- Insight into the local source of polybrominated diphenyl ethers in the developing Tibetan Plateau: The composition and transport around the Lhasa landfill. [Journal Article]
- EPEnviron Pollut 2018 Feb 18; 237:1-9
- In the background region of the Tibetan Plateau (TP), the rapid urbanization probably results in the massive generation of persistent organic pollutants (POPs), which lacks monitoring and evaluation....
In the background region of the Tibetan Plateau (TP), the rapid urbanization probably results in the massive generation of persistent organic pollutants (POPs), which lacks monitoring and evaluation. Since landfill could serve as an important sink of the locally used POPs, the analysis of POPs in the Tibetan landfill area might help us to understand the source composition and their transport in the TP. In this study, the concentration variations of polybrominated diphenyl ethers (PBDEs) in five soil profiles and seven surficial sediments around the largest Tibetan landfill were investigated. The total concentrations of PBDEs ranged from 128 to 1219 ng/kg in soils, and from 447 to 7295 ng/kg in sediments. The dominance of nona- and deca-BDEs possibly indicated the wide usage of deca-BDE as flame retardant in the TP. The vertical and spatial distribution patterns of PBDEs within soils plausibly revealed their main transport pathways by atmospheric dispersion and leachate seepage from landfill. Based on principal components analysis and multiple linear regression, these two pathways were estimated to account for 61% and 39% of the total concentrations, respectively. Additionally, the spatial and vertical distributions of octa-to deca-BDEs within soils were significantly influenced by soil particle size. Although the PBDEs inventory in the study area was comparatively low, the rapid urbanization in the TP might dramatically accelerate the PBDE emissions in the future. This study firstly introduced the presence of local PBDEs in the TP, and the inventory already influenced the surrounding environment. Once involved in the regional cycle of the TP, the local source of PBDEs from waste might significantly serve to raise background level resulting otherwise primarily from long-range atmospheric transport.
- Association of Hippocampal Atrophy With Duration of Untreated Psychosis and Molecular Biomarkers During Initial Antipsychotic Treatment of First-Episode Psychosis. [Journal Article]
- JPJAMA Psychiatry 2018 Feb 21
- CONCLUSIONS: An association between longer DUP and accelerated hippocampal atrophy during initial treatment suggests that psychosis may have persistent, possibly deleterious, effects on brain structure. Additional studies are needed to replicate these exploratory findings of molecular mechanisms by which untreated psychosis may affect hippocampal volume and to determine whether these effects account for the known association between longer DUP and poor outcome.
- Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice. [Journal Article]
- PlosPLoS One 2018; 13(2):e0193012
- Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels are important regulators of excitability in neural, cardiac, and other pacemaking cells, which are often altered in disease. In mice...
Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels are important regulators of excitability in neural, cardiac, and other pacemaking cells, which are often altered in disease. In mice, loss of HCN2 leads to cardiac dysrhythmias, persistent spike-wave discharges similar to those seen in absence epilepsy, ataxia, tremor, reduced neuropathic and inflammatory pain, antidepressant-like behavior, infertility, and severely restricted growth. While many of these phenotypes have tissue-specific mechanisms, the cause of restricted growth in HCN2 knockout animals remains unknown. Here, we characterize a novel, 3kb insertion mutation of Hcn2 in the Tremor and Reduced Lifespan 2 (TRLS/2J) mouse that leads to complete loss of HCN2 protein, and we show that this mutation causes many phenotypes similar to other mice lacking HCN2 expression. We then demonstrate that while TRLS/2J mice have low blood glucose levels and impaired growth, dysfunction in hormonal secretion from the pancreas, pituitary, and thyroid are unlikely to lead to this phenotype. Instead, we find that homozygous TRLS/2J mice have abnormal gastrointestinal function that is characterized by less food consumption and delayed gastrointestinal transit as compared to wildtype mice. In summary, a novel mutation in HCN2 likely leads to impaired GI motility, causing the severe growth restriction seen in mice with mutations that eliminate HCN2 expression.
- Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. [Journal Article]
- PlosPLoS One 2018; 13(2):e0193051
- CONCLUSIONS: Recanalization rates in acute basilar occlusion after IVT alone are low and dependent on thrombus length. Additional mechanical endovascular thrombectomy showed to be a very successful recanalization therapy.
- Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection. [Journal Article]
- PlosPLoS One 2018; 13(2):e0192883
- CONCLUSIONS: Dynamics of mHLA-DR varied according to the bacterial etiology of infection, with delayed recovery in patients with S. aureus BSI. Patients with negative outcome showed sustained CRP elevation, neutrophilia, lymphocytopenia, and low levels of mHLA-DR, supporting the theory of a dysregulated host response with persistent inflammation and immunosuppression in late stages of deleterious sepsis.
- Persistent injury-associated anemia and aging: Novel insights. [Journal Article]
- JTJ Trauma Acute Care Surg 2018; 84(3):490-496
- CONCLUSIONS: Compared with young rats, aged rats had less HPC mobilization despite elevated basal and peak norepinephrine. Aged rats were disproportionately affected by impaired hematopoietic progenitor growth and an iron-restricted red blood cell phenotype at baseline, which persisted 7 days after injury. Further research is needed to assess how the clinical approach to persistent injury-associated anemia should differ for elderly trauma patients.
- [Incidence of sinus node dysfunction in patients with long-standing, persistent atrial fibrillation who require simultaneous surgical correction of mitral and tricuspid valve defects and the "Maze IIIB" procedure]. [Journal Article]
- KKardiologiia 2017 SMar; 57(S3):40-48
- CONCLUSIONS: Effectiveness of the surgical treatment for persistent and long-standing persistent AF (modified "Maze IIIB" surgery with simultaneous correction of the mitral valve (MV) and the tricuspid valve (TV)) in the early postsurgery period was 95 %. According to data of preoperative endocardial EPS, SAND was observed in 13 % of patients. Following the surgical correction of MV and TV defects and the criomodification of the "Maze IIIB" surgery, signs of SAND requiring implantation of an electric cardioverter were observed in a total of 24 % of patients.
- [Anticoagulant therapy and prognosis in patients with CHF and AF in the setting of real-life clinical practice]. [Journal Article]
- KKardiologiia 2017 SApr; 57(S4):4-10
- Prevalence of atrial fibrillation (AF) grows with the increase in CHF FC and reaches 45% in III-IV FC CHF. With an adequate anticoagulant (AC) therapy, the risk of thromboembolic complications does n...
Prevalence of atrial fibrillation (AF) grows with the increase in CHF FC and reaches 45% in III-IV FC CHF. With an adequate anticoagulant (AC) therapy, the risk of thromboembolic complications does not significantly differ between patients with I-II FC and III-IV FC CHF. Of particular interest is studying administration of the anticoagulant treatment and correspondence between the SAMe-TT2R2 scale and actual TTR values in patients with CHF and AF in real-life clinical practice.
- A Modified Technique to Create a Standardized Floppy Nissen Fundoplication Without a Bougie. [Journal Article]
- JLJ Laparoendosc Adv Surg Tech A 2018 Feb 21
- CONCLUSIONS: This modified method for standardized Nissen fundoplication is safe and might reduce postoperative dysphagia. Quality of life after 1 year is excellent. The effect on postoperative dysphagia and the reproducibility of this technique should be established in a large prospective study.
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- Laparoscopic Nissen Fundoplication: An Excellent Treatment of Gerd-Related Respiratory Symptoms in Children-Results of a Multicentric Study. [Journal Article]
- JLJ Laparoendosc Adv Surg Tech A 2018 Feb 21
- CONCLUSIONS: Our results confirm that GERD should be investigated as one of the possible etiologic factors in any child with persistent respiratory complaints. In patients with symptoms not responsive to medical therapy, laparoscopic Nissen fundoplication is the treatment of choice with a very high success rate (>90% in our series), a very low morbidity, a significant improvement in airway symptoms, and a marked reduction in the need for medications.