- Recent developments in minimally invasive surgery for biopsy of small pulmonary nodules. [Review]
- JTJ Thorac Dis 2018; 10(Suppl 7):S905-S908
- Following the development of radiological technology, there has been an increase in the number of pulmonary nodules found. The management of pulmonary nodules represents a specific challenge to thora...
Following the development of radiological technology, there has been an increase in the number of pulmonary nodules found. The management of pulmonary nodules represents a specific challenge to thoracic surgeons. Pulmonary nodules are small, focal, rounded radiographic opacities that may be solitary or multiple. The definite histopathologic diagnosis is crucial in determining management ranging from interval imaging to surgical resection. The choice of a particular biopsy technique depends on the risks/benefits of the procedure, the diagnostic yield, and local expertise. Surgical lung biopsy has been reported as an accurate approach when less-invasive diagnostic methods have been unsuccessful. During the last decade, there have been huge developments of new minimally invasive techniques in thoracic surgery. In the present study, we will review both surgical and anesthetic techniques in surgical lung biopsy.
- Management pathways for solitary pulmonary nodules. [Review]
- JTJ Thorac Dis 2018; 10(Suppl 7):S860-S866
- Pulmonary nodules are often detected during the clinical course of several diseases or through routine screening. Various guidelines have proposed management algorithms for suspicious solitary nodule...
Pulmonary nodules are often detected during the clinical course of several diseases or through routine screening. Various guidelines have proposed management algorithms for suspicious solitary nodules in lung cancer. Generally, solitary pulmonary nodules are managed according to nodule appearance and risk of lung cancer using low-dose, thin section computed tomography (CT). Liquid biopsy is promising for diagnosis, therapeutic-monitoring and follow-up in lung cancer; however, diagnosis and management pathways based on genetic examination alone have not been established. Management of solitary pulmonary nodules should be carried out by a multidisciplinary team and tissue biopsy is necessary for the diagnosis of lung cancer. Genetic analysis via liquid biopsy is warranted in addition to more established techniques in pulmonary nodule management.
- Comprehensive targeted super-deep next generation sequencing enhances differential diagnosis of solitary pulmonary nodules. [Journal Article]
- JTJ Thorac Dis 2018; 10(Suppl 7):S820-S829
- CONCLUSIONS: These results showed that lung cancer gene-targeted deep capture sequencing is not efficient enough to achieve ideal sensitivity by simply increasing the sequencing depth of ctDNA from early candidates. The sequencing could not be evaluated hotspot mutations in the early tumour stage. Nevertheless, a larger cohort is required to optimize this model, and more techniques may be incorporated to benefit the SPN high-risk population.
- Malignant solitary pulmonary nodules: assessment of mass growth rate and doubling time at follow-up CT. [Journal Article]
- JTJ Thorac Dis 2018; 10(Suppl 7):S797-S806
- CONCLUSIONS: Mass measurements are an objective and accurate indicator in SPN assessment. During a 2-year follow-up, the mean growth rates of the diameter, volume, and mass of pGGNs, pSNs, and SNs differed at different time points, the greatest difference was observed in mean MGR. Mean MDT of malignant SPNs is less than the mean VDT.
- Diagnostic performance of fluorine-18 fluorodeoxyglucose positron emission tomography in the management of solitary pulmonary nodule: a meta-analysis. [Journal Article]
- JTJ Thorac Dis 2018; 10(Suppl 7):S779-S789
- CONCLUSIONS: The results suggest 18F-FDG-PET/CT has good diagnostic accuracy in SPNs evaluation; but, it should not be considered as a discriminatory test rather than a method to be included in a clinical and diagnostic pathway.
- [Atypical Pulmonary Carcinoid Tumor with Elevated Serum ProGRP;Report of a Case]. [Journal Article]
- KGKyobu Geka 2018; 71(3):236-239
- We report a case of an atypical pulmonary carcinoid with high serum ProGRP. A 78-year-old man was found to have an abnormal shadow by a chest X-ray. Chest computed tomography (CT) revealed a solitary...
We report a case of an atypical pulmonary carcinoid with high serum ProGRP. A 78-year-old man was found to have an abnormal shadow by a chest X-ray. Chest computed tomography (CT) revealed a solitary pulmonary nodule in the right middle lobe, which was homogeneous, well demarcated, and round. The level of serum ProGRP was elevated to 104.6 pg/ml (normal<81 pg/ml). The nodule was suspected to be a pulmonary carcinoid tumor, and a right middle lobectomy with mediastinal lymph node dissection was performed. Histopathological diagnosis was an atypical pulmonary carcinoid. Pro-GRP decreased to be normal level 5 month after operation.
- Performance of FDG-PET/CT in solitary pulmonary nodule based on pre-test likelihood of malignancy: results from the ITALIAN retrospective multicenter trial. [Journal Article]
- EJEur J Nucl Med Mol Imaging 2018 May 07
- CONCLUSIONS: Visual FDG-PET/CT has an acceptable performance in patients with SPN, but accuracy improves when SUVratios are considered, particularly in patients with intermediate and high risk of malignancy.
- Risk-related 18F-FDG PET/CT and new diagnostic strategies in patients with solitary pulmonary nodule: the ITALIAN multicenter trial. [Journal Article]
- EJEur J Nucl Med Mol Imaging 2018 May 05
- CONCLUSIONS: Pre-test probability of malignancy can guide the diagnostic strategy of 18FDG-PET/CT in patients with SPN. In subjects with low-intermediate pretest probability s-PET/CT imaging might be planned in advance, while in those at high risk and with thoracic lymph node involvement a wb-PET/CT is necessary.
- Placental transmogrification of the lung presenting as a peripheral solitary nodule in a male with the history of trauma: A case report. [Case Reports]
- MMedicine (Baltimore) 2018; 97(18):e0661
- CONCLUSIONS: The patient had a history of traffic accident half a year before the nodule was detected. This prompts placental transmogrification of the lung may at least partially represent a acquired malformation. The present case aims to raise a new suggestion for its possible nature. In our opinion, PT may simply represent a benign morphologic change rather than an independent disease. It may be encountered in both congenital and secondary lesions.
New Search Next
- Predictive value of dual-time 18F-FDG PET/CT to distinguish primary lung and metastatic adenocarcinoma in solitary pulmonary nodule. [Journal Article]
- TTumori 2018 Apr 01; :300891618766203
- CONCLUSIONS: Dual-timepoint 18F-FDG PET/CT can be useful to distinguish primary and metastatic lung adenocarcinoma in SPN. Furthermore, it may also be useful to predict metastatic adenocarcinoma from colorectal origin.