- Incidence and Severity of Sexual Harassment, and its Impact on Mental Health in a Cohort of International Humanitarian Field-Workers. [Journal Article]J Interpers Violence. 2023 Feb 07 [Online ahead of print]JI
- To date, there have been no cohort studies of sexual harassment incidence and its relation to mental health within humanitarian field-workers. Research among numerous occupations suggests an association between workplace sexual harassment and several health complaints. This study examined the incidence and severity of sexual harassment and its association with changes in mental health in a cohort…
- Publisher Full Text (DOI)
- Promoter methylation of the glucocorticoid receptor following trauma may be associated with subsequent development of PTSD. [Journal Article]World J Biol Psychiatry. 2023 Feb 07 [Online ahead of print]WJ
- CONCLUSIONS: To the extent that reduced promoter methylation is associated with greater GR expression and responsivity, this finding is consistent with the hypothalamic-pituitary-adrenal dysregulation previously described for PTSD.
- Publisher Full Text (DOI)
- Health related quality of life of HIV-positive women on ART follow-up in north Shewa zone public hospitals, central Ethiopia: Evidence from a cross-sectional study. [Journal Article]Heliyon. 2023 Feb; 9(2):e13318.H
- CONCLUSIONS: This study reveals a high magnitude of poor HRQoL among HIV-positive women. Therefore, as HRQoL domains are comprehensive indicators of living status, healthcare service providers should be dedicated to screening and supporting HIV-positive women with poor HRQoL. Additionally, healthcare providers should also pay special attention to routine PTSD screening and management for HIV-positive women due to its detrimental effect on HRQoL.
- PMC Free PDF
- Providing Human Support for the Use of Digital Mental Health Interventions: Systematic Meta-review. [Review]J Med Internet Res. 2023 Feb 06; 25:e42864.JM
- CONCLUSIONS: Our findings highlight the potential of human support in improving the effects of DMHIs. Specifically, evidence emerged for stronger effects of human support for individuals with greater symptom severity. There was considerable heterogeneity across meta-analyses in the level of detail regarding the nature of the interventions, population served, and support delivered, making it difficult to draw strong conclusions regarding the circumstances under which human support is most effective. Future research should emphasize reporting detailed descriptions of sample and intervention characteristics and describe the mechanism through which they believe the coach will be most useful for the DMHI.
- Publisher Full Text (DOI)
- World Trade Center Health Program best practices for the diagnosis and treatment of gastroesophageal reflux disease. [Journal Article]Arch Environ Occup Health. 2023 Feb 06 [Online ahead of print]AE
- Gastroesophageal reflux disease (GERD) is one of the most common health conditions reported among persons exposed to the dust, debris and chemicals after the September 11, 2001 attacks in the United States. In the 9/11-exposed population, GERD is often found to be co-morbid with other conditions, such as asthma, post-traumatic stress disorder, and obesity. High-quality clinical practice guideline…
- Publisher Full Text (DOI)
- Dissociation Among Women with Chronic Pelvic Pain: Relation to Surgical Treatment, Pelvic Pain Severity, and Health-Related Quality of Life. [Journal Article]J Trauma Dissociation. 2023 Mar-Apr; 24(2):296-311.JT
- Chronic pelvic pain (CPP) is associated with a history of trauma and symptoms of somatoform dissociation. We aimed to describe how somatoform dissociation impacts CPP symptoms, surgical treatment, and health-related quality of life (HRQOL). Patients (N = 133) diagnosed with CPP presenting for an appointment at a women's health clinic between November, 2019 - July, 2021 were recruited to participa…
- Publisher Full Text (DOI)
- [Resource-Oriented Narrative TraumaTherapy (Resonat): Treating Complex Trauma Disorders in Children and Adolescents Gently and Specifically]. [Journal Article]Prax Kinderpsychol Kinderpsychiatr. 2023 Feb; 72(2):96-112.PK
- Resource-oriented narrative trauma therapy (ResonaT; Hiller u. Hensel, 2019) is an innovative and creative approach within existing narrative trauma procedures. It is based on the three core elements of modern trauma therapy (actualisation, resource activation, dual attention) and invokes the neurobiological self-healing mechanism of memory reconsolidation. Due to its low demands on the children,…
- Publisher Full Text (DOI)
- Delirium-related psychiatric and neurocognitive impairment and the association with post intensive care syndrome- a narrative review. [Review]Acta Psychiatr Scand. 2023 Feb 06 [Online ahead of print]AP
- CONCLUSIONS: Delirium is a complex but common phenomenon in the ICU and a risk factor for PICS. Its diagnosis is challenging with potential long-term adverse outcomes, including psychiatric and cognitive difficulties. The implementation of screening and follow-up protocols for PICS sequelae is warranted to ensure early detection and appropriate management.
