- Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP. [Letter]
- JDJ Dermatol 2018 Sep 19
- Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as...
Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as a collaborative project between the Japanese Dermatological Association and the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labour, and Welfare Research Project on Overcoming Intractable Diseases. The aim of the guidelines was to provide current information to aid in the treatment of patients with GPP in Japan. Its contents include the diagnostic and severity classification criteria for GPP, its pathogenesis, and recommendations for the treatment of GPP. Since there are few clinical trial data with high levels of evidence for this rare disease, recommendations by the committee are described in the present guidelines.
- Feline Pemphigus Foliaceus. [Review]
- VCVet Clin North Am Small Anim Pract 2018 Sep 15
- Feline pemphigus foliaceus is an uncommon skin disorder in cats but still the most common autoimmune skin disorder seen in this species. It is a crusting dermatosis involving the ears, head, paws, an...
Feline pemphigus foliaceus is an uncommon skin disorder in cats but still the most common autoimmune skin disorder seen in this species. It is a crusting dermatosis involving the ears, head, paws, and ungual folds primarily. Although cytology is helpful in supporting a diagnosis, biopsy of pustules or crusts for histopathology is required for a definitive diagnosis. Therapy has evolved over the years as we have learned more about the different ways cats respond to drugs and as new drugs became available. Most cats will respond to proper therapy, although it may be needed long term for control.
- Diagnostic Indicators of Rosacea and Demodicosis. [Journal Article]
- ADActa Derm Venereol 2018 Sep 18
- Papulopustular rosacea and demodicosis are characterized by non-specific symptoms, which can make clinical diagnosis difficult. This retrospective study of 844 patients assessed the diagnostic import...
Papulopustular rosacea and demodicosis are characterized by non-specific symptoms, which can make clinical diagnosis difficult. This retrospective study of 844 patients assessed the diagnostic importance of clinical signs and symptoms that are poorly recognized as being associated with these conditions. In addition to well-known signs (vascular signs (present in 80% of patients), papules (39%), pustules (22%) and ocular involvement (21%)), other signs and symptoms (discreet follicular scales (93%), scalp symptoms (pruritus, dandruff or folliculitis; 38%) and pruritus (15%)) may also suggest a diagnosis not only of demodicosis, but also of papulopustular rosacea. Facial Demodex densities (measured by 2 consecutive standardized skin biopsies) were higher when ocular or scalp involvement was present, suggesting more advanced disease, but further investigations are needed to confirm this hypothesis. Recognition of these clinical signs and symptoms should encourage dermatologists to perform a Demodex density test, thus enabling appropriate diagnosis to be made.
- Two Cases of Severe Erosive Pustular Dermatosis Mimicking Infection. [Journal Article]
- WWounds 2018; 30(8):E84-E86
- CONCLUSIONS: These cases represent the importance of considering topical steroid treatment and a diagnosis of EPDS after debridement for purulent scalp ulcers.
- Rapidly growing verrucous axillary tumors, multiple erosions, pustules, and cheilitis. [Case Reports]
- JDJ Dtsch Dermatol Ges 2018 Sep 13
- Disseminated Erythematous Papules and Pustules: A Quiz. [Journal Article]
- ADActa Derm Venereol 2018 Sep 03
- Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: A randomized, split-face, open-label, single-center study. [Journal Article]
- COCutan Ocul Toxicol 2018 Sep 03; :1-21
- CONCLUSIONS: This study demonstrated that 2% SSA has a similar efficacy with 5%BPO+0.1%ADA in mild to moderate acne treatment. This might be a useful pilot study that could be used to support further larger clinical trials.
- A Rare Dermatologic Disease in Pregnancy: Rosacea Fulminans- Case Report and Review of the Literature. [Journal Article]
- OAOpen Access Maced J Med Sci 2018 Aug 20; 6(8):1438-1441
- CONCLUSIONS: In conclusion, there is no substantial evidence as to the mechanism by which pregnancy may trigger this conditioner whether the gender of the fetus influences the development of rosacea fulminans, but is generally accepted that hormonal changes in pregnancy play an important role. The pathogenesis of rosacea fulminans remains uncertain, but it is obvious that the further basic and clinical research is required to optimise the management of this rare facial dermatosis.
- Pemphigus vegetans presenting as serpiginous oral, esophageal and genital mucosal ulcers undiagnosed for 3 years. [Case Reports]
- NJNiger J Clin Pract 2018; 21(9):1238-1241
- Pemphigus vegetans (PVeg) is a relatively milder and chronic variant of pemphigus vulgaris. It is very rare, constituting only about 3% of all cases of pemphigus. It is characterized by initial bulla...
Pemphigus vegetans (PVeg) is a relatively milder and chronic variant of pemphigus vulgaris. It is very rare, constituting only about 3% of all cases of pemphigus. It is characterized by initial bullae or pustules which may then progress to papillomatous vegetations or plaques. Usually, oral mucosal and cutaneous lesions are seen in the same patient. Very rarely, only mucosal presentation may be seen. In this report, we present a case of a 30-year-old woman with previously undiagnosed multiple, painful, chronic vegetative ulcers with "snail-track"-like appearance present for 3 years. Extensive clinical and laboratory investigations revealed the lesions to be due to PVeg. The patient responded to prednisolone and cyclophosphamide therapy with complete remission after 2 months.
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- Glucagonoma-Associated Necrolytic Migratory Erythema: The Broad Spectrum of the Clinical and Histopathological Findings and Clues to the Diagnosis. [Journal Article]
- AJAm J Dermatopathol 2018 Aug 17
- Necrolytic migratory erythema (NEM) is associated with glucagonoma, an endocrine malignancy of the pancreas. It is a rare and a likely underrecognized paraneoplastic dermatitis. A 38-year-old woman p...
Necrolytic migratory erythema (NEM) is associated with glucagonoma, an endocrine malignancy of the pancreas. It is a rare and a likely underrecognized paraneoplastic dermatitis. A 38-year-old woman presented to our clinic with a 3-year history of reocurring pruritic skin rashes with increasing intensity. The skin lesions presented with active annular borders, central scaling, and postinflammatory hyperpigmentation, but also with erosions, pustules, and crusted lesions. Multiple skin biopsies were taken. The workup of the patient revealed a tumor localized in the head of the pancreas, and glucagon serum levels were elevated. Clues to the diagnosis of NEM were the waxing and waning of serpiginous erythemas with active borders localized on extremities, intertriginous areas, and face. On histopathology, dyskeratosis in all layers of the epidermis were an early feature of NEM, and long-standing lesions typically showed psoriasiform hyperplasia with pallor and necrosis of upper epidermal layers. Clinicians and histopathologists need to be aware of the wide spectrum of skin manifestations in glucagonoma. Early diagnosis of the tumor is crucial for patients.