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3,180 results
  • Leishmania spp. and leishmaniasis on the Caribbean islands. [Journal Article]
    Trans R Soc Trop Med Hyg 2019Yao C
  • The kinetoplastid protozoan Leishmania spp. cause leishmaniasis, which clinically exhibit mainly as a cutaneous, mucocutanous or visceral form depending upon the parasite species in humans. The disease is widespread geographically, leading to 20 000 annual deaths. Here, leishmaniases in both humans and animals, reservoirs and sand fly vectors on the Caribbean islands are reviewed. Autochthonous h…
  • Amine-binding properties of salivary yellow-related proteins in phlebotomine sand flies. [Journal Article]
    Insect Biochem Mol Biol 2019; :103245Sumova P, Sima M, … Volf P
  • The amine-binding properties of sand fly salivary yellow-related proteins (YRPs) were described only in Lutzomyia longipalpis sand flies. Here, we experimentally confirmed the kratagonist function of YRPs in the genus Phlebotomus. We utilized microscale thermophoresis technique to determine the amine-binding properties of YRPs in saliva of Phlebotomus perniciosus and P. orientalis, the Old-World …
  • Heme synthesis through the life cycle of the heme auxotrophic parasite Leishmania major. [Journal Article]
    FASEB J 2019; :fj201901274RROrrego LM, Cabello-Donayre M, … Pérez-Victoria JM
  • Heme is an essential molecule synthetized through a broadly conserved 8-step route that has been lost in trypanosomatid parasites. Interestingly, Leishmania reacquired by horizontal gene transfer from γ-proteobacteria the genes coding for the last 3 enzymes of the pathway. Here we show that intracellular amastigotes of Leishmania major can scavenge heme precursors from the host cell to fulfill th…
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