- [Measurement of rifampicin concentrations in tuberculous pleural effusion before and after combination treatment with oral and local rifampicin]. [Journal Article]
- ZJZhonghua Jie He He Hu Xi Za Zhi 2018 Nov 12; 41(11):853-856
- Objective: To investigate the changes of rifampin concentrations in pleural effusion before and after combination treatment with oral and pleural administration of rifampicin by electro-phonophoresi...
Objective: To investigate the changes of rifampin concentrations in pleural effusion before and after combination treatment with oral and pleural administration of rifampicin by electro-phonophoresis(EP). Methods: A self-control study was performed in 32 cases of tuberculous pleurisy treated in the Second Department of Respiratory Medicine of Affiliated Hospital of Zunyi Medical College between September 2016 and January 2018. Based on the weight of each patient, an oral administration of isoniazid (0.3-0.4 g/d), rifampicin (0.45-0.60 g/d),ethambutol(0.75 g/d),and pyrazinamide (1.0-1.5 g/d) were given. After a 5-day traditional anti-tuberculosis treatment, an additional EP treatment was applied by penetrating chest wall to deliver 3 ml of rifampicin. The concentration of rifampicin in 5 ml pleural effusion was measured at 0, 0.5, 1, 2, 4 and 8h after applying EP treatment using high performance liquid chromatography. The measurement data were analyzed by using statistic software SPSS 20.0. The results were expressed by x±s and t test was conducted, with a statistical significance of P<0.05. Results: The average concentration of rifampicin in pleural effusion was (2.2±1.1) μg/ml by oral rifampicin alone. The concentration of rifampicin was (2.7±1.1) μg/ml, (3.0±1.4) μg/ml, (3.2±1.2) μg/ml, (2.8±1.2) μg/ml and (1.3±1.1) μg/ml, respectively, at 0.5 h, 1, 2, 4, 8 h after combining local EP treatment. The results indicated that combining local EP treatment significantly increased the drug concentration in pleural effusion, which lasted for about 5 hours. Conclusions: By applying rifampicin into pleural cavity through EP treatment with penetration of the chest wall, the concentration of rifampicin in pleural effusion of patients with tuberculous pleurisy could be increased. Combined with oral administration of rifampicin, this treatment could prolong the effective drug concentration in pleural effusion, which was beneficial to the bactericidal effects of rifampicin.
- Pharmacological Study of Anti-inflammatory Activity of Aqueous Extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker). [Journal Article]
- JEJ Ethnopharmacol 2018 Nov 08
- CONCLUSIONS: The variation of the results of the anti-inflammatory activity found in M. glomerata and M. laevigata demonstrates that these two species should not be used interchangeably. Coumarin, as already proven, has anti-inflammatory action however, we have suggested that it probably is not the only component responsible for this therapeutic effect in the extracts.
- A case report of granulomatous polyangiitis complicated by tuberculous lymphadenitis. [Journal Article]
- MMedicine (Baltimore) 2018; 97(43):e12430
- CONCLUSIONS: This is the first report of GPA complicated by TB infection. When we encounter a case with rapidly progressive renal failure during the TB infection, complication of GPA should be suspected as 1 of the different diagnosis.
- What happens to migrant tuberculosis patients who are transferred out using a web-based system in China? [Journal Article]
- PlosPLoS One 2018; 13(11):e0206580
- CONCLUSIONS: Web-based transfer helped as the delay and attrition during the transfer interval was quite short and treatment outcomes of more than four-fifths of transferred out migrant TB patients were available with transfer-out BMU. Once strategies to address the independent predictors of 'not evaluated' treatment outcome are devised, China may consider mandatory use of web-based TBIMS for transferring out migrant TB patients.
- Significance of congestive heart failure as a cause of pleural effusion: Pilot data from a large multidisciplinary teaching hospital. [Journal Article]
- CJCardiol J 2018 Nov 08
- CONCLUSIONS: Pleural effusion was found in 10.1% of patients treated in a large multidisciplinary hospital. CHF was the leading cause of PE. Although 30-day mortality in patients with CHF was relatively high, it was lower than that in parapneumonic PE and MPE.
- Anti-inflammatory action of an alkaloid, fraction and extract from Alchornea glandulosa in mice. [Journal Article]
- JEJ Ethnopharmacol 2018 Nov 02
- CONCLUSIONS: To the best of our knowledge, these results are the first to demonstrate that A. glandulosa exhibits oral and topical anti-inflammatory activity. This study detected alkaloid and phenol/polyphenolic compounds in A. glandulosa, which may help to explain the ethnobotanical use of this plant in traditional medicine in Brazil to treat immune-mediated inflammatory diseases.
- Competence in pleural procedures. [Journal Article]
- PMPanminerva Med 2018 Oct 31
- Diseases of the pleura and pleural space are common and present a significant contribution to the workload of respiratory physicians, accounting for an annual incidence of more than 1.5 million cases...
