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59,850 results
  • RAGE modulatory effects on cytokines network and histopathological conditions in malarial mice. [Journal Article]
    Exp Parasitol. 2020 Jul 02 [Online ahead of print]Chin VK, Chuah YK, … Basir R
  • This study was aimed at investigating the involvement of Receptor for Advanced Glycation End Products (RAGE) during malaria infection and the effects of modulating RAGE on the inflammatory cytokines release and histopathological conditions of affected organs in malarial animal model. Plasmodium berghei (P. berghei) ANKA-infected ICR mice were treated with mRAGE/pAb and rmRAGE/Fc Chimera drugs fro…
  • Experimental transmission of Plasmodium malariae to Anopheles gambiae. [Journal Article]
    J Infect Dis. 2020 Jul 04 [Online ahead of print]Pinilla YT, Boussougou-Sambe ST, … COMAL Study Group
  • Our current knowledge of the clinical burden, biology, and transmission of Plasmodium malariae is extremely scarce. To start addressing some of those questions, we experimentally infected Anopheles gambiae mosquitoes with fresh P. malariae isolates obtained from asymptomatic individuals in Lambaréné, Gabon. The proportion of mosquitoes infected via direct membrane feeding assay with either P. mal…
  • The Genome3D Consortium for Structural Annotations of Selected Model Organisms. [Journal Article]
    Methods Mol Biol. 2020; 2165:27-67.Waman VP, Blundell TL, … Orengo C
  • Genome3D consortium is a collaborative project involving protein structure prediction and annotation resources developed by six world-leading structural bioinformatics groups, based in the United Kingdom (namely Blundell, Murzin, Gough, Sternberg, Orengo, and Jones). The main objective of Genome3D serves as a common portal to provide both predicted models and annotations of proteins in model orga…
  • Rapid activation of distinct members of multigene families in Plasmodium spp. [Journal Article]
    Commun Biol. 2020 Jul 03; 3(1):351.Omelianczyk RI, Loh HP, … Preiser PR
  • The genomes of Plasmodium spp. encode a number of different multigene families that are thought to play a critical role for survival. However, with the exception of the P. falciparum var genes, very little is known about the biological roles of any of the other multigene families. Using the recently developed Selection Linked Integration method, we have been able to activate the expression of a s…
  • When Is a Plasmodium-Infected Mosquito an Infectious Mosquito? [Review]
    Trends Parasitol. 2020 Jun 30 [Online ahead of print]Graumans W, Jacobs E, … Sinnis P
  • Plasmodium parasites experience significant bottlenecks as they transit through the mosquito and are transmitted to their mammalian host. Oocyst prevalence on mosquito midguts and sporozoite prevalence in salivary glands are nevertheless commonly used to confirm successful malaria transmission, assuming that these are reliable indicators of the mosquito's capacity to give rise to secondary infect…
  • Temporospatial shifts within commercial laboratory mouse gut microbiota impact experimental reproducibility. [Journal Article]
    BMC Biol. 2020 Jul 03; 18(1):83.Mandal RK, Denny JE, … Schmidt NW
  • CONCLUSIONS: These changes in gut bacteria may have impacted the experimental reproducibility of diverse research groups and highlight the need for both laboratory animal providers and researchers to collaborate in determining the methods and criteria needed to stabilize the gut microbiota of animal breeding colonies and research cohorts, and to develop a microbiota solution to increase experimental rigor and reproducibility.