- Publisher Full Text (DOI)
- Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults. [Journal Article]
- Neuroimaging and biomarker studies in Alzheimer disease (AD) have shown well-characterized patterns of cortical thinning and altered biomarker concentrations of tau and β-amyloid (Aβ). However, earlier identification of AD has great potential to advance clinical care and determine candidates for drug trials. The extent to which AD risk markers relate to cortical thinning patterns in midlife is un…
- PMC Free PDF
- Medical cannabis for treatment-resistant combat PTSD. [Journal Article]
- Targeting the endocannabinoid system may have a role in the treatment of post-traumatic stress disorder (PTSD). However, few studies have examined the effectiveness of cannabis on symptoms of PTSD, and more research is needed to ascertain cannabis' effectiveness. In this retrospective naturalistic study, we followed 14 relatively mature (32-68 years of age), treatment-resistant, chronic combat po…
- PMC Free PDF
- Post-traumatic stress among COVID-19 survivors: A descriptive study of hospitalized first-wave survivors. [Journal Article]
- CONCLUSIONS: Lung physicians should be aware of the risk of PTSD in patients hospitalized for COVID-19 and ensure appropriate screening and follow-up care.
- PMC Free PDF
- The Effectiveness of Mindfulness-Based Interventions for Police Officers' Stress Reduction: a Systematic Review. [Journal Article]
- The profession of a police officer is associated with high levels of stress, which can have harmful consequences for officers' personal lives, the police organisation, and society. This systematic review aims to synthesise recent literature on the effectiveness of mindfulness-based intervention related to stress reduction (MBIs) in a sample of police officers. The search of relevant articles was …
- PMC Free PDF
- Prevalence and incidence of post-traumatic stress disorder and symptoms in people with chronic somatic diseases: A systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: Post-traumatic stress disorder and PTSS are common and substantially higher in people with compared to those without CD. Earlier detection and treatment of this comorbidity might improve mental and physical health, reduce the incidence of further diseases, and reduce mortality.
- PMC Free PDF
- Potentially Psychologically Traumatic Event Exposure Histories of new Royal Canadian Mounted Police Cadets. [Journal Article]Can J Psychiatry. 2023 Feb 05 [Online ahead of print]CJ
- CONCLUSIONS: The current results provide the first information describing PPTE histories of cadets, evidencing exposure frequencies and types much higher than the general population. PPTE exposures may have contributed to the cadet's vocational choices. The current results support the growing evidence that PPTEs can be associated with diverse mental disorders; however, the results also suggest cadets may be uncommonly resilient, based on how few screened positive for mental disorders, despite reporting higher frequencies of PPTE exposures prior to CTP than the general population.
- Publisher Full Text (DOI)
- Assessment of genetic variants in D2 dopamine receptor (DRD2) gene as risk factors for post-traumatic stress disorder (PTSD) and major depressive disorder (MDD): A systematic review and meta-analysis. [Journal Article]J Affect Disord. 2023 Feb 03 [Online ahead of print]JA
- CONCLUSIONS: This meta-analysis indicated that genetic variants in the DRD2 gene might potentially contribute to genetic susceptibility for PTSD and MDD. The utilization of DRD2 genetic variants as risk factors for PTSD and MDD requires further validation by large well-designed case-control studies.
- Publisher Full Text (DOI)
- Prefrontal cortex neurons in adult rats exposed to early life stress fail to appropriately signal the consequences of motivated actions. [Journal Article]Physiol Behav. 2023 Feb 03 [Online ahead of print]PB
- Early life stress (ELS) can set the stage for susceptibility to cognitive and emotional dysfunction in adulthood by disrupting typical neural development. The prefrontal cortex (PFC) continues to mature during early life, making this region particularly vulnerable to disruption for animals who experience ELS. Despite this, the effects of ELS experience on in vivo PFC function in awake and behavin…
- Publisher Full Text (DOI)
- Risk factors of post-traumatic stress disorder after hospitalization in a pediatric intensive care unit: a systematic literature review. [Review]Eur Child Adolesc Psychiatry. 2023 Feb 05 [Online ahead of print]EC
- The number of studies on post-traumatic stress disorder after hospitalization in a pediatric intensive care unit raised since 2004. The objective of this systematic review was to summarize and critically examine the literature about risk factors for these children to develop post-traumatic stress disorder following admission to an intensive care unit. The data sources were PubMed, Cochrane, Web o…
- Publisher Full Text (DOI)
- Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women. [Randomized Controlled Trial]
- Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of post-traumatic stress disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investigates the effect of the activation of the oxytocin system during the consolidation of an analogue trauma on …
- PMC Free PDF
- Appearance of extrapyramidal symptoms in adolescent psychiatry patients during Covid-19 infection. [Journal Article]J Med Virol. 2023 Feb 04 [Online ahead of print]JM
- Since the start of the pandemic, there has been an increase in the incidence of psychiatric morbidity among those infected with COVID-19 and those indirectly affected by COVID-19. There has been a considerable increase in the number of individuals with such psychiatric conditions as depression, acute stress disorders, anxiety, and post-traumatic stress disorder (PTSD). About one-third of patients…
- Publisher Full Text (DOI)
- The contribution of copy number variants to psychiatric symptoms and cognitive ability. [Review]Mol Psychiatry. 2023 Feb 03 [Online ahead of print]MP
- Copy number variants (CNVs) are deletions and duplications of DNA sequence. The most frequently studied CNVs, which are described in this review, are recurrent CNVs that occur in the same locations on the genome. These CNVs have been strongly implicated in neurodevelopmental disorders, namely autism spectrum disorder (ASD), intellectual disability (ID), and developmental delay (DD), but also in s…
- Publisher Full Text (DOI)
- Persistent physical symptoms after COVID-19 infection and the risk of Somatic Symptom Disorder. [Journal Article]
- CONCLUSIONS: The identification of SSD should encourage clinicians to move beyond the artificial somatic/psychiatric dualism and contribute to a better alliance based on multi-disciplinary care.
