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(Pregnancy AND anovulation causes of)
714 results
  • Endogenous Cushing's syndrome during pregnancy. [Review]
    Rev Endocr Metab Disord. 2022 Jun 07 [Online ahead of print]Younes N, St-Jean M, … Lacroix A
  • Endogenous Cushing's syndrome (CS) is rare during pregnancy, probably because hypercortisolism induces anovulation and infertility. To date, slightly above 200 cases have been reported in the literature. The most frequent etiology of CS diagnosed during gestation is from primary adrenal causes, namely adrenal adenomas and an entity called pregnancy-induced CS. The latter can be secondary to the a…
  • Evaluation and management of abnormal uterine bleeding. [Journal Article]
    Med J Malaysia. 2022 May; 77(3):374-383.Achanna KS, Nanda J
  • Abnormal uterine bleeding (AUB) is one of the commonest complaints of women in reproductive age and non-gravid state that brings them to the attention of the primary care doctor or the gynaecologist. Anovulation without any medical illness or pelvic pathology seems to be the common cause. Bleeding due to a wide variation in pathology both inside and outside the reproductive tract can be termed as…
  • Current pharmacotherapy and future directions for neuroendocrine causes of female infertility. [Journal Article]
    Expert Opin Pharmacother. 2022 May 10 [Online ahead of print]Koysombat K, Abbara A, Dhillo WS
  • Infertility is recognized as a major global health issue, often associated with significant psychological distress for affected couples. Causes of female infertility include endocrine conditions leading to oligo/anovulation, in addition to structural causes such as tubal, uterine, or peritoneal disorders. Pharmacological treatments, targeting pathways in the hypothalamic-pituitary-ovarian axis, c…
  • The use of metformin in women with polycystic ovary syndrome: an updated review. [Review]
    J Assist Reprod Genet. 2022 Mar; 39(3):573-579.Notaro ALG, Neto FTL
  • CONCLUSIONS: For women with PCOS, metformin is a good adjunctive medication for ovulation induction/stimulation for high and low complexity assisted reproduction therapies. The adverse effects are mostly mild, and there is no risk of teratogenicity, but the risk of long-term complications for the offspring is not yet defined. High heterogeneity of the studies limits extrapolation of findings, and further research is needed to determine which women will benefit most from the medication.
  • Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights. [Journal Article]
    Biol Reprod. 2022 02 22; 106(2):338-350.Gonzalez MB, Robker RL, Rose RD
  • The prevalence of obesity in adults worldwide, and specifically in women of reproductive age, is concerning given the risks to fertility posed by the increased risk of type 2 diabetes, metabolic syndrome, and other noncommunicable diseases. Obesity has a multi-systemic impact in female physiology that is characterized by the presence of oxidative stress, lipotoxicity, and the activation of pro-in…
  • Cardiometabolic consequences of maternal hyperandrogenemia in male offspring. [Journal Article]
    Physiol Rep. 2021 07; 9(14):e14941.Zuchowski Y, Dalmasso C, … Reckelhoff JF
  • Polycystic ovary syndrome (PCOS) in women is characterized by hyperandrogenemia, obesity, and oligo- or anovulation. In addition, women with PCOS are often obese, with insulin resistance, hyperlipidemia, and elevated blood pressure. The cardiometabolic consequences for the male offspring of maternal hyperandrogenemia are unclear. The present studies tested the hypothesis that male offspring of a …
  • Diagnosis and Management of Infertility: A Review. [Review]
    JAMA. 2021 Jul 06; 326(1):65-76.Carson SA, Kallen AN
  • CONCLUSIONS: Approximately 1 in 8 women aged 15 to 49 years receive infertility services. Although success rates vary by age and diagnosis, accurate diagnosis and effective therapy along with shared decision-making can facilitate achievement of fertility goals in many couples treated for infertility.
