- Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus: first-in-human trial. [Journal Article]
- ICIntensive Care Med 2018 Oct 21
- CONCLUSIONS: Adjunctive treatment of severe S. aureus HABP with anti-staphylococcal mAbs appears feasible and suggests some clinical benefits, but larger randomized studies are needed to better define its safety and efficacy.
- Prevention of early ventilation-acquired pneumonia (VAP) in comatose brain-injured patients by a single dose of ceftriaxone: PROPHY-VAP study protocol, a multicentre, randomised, double-blind, placebo-controlled trial. [Journal Article]
- BOBMJ Open 2018 Oct 18; 8(10):e021488
- Ventilator-associated pneumonia (VAP) is the first cause of healthcare-associated infections in intensive care units (ICUs) and brain injury is one of the main risk factors for early-onset VAP. Antib...
Ventilator-associated pneumonia (VAP) is the first cause of healthcare-associated infections in intensive care units (ICUs) and brain injury is one of the main risk factors for early-onset VAP. Antibiotic prophylaxis has been reported to decrease their occurrence in brain-injured patients, but a lack of controlled randomised trials and the risk of induction of bacterial resistance explain the low level of recommendations. The goal of this study is to determine whether a single dose of ceftriaxone within the 12 hours postintubation after severe brain injury can decrease the risk of early-onset VAP.
- An assessment of potential unintended consequences following a national antimicrobial stewardship programme in England: an interrupted time series analysis. [Journal Article]
- CIClin Infect Dis 2018 Oct 18
- CONCLUSIONS: Findings from this study show that overall there was no significant association between the intervention and unintended clinical consequences, with the exception of a few specific conditions, most of which could be explained through other parallel policy changes or should be interpreted with caution due to small numbers.
- The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: a case-control study. [Journal Article]
- TThorax 2018 Oct 18
- CONCLUSIONS: Respiratory viruses, particularly RSV and HMPV, are major contributors to pneumonia in Australian children.
- Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-Acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene: A Case Report. [Journal Article]
- IMIntern Med 2018 Oct 17
- A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation...
A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes encoding Panton-Valentine leucocidin (PVL). CA-MRSA necrotizing pneumonia with the PVL gene is rare; only three cases have been previously reported in Japan. We administered anti-MRSA antibiotics and the patient achieved complete clinical and radiological improvement.
- Clinical, epidemiological, and etiological profile of inpatients with community-acquired pneumonia in a public hospital in the interior of Brazil. [Journal Article]
- JBJ Bras Pneumol 2018 Jul-Aug; 44(4):261-266
- To describe the patient profile, mortality rates, the accuracy of prognostic scores, and mortality-associated factors in patients with community-acquired pneumonia (CAP) in a general hospital in Braz...
To describe the patient profile, mortality rates, the accuracy of prognostic scores, and mortality-associated factors in patients with community-acquired pneumonia (CAP) in a general hospital in Brazil.
- Community-acquired pneumonia: challenges of the situation in Brazil. [Editorial]
- JBJ Bras Pneumol 2018 Jul-Aug; 44(4):254-256
- Nonalcoholic fatty liver disease and 30-day all-cause mortality in adult patients with community-acquired pneumonia. [Journal Article]
- QJMQJM 2018 Oct 16
- CONCLUSIONS: NAFLD was associated with 30-day all-cause mortality in patients with CAP. This association was more significant in patients with advanced hepatic fibrosis.
- Long-Term Use of Proton Pump Inhibitors and Community-Acquired Pneumonia: Adverse Effect or Bias? [Letter]
- JAJ Am Geriatr Soc 2018 Oct 16
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- Lower neutrophil-to-lymphocyte ratio predicts high risk of multidrug-resistant Pseudomonas aeruginosa infection in patients with hospital-acquired pneumonia. [Journal Article]
- TCTher Clin Risk Manag 2018; 14:1863-1869
- CONCLUSIONS: We have shown that lower NLR level was identified as a clinical predictor of MDR-PA infection in HAP patients. Even with goal-directed therapy, MDR-PA infection implicates poor outcomes in patients with HPA.