple antibiotic use and repeated surgery.
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- Contrast- vs. non-contrast enhanced MR data sets for characterization of perianal fistulas. [Journal Article]
- ARAbdom Radiol (NY) 2018 Aug 29
- CONCLUSIONS: Although contrast-enhanced MR studies can improve a radiologist's confidence, non-contrast MR studies had similar diagnostic efficacy in identifying perianal fistulas and their complications. Therefore, a non-contrast study may suffice in selected patients such as those with renal impairment.