- PMC Free PDF
- Reversal of hyperactive higher-order thalamus attenuates defensiveness in a mouse model of PTSD. [Journal Article]Sci Adv. 2023 Feb 03; 9(5):eade5987.SA
- Posttraumatic stress disorder (PTSD) is a highly prevalent and debilitating psychiatric disease often accompanied by severe defensive behaviors, preventing individuals from integrating into society. However, the neural mechanisms of defensiveness in PTSD remain largely unknown. Here, we identified that the higher-order thalamus, the posteromedial complex of the thalamus (PoM), was overactivated i…
- Publisher Full Text (DOI)
- Menstrual symptoms variation among Lebanese women before and after the COVID-19 pandemic. [Journal Article]
- CONCLUSIONS: Our main findings indicate that females had irregular menstrual cycles, unpredictable bleeding pattern, and intense symptoms severity post COVID-19 pandemic. Furthermore, stress post COVID-19 and Beirut blast tended to be associated with increased menstrual symptoms. Thus, vulnerable women should be identified and offered appropriate care, information, and awareness regarding their menstrual period during a pandemic.
- PMC Free PDF
- A generative adversarial model of intrusive imagery in the human brain. [Journal Article]
- The mechanisms underlying the subjective experiences of mental disorders remain poorly understood. This is partly due to long-standing over-emphasis on behavioral and physiological symptoms and a de-emphasis of the patient's subjective experiences when searching for treatments. Here, we provide a new perspective on the subjective experience of mental disorders based on findings in neuroscience an…
- PMC Free PDF
- Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus. [Journal Article]Mol Psychiatry. 2023 Feb 02 [Online ahead of print]MP
- Age, female sex, and apolipoprotein E4 (E4) are risk factors to develop Alzheimer's disease (AD). There are three major human apoE isoforms: E2, E3, and E4. Compared to E3, E4 increases while E2 decreases AD risk. However, E2 is associated with increased risk and severity of post-traumatic stress disorder (PTSD). In cognitively healthy adults, E4 carriers have greater brain activation during lear…
- Publisher Full Text (DOI)
- Acute stress responses of autonomous nervous system, HPA axis, and inflammatory system in posttraumatic stress disorder. [Journal Article]
- Posttraumatic stress disorder (PTSD) does not only have direct consequences for well-being, but it also comes with a significant risk for severe somatic health consequences. A number of previous studies have pointed to alterations in stress systems in traumatized persons, as well as the inflammatory system, which might be important links in the pathway between trauma, PTSD, and health consequence…
- PMC Free PDF
- [Traumatic motherhood in Covid-19 times]. [Journal Article]Soins Psychiatr. 2022 Nov-Dec; 43(343):32-35.SP
- In the context of maternal vital emergency due to Covid-19, dire situations of birth questioned the health practitioners of a neonatal intensive care unit. How can mothers take care of their baby when their own life has been threatened ? The analysis of two clinical cases underlines the importance of talking for these mothers who have been through disastrous experiences, which could lead to a pos…
- Publisher Full Text (DOI)
- Musculoskeletal health state and physical function of intensive care unit survivors: protocol for a UK multicentre prospective cohort study (the MSK-ICU study). [Journal Article]
- Survivors of critical illness frequently experience long-term physical impairment, decreased health-related quality of life and low rates of return to employment. There has been limited investigation of the underlying problems affecting physical function post-intensive care unit (ICU) admission. Musculoskeletal (MSK) conditions may be complex in presentation, with ICU survivors potentially at gre…
- PMC Free PDF
- COVID-19 stress syndrome in the German general population: Validation of a German version of the COVID Stress Scales. [Journal Article]
- The COVID Stress Scales (CSS) are a new self-report instrument for multidimensional assessment of psychological stress in the context of the pandemic. The CSS have now been translated and validated in over 20 languages, but a validated German version has not yet been available. Therefore, the aim was to develop a German version of the CSS, to test its factor structure, reliability, and validity, …
- PMC Free PDF
- Association of pro-inflammatory cytokines with trauma and post-traumatic stress disorder visiting a tertiary care hospital in Kathmandu. [Journal Article]
- Post-traumatic stress disorder (PTSD) is a mental disorder that can occur after trauma. Although inflammatory markers such as cytokines are found altered in trauma and PTSD, there is no consensus regarding which can be considered as biomarkers. Studies from South Asia region is also rare. We studied cytokines among trauma affected patients and matched healthy controls. Fifty patients (cases) with…
- PMC Free PDF