- Community REACH: An Implementation of an Evidence-Based Caregiver Program. [Journal Article]
- GGerontologist 2018 Mar 19; 58(2):e130-e137
- Family caregivers (CGs) are critical to the provision of long-term services and support for older adults. Numerous intervention programs to alleviate CG distress have been developed and evaluated yet...
Family caregivers (CGs) are critical to the provision of long-term services and support for older adults. Numerous intervention programs to alleviate CG distress have been developed and evaluated yet few have been implemented in community settings. This paper describes and presents outcomes from Community REACH, a community implementation of the evidence-based Resources for Enhancing Alzheimer's Caregiver Health (REACH) II program.
- Deciding on cystic fibrosis carrier screening: three citizens' juries and an online survey. [Journal Article]
- EJEur J Public Health 2018 Mar 19
- CONCLUSIONS: Considering the favourable attitude towards CF screening, the feasibility of CF screening, in terms of best setting, target age and healthcare professionals providing it, should be tested in a clinical trial.
- A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. [Journal Article]
- ESEnviron Sci Process Impacts 2018 Mar 21
- Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposu...
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposure are needed for targeting interventions to protect children. Nitro-derivatives of PAH can act as markers of exposure to diesel exhaust, gasoline exhaust, or general combustion sources. Using a novel HPLC-APCI-MS/MS detection method, we examined four hemoglobin (Hb) adducts of nitro-PAH metabolites and the Hb adduct of a benzo[a]pyrene (BaP) metabolite in 22 umbilical cord blood samples. The samples were collected from a birth cohort with comprehensive data on prenatal PAH exposure, including prenatal personal air monitoring and DNA adducts in maternal and umbilical cord blood. Using non-parametric analyses, heat maps, and principal component analysis (PCA), we analyzed the relationship between the five Hb adducts and previous PAH measurements, with each measurement representing a different duration of exposure. We found that Hb adducts derived from several diesel-related nitro-PAHs (2-nitrofluorene and 1-nitropyrene) were significantly correlated (r = 0.77, p ≤ 0.0001) and grouped together in PCA. Nitro-PAH derived Hb adducts were largely unrelated to previously collected measures of exposure to a number of PAH parent compounds. These measures need to be validated in a larger sample.
- Safety and efficacy of maintenance ketamine treatment in patients with treatment-refractory generalised anxiety and social anxiety disorders. [Journal Article]
- JPJ Psychopharmacol 2018 Mar 01; :269881118762073
- CONCLUSIONS: Weekly ketamine dosing was safe and well tolerated, and post-dose dissociative symptoms tended to reduce after repeated dosing. Patients reported marked improvements in functionality and in their personal lives. Maintenance ketamine may be a therapeutic alternative for patients with treatment refractory GAD/SAD.
- Metabolite Biometrics for the Differentiation of Individuals. [Journal Article]
- ACAnal Chem 2018 Mar 21
- Sweat is a biological fluid present on the skin surface of every individual and is known to contain amino acids as well as other low molecular weight compounds. Each individual is inherently differen...
Sweat is a biological fluid present on the skin surface of every individual and is known to contain amino acids as well as other low molecular weight compounds. Each individual is inherently different from one another based on certain factors including, but not limited to, his/her genetic make-up, environment, and lifestyle. As such, the biochemical composition of each person greatly differs. The concentrations of the biochemical content within an individual's sweat are largely controlled by metabolic processes within the body that fluctuate regularly based on attributes such as age, gender, and activity levels. Therefore, the concentrations of these sweat components are person-specific and can be exploited, as presented here, to differentiate individuals based on trace amounts of sweat. For this concept, we analyzed three model compounds - lactate, urea, and glutamate. The average absorbance change from each compound in sweat was determined using three separate bioaffinity-based systems: lactate oxidase coupled with horseradish peroxidase (LOx-HRP), urease coupled with glutamate dehydrogenase (UR-GlDH), and glutamate dehydrogenase alone (GlDH). After optimizing a linear dependence for each assay to its respective analyte, analysis was performed on 50 mimicked sweat samples. Additionally, a collection and extraction method was developed and optimized by our group to evaluate authentic sweat samples from the skin surface of 25 individuals. A multivariate analysis of variance (MANOVA) test was performed to demonstrate that these three single-analyte enzymatic assays were effectively used to identify each person in both sample sets. This novel sweat analysis approach is capable of differentiating individuals based on the collective responses from the chosen metabolic compounds in sweat, without the use of DNA. Applications for this newly developed, non-invasive analysis can include the field of forensic science in order to differentiate between individuals, as well as the fields of homeland security and cybersecurity for personal authentication via unlocking mechanisms in smart devices that monitor metabolites. Through further development and analysis, this concept also has the potential to be clinically applicable in monitoring the health of individuals based on particular biomarker combinations.
