- Metastatic vulvovaginal Crohn disease in the setting of well-controlled intestinal disease. [Journal Article]
- CCutis 2018; 102(2):E16-E18
- The cutaneous manifestations of Crohn disease (CD) are varied and include pyoderma gangrenosum, erythema nodosum, and metastatic CD (MCD). The latter is defined as the occurrence of granulomatous les...
The cutaneous manifestations of Crohn disease (CD) are varied and include pyoderma gangrenosum, erythema nodosum, and metastatic CD (MCD). The latter is defined as the occurrence of granulomatous lesions at a skin site distant from the gastrointestinal tract. Metastatic CD involving the vulva and perineum is rare and thus often is difficult to diagnose. It may precede, coincide with, or develop after the initial diagnosis of intestinal disease. A variety of clinical presentations have been described, including widespread nonspecific pain and swelling, erythematous papules and plaques, and nonhealing ulcers. The diagnosis often is delayed because of a low index of suspicion brought about by the rarity of the disease and its diverse and confusing manifestations. A skin biopsy usually confirms the diagnosis by revealing noncaseating granulomas in the dermis. Multiple oral and parenteral therapies are available, with surgical intervention reserved for resistant cases. We present a case of vulvovaginal MCD in the setting of well-controlled intestinal disease.
- Epidemiology of pyoderma gangrenosum in Japanese patients by questionnaire survey. [Letter]
- JDJ Dermatol 2018 Sep 19
- Late-onset post-mammoplasty pyoderma gangrenosum treated with tobacco-pouch suture combined with oral corticosteroids. [Journal Article]
- GIG Ital Dermatol Venereol 2018 Sep 18
- Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature. [Review]
- PRPediatr Radiol 2018 Sep 17
- Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result o...
Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result of a mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene located on chromosome 15, which results in an abnormal overproduction of the pro-inflammatory cytokine interleukin-1β (IL-1). This syndrome clinically manifests as early onset of recurrent episodes of acute aseptic inflammation of the joints, generally occurring in the first two decades of life, followed by manifestation of characteristic skin lesions in the third decade, after an obvious decline in the joint symptoms. Although uncommon, the potential clinical implications of PAPA syndrome warrant an appropriate diagnosis in a timely fashion.
- Is PASH Syndrome a Biofilm Disease?: A Case Series and Review of the Literature. [Journal Article]
- WWounds 2018; 30(8):216-223
- CONCLUSIONS: As reported herein, based on biofilm's clinical presentation and resistance to proper wound healing, it could serve as the common denominator and may redirect clinicians' treatment pathways in the near future.
- Baseline risk assessment of patients with ulcerative colitis: does initial treatment selection influence outcomes? [Journal Article]
- EJEur J Gastroenterol Hepatol 2018 Sep 07
- CONCLUSIONS: Among other clinical parameters, discordance between baseline risk and treatment selection appears to be a significant predictor of outcomes in UC.
- Pyoderma gangrenosum triggered by switching from adalimumab to secukinumab. [Letter]
- JDJ Dermatol 2018 Sep 07
- ["Pseudo-pyoderma gangrenosum" or the temptation of pseudo-terminology]. [Letter]
- MMMed Mal Infect 2018 Aug 30
- Assessing the Severity of Pyoderma Gangrenosum - A Need for Validated Measurement Tools. [Letter]
- BJBr J Dermatol 2018 Sep 01
- Pyoderma gangrenosum (PG) is an autoinflammatory disorder characterized by chronic painful cutaneous ulcers and a high rate of association with systemic disease. PG is a rare condition with an estima...
Pyoderma gangrenosum (PG) is an autoinflammatory disorder characterized by chronic painful cutaneous ulcers and a high rate of association with systemic disease. PG is a rare condition with an estimated incidence of 3-10 cases per million populations per year. The seldom occurrence of PG contributes to the lack of clinical trials focused on this disease. Furthermore, studies of PG are complicated by the nonexistence of a standardized PG severity scale. This article is protected by copyright. All rights reserved.
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- Secukinumab for pyoderma gangrenosum: A case report. [Letter]
- MCMed Clin (Barc) 2018 Aug 22