- [Disorders of heart structure and function parameters and hepatolienal blood flow remodeling in patients with virus-induced cirrhosis]. [Journal Article]
- KKardiologiia 2017 SMar; 57(S3):57-61
- To study heart structure and function parameters and hepatolienal blood flow in patients with virus-induced cirrhosis (VIC).
To study heart structure and function parameters and hepatolienal blood flow in patients with virus-induced cirrhosis (VIC).
- Postoperative hemorrhage caused by portal hypertension associated with autoimmune pancreatitis: A case report. [Journal Article]
- MMedicine (Baltimore) 2018; 97(8):e9982
- CONCLUSIONS: In this study, we present the case of repeated postoperative hemorrhage (9 and 16 mos). We discussed the correlation between postoperative hemorrhage and autoimmune pancreatitis, and the cause of postoperative hemorrhage.
- A study on risk factors and diagnostic efficiency of posthepatectomy liver failure in the nonobstructive jaundice. [Journal Article]
- MMedicine (Baltimore) 2018; 97(8):e9963
- Liver failure remains as the most common complication and cause of death after hepatectomy, and continues to be a challenge for doctors.t test and χ test were used for single factor analysis of data-...
Liver failure remains as the most common complication and cause of death after hepatectomy, and continues to be a challenge for doctors.t test and χ test were used for single factor analysis of data-related variables, then results were introduced into the model to undergo the multiple factors logistic regression analysis. Pearson correlation analysis was performed for related postoperative indexes, and a diagnostic evaluation was performed using the receiver operating characteristic (ROC) of postoperative indexes.Differences in age, body mass index (BMI), portal vein hypertension, bile duct cancer, total bilirubin, alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), operation time, cumulative portal vein occlusion time, intraoperative blood volume, residual liver volume (RLV)/entire live rvolume, ascites volume at postoperative day (POD)3, supplemental albumin amount at POD3, hospitalization time after operation, and the prothrombin activity (PTA) were statistically significant. Furthermore, there were significant differences in total bilirubin and the supplemental albumin amount at POD3. ROC analysis of the average PTA, albumin amounts, ascites volume at POD3, and their combined diagnosis were performed, which had diagnostic value for postoperative liver failure (area under the curve (AUC): 0.895, AUC: 0.798, AUC: 0.775, and AUC: 0.903).Preoperative total bilirubin level and the supplemental albumin amount at POD3 were independent risk factors. PTA can be used as the index of postoperative liver failure, and the combined diagnosis of the indexes can improve the early prediction of postoperative liver failure.
- A new prognostic score can predict survival after hepatocellular carcinoma treatment in a cohort of 1302 Egyptian hepatocellular carcinoma patients. [Journal Article]
- EJEur J Gastroenterol Hepatol 2018 Feb 20
- CONCLUSIONS: A new Egyptian prognostic score of tumor and patients factors can predict the survival of patients with HCC after palliative and curative treatments.
- Noncirrhotic portal hypertension. [Journal Article]
- COCurr Opin Gastroenterol 2018 Feb 19
- CONCLUSIONS: Noncirrhotic portal hypertension is an underappreciated clinical entity that can be difficult to diagnosis without a healthy suspicion. Diagnosis then relies on a comprehensive understanding of the causes and clinical manifestations of this disease, as well as a careful interpretation of the liver biopsy. Noninvasive approaches to diagnosis may play a significant role moving forward in this disease. Treatment in NCPH remains largely targeted at the individual sequalae of portal hypertension.
- Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease. [Journal Article]
- HHistopathology 2018 Feb 21
- CONCLUSIONS: We describe a simple and reproducible method for elastin quantification in liver biopsies that provides potentially valuable prognostic information to inform clinical management. This article is protected by copyright. All rights reserved.
- Idiopathic portal hypertension and extrahepatic portal venous obstruction. [Review]
- HIHepatol Int 2018 Feb 20
- CONCLUSIONS: This review gives a detailed summary of these two vascular conditions of liver-IPH and EHPVO. Further research is needed to understand the pathogenesis and natural history of these disorders.
- Hepatic and cardiac hemodynamics and systemic inflammation in cirrhosis: it takes three to tango. [Editorial]
- JHJ Hepatol 2018 Feb 17
- In this editorial the roles of systemic inflammation, elevated pressure in portal venous system and heart function and circulation in stable cirrhosis and decompensated cirrhosis with or without orga...
In this editorial the roles of systemic inflammation, elevated pressure in portal venous system and heart function and circulation in stable cirrhosis and decompensated cirrhosis with or without organ failures are described.
- Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension. [Journal Article]
- KJKorean J Intern Med 2018 Feb 21
- The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1-7), angiot...
The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), and Ang II type 1 receptor (AT1R) are increased. The primary effector Ang II regulates vasoconstriction, sodium homoeostasis, fibrosis, cell proliferation, and inflammation in various diseases, including liver cirrhosis, through the ACE/Ang II/AT1R axis in the classical RAS. The ACE2/Ang-(1-7)/Mas receptor and ACE2/Ang-(1-9)/AT2R axes make up the alternative RAS and promote vasodilation, antigrowth, proapoptotic, and anti-inflammatory effects; thus, countering the effects of the classical RAS axis to reduce hepatic fibrogenesis and portal hypertension. Patients with portal hypertension have been treated with RAS antagonists such as ACE inhibitors, Ang receptor blockers, and aldosterone antagonists, with very promising hemodynamic results. In this review, we examine the RAS, its roles in hepatic fibrosis and portal hypertension, and current therapeutic approaches based on the use of RAS antagonists in patients with portal hypertension.
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- Transjugular intrahepatic portosystemic shunt creation for cirrhotic portal hypertension is well tolerated among patients with portal vein thrombosis. [Journal Article]
- EJEur J Gastroenterol Hepatol 2018 Feb 16
- CONCLUSIONS: The presence of PVT does not impair the prognosis of patients following TIPS creation, particularly in patients with distal portal occlusion.