- [Chapter 6. The law on the modernization of our health system: the provisions regarding health data]. [Journal Article]
- JIJ Int Bioethique Ethique Sci 2017 Oct 27; 28(3):57-61
- The Law on the Modernization of our Health System passed in 2016 exteds the scope of the medical secrecy by creating the patients' shared health record. All health professionnals involved in the care...
The Law on the Modernization of our Health System passed in 2016 exteds the scope of the medical secrecy by creating the patients' shared health record. All health professionnals involved in the care pathway have an access to all recorded information. The patient can access to it via a dedicated Internet website. The implementing decrees of this facility determine the modalities to share the information and frame the creation of this automated processing of personal data. At last, this law creates an open and secure access to helath data in the interest of collectivity. This open data in health is placed under the governance of the Health Data National Institute.
- [Chapter 1. From the study of risks to the translation of the ethical issues of Big Data in Health]. [Journal Article]
- JIJ Int Bioethique Ethique Sci 2017 Oct 27; 28(3):15-25
- Big Data substantially disrupt the medical microcosm up to challenge the paradigms of Medicine Hippocrates as we previously know. Therefore, a reflection on the study of risks associated with ethical...
Big Data substantially disrupt the medical microcosm up to challenge the paradigms of Medicine Hippocrates as we previously know. Therefore, a reflection on the study of risks associated with ethical issues around personal health data is imposed on us. Our study is based on many field surveys, interviews targeted at different actors, as well as a literature search on the subject. This work led to the realization of an innovative method of alignment of concepts of ontology of the risks to those of ontology of ethical objectives requirements of Big Data in Health. The aim is to make sense and recommendations to realization, implementation and use of personal data in order to better control it.
- Prioritization of the essentials in the spending patterns of Canadian households experiencing food insecurity. [Journal Article]
- PHPublic Health Nutr 2018 Mar 21; :1-14
- CONCLUSIONS: The spending patterns of food-insecure households suggest that they prioritized essential needs above all else.
- Impact of different recruitment strategies on accelerometry adherence and resulting physical activity data: A secondary analysis. [Journal Article]
- PMPrev Med Rep 2018; 10:76-81
- Strategies for increasing adherence to physical activity assessments are often linked to extra financial or personal effort. This paper aims to investigate the influence of the recruitment strategy o...
Strategies for increasing adherence to physical activity assessments are often linked to extra financial or personal effort. This paper aims to investigate the influence of the recruitment strategy on participants' adherence to accelerometry and resulting PA data. Data were used from two previous studies conducted in 2013 and 2016 in Cologne, Germany, differing in recruitment strategy (N = 103, 40.8% male, mean age 20.9 ± 3.7 years, mean BMI 23.7 ± 4.1 kg/m2). In the passive recruitment (PR) group, vocational students took part in the accelerometry (ActiGraph GT3X+) in line with the main study unless they denied participation. In the active recruitment (AR) group, vocational students were invited to actively volunteer for the accelerometry. Impact of recruitment strategy on adherence and PA data was examined by regression analysis. Average adherence to the accelerometry was 66.7% (AR) and 74.0% (PR). No statistically significant influence of recruitment strategy on adherence and resulting PA was found (allp > 0.05). The difference in recruitment strategy did not affect adherence to accelerometry. The data imply that AR may be applicable. Future studies using larger sample sizes and diverse populations should further investigate these trends.
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- An explanatory model for the concept of mental health in Iranian youth. [Journal Article]
- FF1000Res 2018; 7:52
- Background: Mental health is considered as an integral and essential component of overall health. Its determinants and related factors are one of the most important research prior...
Background: Mental health is considered as an integral and essential component of overall health. Its determinants and related factors are one of the most important research priorities, especially in adolescents and young people. Using a qualitative approach, the present study aimed to identify factors affecting the mental health of youth in Iran.Methods:In 2017, following content analysis principles, and using semi-structured in-depth interviews, we conducted a qualitative study exploring the opinions of young people about mental health. A targeted sampling method was used, and participants were young volunteers aged 18 to 30 who were selected from Tehran province, Iran. Inclusion criteria for participants was willingness to participate in the study, and ability to express their experiences. Data collection was done with individual in-depth interviews. According to the explanatory model, the interviews were directed toward the concept of mental health and path of causality and auxiliary behaviors.Results:21 young adults participated, who met the study inclusion criteria, of whom 12 participants were male. Their mean age was 24.4 ± 0.41 years and their education varied from primary school to Master's degree. Mental health was considered as mental well-being and a sense of satisfaction and efficacy, not only the presence of a disease or mental disorder. Based on the opinions of the interviewees, three factors of personal characteristics, family and society are involved in mental health. Individual factors were associated with behavioral and physical problems. One of the most important issues was revealed as tensions in societal and family conflicts. Economic problems and unemployment of young people were also extracted from the social factor.Conclusion:In Iran, social factors such as jobs for the unemployed and job security are considered as important determinants in the mental health of young people.