  • Chronic Low Grade Inflammation in Pathogenesis of PCOS. [Review]
    Int J Mol Sci. 2021 Apr 06; 22(7)Rudnicka E, Suchta K, … Meczekalski B
  • Polycystic ovary syndrome (PCOS) is a one of the most common endocrine disorders, with a prevalence rate of 5-10% in reproductive aged women. It's characterized by (1) chronic anovulation, (2) biochemical and/or clinical hyperandrogenism, and (3) polycystic ovarian morphology. PCOS has significant clinical implications and can lead to health problems related to the accumulation of adipose tissue,…
  • The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome. [Journal Article]
    Nat Commun. 2021 02 16; 12(1):1064.Bourgneuf C, Bailbé D, … Racine C
  • Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulat…
  • The causes of infertility in women presenting to gynaecology clinics in Harare, Zimbabwe; a cross sectional study. [Journal Article]
    Fertil Res Pract. 2021 Jan 05; 7(1):1.Madziyire MG, Magwali TL, … Mhlanga T
  • CONCLUSIONS: Most women present when chances of natural spontaneous conception are considerably reduced. This study shows an almost equal contribution between tubal blockage, male factor and unexplained infertility. Almost half of the causes are female factors constituted by tubal blockage, anovulation and a mixture of the two. Improved access to ART will result in improved pregnancy rates. Programs should target comprehensive assessment of both partners and offer ART.
  • Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. [Meta-Analysis]
    Cochrane Database Syst Rev. 2020 12 21; 12:CD006105.Tso LO, Costello MF, … Macedo CR
  • CONCLUSIONS: This updated review on metformin versus placebo/no treatment before or during IVF/ICSI treatment in women with PCOS found no conclusive evidence that metformin improves live birth rates. In a long GnRH-agonist protocol, we are uncertain whether metformin improves live birth rates, but metformin may increase the clinical pregnancy rate. In a short GnRH-antagonist protocol, metformin may reduce live birth rates, although we are uncertain about the effect of metformin on clinical pregnancy rate. Metformin may reduce the incidence of OHSS but may result in a higher incidence of side effects. We are uncertain of the effect of metformin on miscarriage rate per woman.
  • Prevalence and risk factors related to anovular phenotypes in dairy cows. [Journal Article]
    J Dairy Sci. 2021 Feb; 104(2):2369-2383.Monteiro PLJ, Gonzales B, … Sartori R
  • The objective of the current study was to evaluate the relationship of body condition score (BCS) at 35 d in milk (DIM), milk production, diseases, and duration of the dry period with prevalence of anovulation at 49 DIM and then, specifically, with the prevalence of each anovular phenotype. We hypothesized that anovular follicular phenotypes, classified based on maximal size of the anovular folli…
  • The Role of Oocyte Quality in Explaining "Unexplained" Infertility. [Review]
    Semin Reprod Med. 2020 01; 38(1):21-28.Homer HA
  • Infertility is described as unexplained when pregnancy does not occur despite ovulation, patent Fallopian tubes, and normal semen parameters. Oocyte developmental competence (or quality) is rate-limiting for pregnancy success as oocytes provide virtually all the cellular building blocks including mitochondria required during embryogenesis. However, available tests estimate oocyte numbers (anti-Mü…
  • How and Why to Define Unexplained Infertility? [Journal Article]
    Semin Reprod Med. 2020 01; 38(1):55-60.Abdallah KS, Hunt S, … Youssef MA
  • Unexplained infertility represents up to 30% of all cases of infertility. It is a diagnosis of exclusion, where no cause for infertility may be identified in the investigation of the couple, be it anovulation, fallopian tube blockage, or severe male factor. Unexplained infertility therefore cannot be considered a diagnosis to which a specific treatment is directed, rather that it indicates a fail…
  • A Clinician's Guide to Functional Hypothalamic Amenorrhea. [Journal Article]
    Clin Obstet Gynecol. 2020 12; 63(4):706-719.Ruiz-Zambrana A, Berga SL
  • Patients and clinicians alike want to know if stress causes infertility. Stress could impair with reproductive function by a variety of mechanisms, including compromise of ovarian function, spermatogenesis, fertilization, endometrial development, implantation, and placentation. Herein we focus on the pathogenesis and treatment of stress-induced anovulation, which is often termed functional hypoth…
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