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Unbound Medicine.
(Prostate cancer)
203,320 results
  • Prostate Cancer Associated with Minimal Change Disease: A Case Report. [Case Reports]
    Glomerular Dis. 2022 Jul; 2(3):145-150.Nakano Y, Yoshida M, … Fujisawa H
  • Minimal change disease (MCD), a common cause of primary nephrotic syndrome that accounts for 10%-15% of all primary nephrotic syndrome cases in adults, is frequently associated with malignant lymphoma. However, studies on MCD associated with prostate cancer are scarce.
  • Macrophages promote anti-androgen resistance in prostate cancer bone disease. [Journal Article]
    J Exp Med. 2023 Apr 03; 220(4)Li XF, Selli C, … Qian BZ
  • Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of disease mechanisms, the specific contribution of the metastatic microenvironment to ADT resistance remains largely unknown. The current study identified that the macrophage is the major microenvironmental component o…
  • Impact of previous depression on the risk of suicide among prostate cancer patients. [Journal Article]
    Acta Oncol. 2023 Feb 07 [Online ahead of print]Friberg AS, Carlsson SV, … Johansen C
  • CONCLUSIONS: The absolute risk of suicide is low following a prostate cancer diagnosis. Time since diagnosis and a history of depression was associated with the highest risk of suicide. Healthcare professionals should be aware of an increased risk of suicide among men with previous depression, especially in the immediate aftermath of the diagnosis.
  • DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations. [Journal Article]
    Cancer Res. 2023 Feb 07 [Online ahead of print]Gallon J, Rodriguez-Calero A, … Piscuoglio S
  • Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct DNA methylation profiles have been shown to be associated with the mutually exclusive SPOP mutant or TMPRSS2-ERG fusion genetic backgrounds. Using a c…
  • Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy. [Review]
    Med Mol Morphol. 2023 Feb 07 [Online ahead of print]Kamiya S, Nakamori Y, … Osanai M
  • In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast, colorectal and prostate tumors. Given the pleiotropic cellular activity of vitamin D, its deficiency impairs its physiological function in target cells and results in various pathologies including cancer. In addition, accumulated data have shown t…
  • Time series radiomics for the prediction of prostate cancer progression in patients on active surveillance. [Journal Article]
    Eur Radiol. 2023 Feb 07 [Online ahead of print]Sushentsev N, Rundo L, … Blyuss O
  • Serial MRI is an essential assessment tool in prostate cancer (PCa) patients enrolled on active surveillance (AS). However, it has only moderate sensitivity for predicting histopathological tumour progression at follow-up, which is in part due to the subjective nature of its clinical reporting and variation among centres and readers. In this study, we used a long short-term memory (LSTM) recurren…
  • Antibody Immobilization on Sulfated Cellulose Nanocrystals. [Journal Article]
    Biomacromolecules. 2023 Feb 07 [Online ahead of print]Nori UM, Gomez-Maldonado D, … Davis VA
  • Exploiting cellulose nanocrystals' high aspect ratio and tailorable surface for immunological biosensors has been hindered by the relatively limited research on using commonly available sulfated cellulose nanocrystals (CNCs) for antibody immobilization and by the low hydrolytic stability of dried assemblies produced from sulfated CNCs. Herein, we report a reaction scheme that enables both hydroly…
  • Research Progress on Gene Synthesis and Anticancer and Lipid-lowering Mechanism of Monacolin K. [Journal Article]
    Anticancer Agents Med Chem. 2023 Feb 07 [Online ahead of print]Sun QW, Hong HS
  • Monacolin K (MK), also known as lovastatin (LOV), is a secondary metabolite synthesized by Monascus in the later stage of fermentation and is the main component of functional red yeast rice (RYR). The structure of MK is similar to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), and it can competitively bind to 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), thus reducing the level of bl…
  • Role, race, and place: Prostate cancer disparities in Patients' and Partners' health outcomes and psychosocial factors. [Journal Article]
    Cancer Med. 2023 Feb 07 [Online ahead of print]Song L, Keyserling TC, … Rini C
  • CONCLUSIONS: Our findings underscore the need to consider social determinants of health at multiple levels when investigating PCa disparities. Considering neighborhood-level socioeconomic factors, in addition to race and role, improves our understanding of the PCa disparities in QOL, symptoms, and psychosocial factors among patients and partners. Targeted multilevel supportive care interventions should tailor to the needs of racially diverse PCa patients and partners residing in deprived neighborhoods are needed.
  • Deepfake Histologic Images for Enhancing Digital Pathology. [Journal Article]
    Lab Invest. 2023 Jan; 103(1):100006.Falahkheirkhah K, Tiwari S, … Bhargava R
  • A pathologist's optical microscopic examination of thinly cut, stained tissue on glass slides prepared from a formalin-fixed paraffin-embedded tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of pathologists is dependent on their direct experience with common and rarer variant morphologies. Recently, deep learning approaches have been …
  • CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity. [Journal Article]
    Heliyon. 2023 Jan; 9(1):e13044.Ffrench B, Kashdan E, … O'Leary JJ
  • Metastatic progression and tumor evolution complicates the clinical management of cancer patients. Circulating tumor cell (CTC) characterization is a growing discipline that aims to elucidate tumor metastasis and evolution processes. CTCs offer the clinical potential to monitor cancer patients for therapy response, disease relapse, and screen 'at risk' groups for the onset of malignancy. However,…
  • Osteolytic lesions: Multiple myeloma or prostate cancer? [Case Reports]
    Radiol Case Rep. 2023 Apr; 18(4):1485-1489.Devaraj A, Al-Sader H
  • Multiple myeloma is a cancer which is characterized by proliferation of malignant B-cells and plasma cell infiltration of bone marrow. Lytic lesions are one of its hallmarks, on radiological assessment. We report 2 cases who presented within 1 year to our hospital with bony lytic lesions on CT scan. They were investigated for multiple myeloma; however, there were no further features to suggest th…
  • Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers. [Review]
    Chem Biol Drug Des. 2023 Feb 06 [Online ahead of print]Pandey P, Khan F, Upadhyay TK
  • Cancer is a complicated malignancy controlled by numerous intrinsic and extrinsic pathways. There has been a significant increase in interest in recent years in the elucidation of cancer treatments based on natural extracts that have fewer side effects. Numerous natural product-derived chemicals have been investigated for their anticancer effects in the search for an efficient chemotherapeutic me…
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