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(Pigmented lesions)
6,000 results
  • Shunt surgery for neurocutaneous melanosis with hydrocephalus: case report and review of the literature. [Journal Article]
  • WNWorld Neurosurg 2018 Sep 08
  • Omar AT, Bagnas MAC, … Khu KJO
  • CONCLUSIONS: This case, as well as a review of related literature, suggests that shunt insertion (ventriculoperitoneal or cystoperitoneal) is an effective palliative measure for patients with neurocutaneous melanosis with associated hydrocephalus. Despite treatment, however, the prognosis of these patients remains poor because of malignant progression and leptomeningeal spread of lesions, particularly in cases associated with Dandy-Walker complex.
  • Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia. [Journal Article]
  • PRParkinsonism Relat Disord 2018 Aug 31
  • Iacono D, Geraci-Erck M, … Kurlan R
  • CONCLUSIONS: Unbiased stereology-based measurements of nigral neurons enlargement in manif-DYT1 in the absence of intraneuronal inclusions or neurodegenerative processes, is novel. These findings suggest distinct pathogenetic mechanisms between manif-DYT1 vs. non-manif-DYT1 and manif-non-DYT1 dystonia, especially in terms of possible nigral dopaminergic abnormalities. These data could open new pathophysiologic views on specific dopamino-associated pathomechanisms related to the clinical manifestation of generalized dystonia.
  • The Clinical Spectrum of Cutaneous Melanoma Morphology. [Journal Article]
  • JAJ Am Acad Dermatol 2018 Aug 27
  • Klebanov N, Gunasekera N, … Tsao H
  • CONCLUSIONS: Cluster subdivision yielded diminished sample sizes. Visual assignment was performed without clinical context.When primary cutaneous melanomas were assigned into diagnostic groups and subjected to novel consensus clustering, recurrent morphological patterns emerged. The spectrum of these morphologies was unexpectedly diverse, which may have implications for visual training and possibly clinical diagnosis.
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