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49,310 results
  • Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab [Journal Article]
    J Drugs Dermatol 2019; 18(10):1047Milani-Nejad N, Kaffenberger J
  • To the Editor: Acrodermatitis continua of Hallopeau (ACH) is a relatively rare chronic disorder with clinical findings of pustules and erythematous plaques on the digits.1 Although it is a variant of pustular psoriasis, it can be resistant to multiple lines of therapy. We describe for the first time a patient with recalcitrant ACH successfully treated with brodalumab, an interleukin-17 receptor A…
  • Anti IL-17 in psoriasis. [Journal Article]
    Expert Rev Clin Immunol 2019Ly K, Smith MP, … Bhutani T
  • Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. Its pathogenesis is likely multifactorial, however, the interleukin-23/T helper 17 pathway has been identified as a critical axis in its pathogenesis. Interleukin-17A is the primary effector of this pathway and overexpression of IL-17A results in epidermal hyperplasia and an overly robust infl…
  • Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases. [Journal Article]
    J Med Chem 2019Chang Y, Xu S, Ding K
  • TYK2 is an emerging drug target for various human autoimmune diseases. However, discovery of selective TYK2 inhibitor over other JAK family members (i.e., JAK1, 2, 3) by targeting the catalytically active site (Janus Homologue 1 (JH1) domain) is challenging. This Viewpoint discusses the discovery of a series of N-methyl pyridazine-3-carboxamides as novel selective pseudokinase (JH2) domain binder…
  • IL-36β Promotes Inflammatory Activity and Inhibits Differentiation of Keratinocytes In Vitro. [Journal Article]
    Chin Med Sci J 2019; 34(3):199-204Wang WM, Wu C, … Jin HZ
  • Objective Psoriasis is an immune-mediated inflammatory disease. Despite advances in the study of its pathogenesis, the exact development mechanism of psoriasis remains to be fully elucidated. Hyperproliferative epidermis plays a crucial role in psoriasis. This study aimed to investigate the effects of interleukin-36β (IL-36β) on keratinocyte dysfunction in vitro. Methods Human keratinocyte cell l…
  • Nanodermatology-Based Solutions for Psoriasis: State-of-the Art and Future Prospects. [Review]
    Dermatol Ther 2019; :e13113Damiani G, Pacifico A, … Bragazzi NL
  • Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine. Nanodermatology deals with i) skin biology, anatomy and physiology at the nanoscale ("skin nanobiology"), ii) diagnosis performed by means of novel diagnostic devices, ass…
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