- High-Resolution Nerve Ultrasound and Electrophysiological Findings in Restless Legs Syndrome. [Journal Article]
- JNJ Neuroimaging 2018 May 11
- CONCLUSIONS: Early diagnosis, characterization, and treatment of neuropathy are increasingly relevant for RLS patients as it correlates with disease severity. HRUS revealed a pattern resembling diabetic neuropathy, which implies a similar pathophysiology with metabolic and ischemic origin of RLS-related axonal neuropathy.
- Cauda equina syndrome following an uneventful spinal anesthesia in a patient undergoing drainage of the Bartholin abscess: A case report. [Case Reports]
- MMedicine (Baltimore) 2018; 97(19):e0693
- Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots o...
Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage.
- Vitamin B6 in Health Supplements and Neuropathy: Case Series Assessment of Spontaneously Reported Cases. [Journal Article]
- DSDrug Saf 2018 May 08
- CONCLUSIONS: Causality assessment of the case series of 90 reports to Lareb shows it is plausible for the vitamin B6 supplements to have caused complaints such as neuropathies. This is especially the case with higher dosages and prolonged use, but dosages < 50 mg/day also cannot be excluded.
- Assessing sudomotor impairment in patients with peripheral neuropathy: Comparison between electrochemical skin conductance and skin biopsy. [Journal Article]
- CNClin Neurophysiol 2018 Apr 27; 129(7):1341-1348
- CONCLUSIONS: ESC measurement is a novel method of potential value for assessing sudomotor function. More studies are required to define its place beside ancient well-established techniques.The weak correlation of ESC with skin biopsy results suggests that mechanisms other than the loss of innervating fibres may be responsible for sweat gland dysfunction in polyneuropathies.
- Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study. [Journal Article]
- JPJ Peripher Nerv Syst 2018 Apr 23
- Chronic polyneuropathy is a disabling condition of the peripheral nerves, characterized by symmetrical sensory motor symptoms and signs. There is paucity of studies on the etiological spectrum of pol...
Chronic polyneuropathy is a disabling condition of the peripheral nerves, characterized by symmetrical sensory motor symptoms and signs. There is paucity of studies on the etiological spectrum of polyneuropathy and its impact on quality of life (QoL). The present cross-sectional study in a referral based tertiary care center in North India found diabetic neuropathy as the commonest cause (25.5%) amongst 212 patients with chronic polyneuropathy. Idiopathic axonal polyneuropathy was present in 14.2% patients. Leprosy presenting as confluent mononeuritis multiplex constituted 11.3% of the patients. Additionally, it revealed a significantly worse QoL in these patients in all domains measured by short form (SF-36). This is the first study conducted in India to determine the QoL in chronic neuropathy patients. The current study demonstrates the clinical feasibility and applicability of the SF-36 generic health status in patients with polyneuropathies.
- Behavioural, morphological and electrophysiological assessment of the effects of type 2 diabetes mellitus on large and small nerve fibres in Zucker diabetic fatty, Zucker lean and Wistar rats. [Journal Article]
- EJEur J Pain 2018 Apr 20
- CONCLUSIONS: ZDF rats presented a diabetic neuropathy involving large and small nerve fibres; additionally, ZL and WH rats also showed early small abnormalities in C-fibres, clearly detected by microneurography SIGNIFICANCE: This study provides a functional description of large and small nerve fibre function in a diabetic model that recapitulates many of the findings observed in patients suffering from type 2 diabetes mellitus.
- Compression neuropathy of common peroneal nerve caused by a popliteal cyst: A case report. [Case Reports]
- MMedicine (Baltimore) 2018; 97(16):e9922
- CONCLUSIONS: In this case, compression of the common peroneal nerve was due to an extraneural popliteal cyst, a situation rarely encountered. MRI can show in better detail their size and internal contents as well as their relation with surrounding anatomic structures. Patients with nerve entrapment caused by enlarged or ruptured cysts must be microsurgically excised if symptomatic.
- Overall Disability Sum Score for Clinical Assessment of Neurological Involvement in Eosinophilic Granulomatosis With Polyangiitis. [Journal Article]
- JCJ Clin Rheumatol 2018 Apr 13
- CONCLUSIONS: Overall Disability Sum Score could be a rapid, simple, reliable instrument to evaluate the severity of disability and nerve damage due to neurological involvement caused by vasculitis and to predict, at presentation, improvement and risk of neurological worsening.
- Paraneoplastic sensorimotor polyneuropathy in prostatic adenocarcinoma: A case report. [Case Reports]
- MMedicine (Baltimore) 2018; 97(15):e0030
- CONCLUSIONS: This case report is the first to report anti-Hu antibody-positive paraneoplastic sensorimotor neuropathy in a patient with adenocarcinoma of the prostate.
New Search Next
- [Immune Checkpoint Inhibitors and Neuromuscular Adverse Events]. [Journal Article]
- BNBrain Nerve 2018; 70(4):461-466
- Neuromuscular adverse events (AEs) in cancer patients treated with immune checkpoint inhibitors (ICIs) are characterized by diverse clinical subsets. The general features of neuromuscular AEs have re...
Neuromuscular adverse events (AEs) in cancer patients treated with immune checkpoint inhibitors (ICIs) are characterized by diverse clinical subsets. The general features of neuromuscular AEs have remained elusive due to its low frequency, ranging from 1-2% of cancer patients undergoing ICIs therapy. The diseases affect the central nervous system, peripheral nerves, neuromuscular junction, and muscle. Disease onset and progression may be rapid with a critical clinical course. The clinical presentation may differ from that of patients whose symptoms are unrelated to drugs. Headache, dizziness, and dysgeusia are relatively common and mild treatment-related AEs. In contrast, immune-related AEs, such as autoimmune encephalitis, demyelinating polyneuropathy, myasthenia, and myositis are more serious conditions. There is a strong correlation between ICIs and myasthenia, myositis, and myocarditis. Immune-modulating medication is generally effective for neuromuscular AEs. However, there are guidelines for treatment, and checkpoint inhibitor therapy should be withheld until the pathophysiology of the AEs is defined. Both CD8<sup>+</sup> cytotoxic T cells and autoantibodies are involved in the pathogenesis of neuromuscular AEs. Therefore, understanding the mechanisms of neuromuscular AEs is necessary to alleviate the symptoms associated with ICIs therapy in cancer patients.