Diseases of the pleura and pleural space are common and present a significant contribution to the workload of respiratory physicians, accounting for an annual incidence of more than 1.5 million cases in the US with the majority of cases resulting from congestive heart failure, pneumonia, and cancer 1. Although the radiographic and ultrasonographic detection of pleural abnormalities may be obvious, the determination of a specific diagnosis can often represent a challenge. Since pleural effusions can develop as the result of over 50 different pleuropulmonary or systemic disorders, determining the cause of a pleural effusion can be greatly facilitated by the analysis of the pleural fluid obtained during an ultrasound guided thoracentesis. Invasive procedures such as ultrasound/CT-guided pleural biopsy or medical thoracoscopy can be useful in selected patients. The knowledge of the etiology and of the management of primary and secondary spontaneous pneumothorax is mandatory in an interventional pulmonology training programme, while the medical or surgical treatment of the recurrence is still a matter of discussion. Pleural drainage is a diagnostic and therapeutic procedure used in the treatment of pneumothorax and large pleural effusions, pleural infections and in neoplastic pleural effusions. Pleural drainage could be a useful tool in the management of hemothorax 2. In neoplastic pleural effusions indications for pleurodesis drainage are: effusion-induced symptoms (dyspnoea) which regress after thoracentesis, recurrent effusion, a reasonably good life expectancy, re-expandable lung 3. Medical thoracoscopy (MT) is a minimally invasive procedure aimed at inspect the pleural space. It could be a diagnostic procedure in: - pleural effusions of indeterminate origin. - malignancy with pleural effusion and malignant mesothelioma. - tuberculous pleurisy and loculated parapneumonic effusion. - staging of pneumothorax. MT is a therapeutic procedure in: - talc poudrage pleurodesis in malignant pleural effusions, in chronic recurrent non-malignant pleural effusions or in pneumothorax. - opening of loculations in parapneumonic effusions and empyema 4. Diagnostic yield is 95% in patients with pleural malignancies and higher in pleural tuberculosis 5,6. In parapneumonic complex effusion, MT obviates the need for surgery in most cases 7. Thoracoscopy training should be considered as being just as important as bronchoscopy training for doctors specializing in interventional pneumology, although prior acquisition of ultrasonography and chest tube insertion skills is essential.
- IgG4-Related Pleuritis Without Tuberculous Pleurisy. [Letter]
- AJAm J Med Sci 2018 Aug 28
- [Good Controlled Chylothorax in Gastric Carcinoma]. [Journal Article]
- GTGan To Kagaku Ryoho 2018; 45(10):1449-1451
- Chylothorax has been reported to be caused by accidental injuries in half of all cases in Japan, and < 10% of these cases have been associated with malignant tumors, including lymphoma. Chylothorax i...
Chylothorax has been reported to be caused by accidental injuries in half of all cases in Japan, and < 10% of these cases have been associated with malignant tumors, including lymphoma. Chylothorax is a rare complication of gastric carcinoma. We successfully treated a 58-year-old man with gastric carcinoma, chylothorax, and ascites using a combination of talc pleurodesis and a lipid-limited diet. Case: A 58-year-old man with advanced stage of poorly differentiated gastric adenocarcinoma presented to our hospital with complaints of shortness of breath. Whole-body computerized tomographic images suggested massive pleural effusion and ascites. Examination of pleural fluid and ascites revealed elevated serum triacylglycerol levels of up to 913mg/dL with numerous free-floating cancer cells. Malignant chylothorax was diagnosed. A lipid-limited diet and octreotide were started, followed by talc pleurodesis for pleural effusion. The patient with controlled pleurisy died of gastric cancer on day 55 after pleurodesis.
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- Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-β-D-Glucopyranoside from Pfaffia townsendii (Amaranthaceae). [Journal Article]
- EBEvid Based Complement Alternat Med 2018; 2018:6057579
- Brazilian ginseng, including Pfaffia townsendii, is used in popular medicine as a natural anti-inflammatory, tonic, analgesic, and antidiabetic agent. In this study, we investigated the chemical comp...
Brazilian ginseng, including Pfaffia townsendii, is used in popular medicine as a natural anti-inflammatory, tonic, analgesic, and antidiabetic agent. In this study, we investigated the chemical composition and evaluated the antioxidant and anti-inflammatory activities of the P. townsendii ethanolic extract as well as the major isolated glycoside flavonoids tiliroside and patuletin 3-O-β-D-glucopyranoside. Chromatographic techniques and spectroscopic analysis were used for the isolation and identification of the major compounds. The antioxidant potential was determined through DPPH and ORAC-FL assays. The total phenolic content was measured using Folin-Ciocalteu reagent. The anti-inflammatory activity was determined based on a model of paw edema and carrageenan- (Cg-) induced pleurisy. We identified three phenolic acids, one carboxylic acid and two flavonoids, patuletin 3-O-β-D-glucopyranoside, and tiliroside. The ethanol crude extracts, partitions and isolated flavonoids (4581 μmol of Trolox equivalents/g of extract in ORAC and a SC50 of approximately 31.9 μg/mL in the DPPH assay) demonstrated antioxidant activity, and the ethanolic extract as well as isolated flavonoids inhibited paw edema induced by Cg and leukocyte migration in the Cg-induced pleurisy model. The extract, tiliroside, and patuletin 3-O-β-D-glucopyranoside obtained from P. townsendii have therapeutic potential against oxidative stress-related and inflammatory disorders.