  • Species diversity and genome evolution of the pathogenic protozoan parasite, Neospora caninum. [Review]
    Infect Genet Evol. 2020 Jun 30 [Online ahead of print]Calarco L, Ellis J
  • Neospora caninum is a cyst-forming coccidian parasite of veterinary and economical significance, affecting dairy and beef cattle industries on a global scale. Comparative studies suggest that N. caninum consists of a globally dispersed, diverse population of lineages, distinguished by their geographical origin, broad host range, and phenotypic features. This viewpoint is however changing. While i…
  • Pyrethroid and Carbamate Resistance in Anopheles funestus Giles along Lake Kariba in Southern Zambia. [Journal Article]
    Am J Trop Med Hyg. 2020 Jul 02 [Online ahead of print]Chanda J, Saili K, … Sikaala CH
  • Whereas data on insecticide resistance and its underlying mechanisms exist for parts of Zambia, data remain limited in the southern part of the country. This study investigated the status of insecticide resistance, metabolic mechanisms, and parasite infection in Anopheles funestus along Lake Kariba in southern Zambia. Indoor-resting mosquitoes were collected from 20 randomly selected houses withi…
  • Defining multiplicity of vector uptake in transfected Plasmodium parasites. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10894.Carrasquilla M, Adjalley S, … Lee MCS
  • The recurrent emergence of drug resistance in Plasmodium falciparum increases the urgency to genetically validate drug resistance mechanisms and identify new targets. Reverse genetics have facilitated genome-scale knockout screens in Plasmodium berghei and Toxoplasma gondii, in which pooled transfections of multiple vectors were critical to increasing scale and throughput. These approaches have n…
  • Estimation of parasite age and synchrony status in Plasmodium falciparum infections. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10925.Ciuffreda L, Zoiku FK, … Ranford-Cartwright LC
  • Human malaria parasites have complex but poorly understood population dynamics inside their human host. In some but not all infections, parasites progress synchronously through the 48 h lifecycle following erythrocyte invasion, such that at any one time there is a limited spread of parasites at a particular time (hours) post-invasion. Patients presenting with older parasites, and with asynchronou…
  • Targeting histone acetylation/deacetylation in parasites: an update (2017-2020). [Review]
    Curr Opin Chem Biol. 2020 Jun 29; 57:65-74.Fioravanti R, Mautone N, … Mai A
  • Histone modifying enzymes have vital roles in the growth and survival of both parasites and humans. Targeting the epigenome can be a new strategy for the treatment of parasitic diseases. Compounds modulating histone acetylation/deacetylation have recently been reported hampering Plasmodium, Schistosoma, Leishmania, and Trypanosoma infections. Beside new histone deacetylase inhibitors, PfGCN5 and …
  • Genetic Diversity of Anopheles coustani (Diptera: Culicidae) in Malaria Transmission Foci in Southern and Central Africa. [Journal Article]
    J Med Entomol. 2020 Jul 02 [Online ahead of print]Ciubotariu II, Jones CM, … Southern and Central Africa International Centers of Excellence for Malaria Research
  • Despite ongoing malaria control efforts implemented throughout sub-Saharan Africa, malaria remains an enormous public health concern. Current interventions such as indoor residual spraying with insecticides and use of insecticide-treated bed nets are aimed at targeting the key malaria vectors that are primarily endophagic and endophilic. Anopheles coustani s.l., an understudied vector of malaria,…
  • Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities. [Journal Article]
    Chem Pharm Bull (Tokyo). 2020; 68(7):671-674.Boonyaketgoson S, Du Y, … Trisuwan K
  • Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sa…
  • Combined CADD and Virtual Screening to Identify Novel Nonpeptidic Falcipain-2 Inhibitors. [Journal Article]
    Curr Comput Aided Drug Des. 2020 Jul 01 [Online ahead of print]Rajguru T, Bora D, Modi MK
  • CONCLUSIONS: The selected compounds 2-(benzylamino)-8-methylquinoline-3-carbaldehyde (PubChem44138738), 6- bromo-2-(3,4-dihydro-1H-isoquinolin-2-yl)quinoline-3-carbaldehyde (PubChem 20983198), 2-(3,4-dihydro-1Hisoquinolin-2-yl)-6-ethylquinoline-3-carbaldehyde(PubChem20983081)and 2-[benzyl(methyl)amino]quinoline-3- carbaldehyde (PubChem 28951461) may be the starting point for further modification as a new type of nonpeptidic drug for malaria disease.
  • ABO Phenotype and Death in Critically Ill Patients with COVID-19. [Letter]
    Br J Haematol. 2020 Jul 01 [Online ahead of print]Leaf RK, Al-Samkari H, … Leaf DE
  • Blood groups are inherited traits that vary across populations, likely due to both founder effects and natural selection. A link between blood groups and susceptibility to infectious disease has been well-described, with notable examples being H. Pylori and Plasmodium falciparum infection. Blood group antigens may influence disease susceptibility by several mechanisms, including serving as recept…
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