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8,965 results
  • Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. [Review]
    Cochrane Database Syst Rev 2019; 9:CD005049Valembois L, Audureau E, … Lafuente-Lafuente C
  • CONCLUSIONS: There is high-certainty evidence of increased mortality associated with sotalol treatment, and low-certainty evidence suggesting increased mortality with quinidine, when used for maintaining sinus rhythm in people with atrial fibrillation. We found few data on mortality in people taking disopyramide, flecainide and propafenone, so it was not possible to make a reliable estimation of the mortality risk for these drugs. However, we did find moderate-certainty evidence of marked increases in proarrhythmia and adverse effects with flecainide.Overall, there is evidence showing that antiarrhythmic drugs increase adverse events, increase proarrhythmic events and some antiarrhythmics may increase mortality. Conversely, although they reduce recurrences of atrial fibrillation, there is no evidence of any benefit on other clinical outcomes, compared with placebo or no treatment.
  • Electrical storm in an acquired short QT syndrome successfully treated with quinidine. [Journal Article]
    Clin Case Rep 2019; 7(8):1617-1618Spartalis M, Livanis E, … Tsoutsinos A
  • Short QT syndrome (SQTS) is a malignant heart disorder defined by the presence of ventricular arrhythmias causing syncope and sudden cardiac arrest. The prevalence in the pediatric population is 0.05%. Quinidine is an established agent for pharmacological prophylaxis in SQTS patients, but can also terminate an electrical storm.
  • Concurrent Quinidine and Phenobarbital in the Treatment of a Patient with 2 KCNT1 Mutations. [Journal Article]
    Curr Ther Res Clin Exp 2019; 90:106-108Passey CC, Erramouspe J, … Denton DM
  • Epilepsy of infancy with migrating focal seizures is a devastating pediatric neurologic disorder that often results in treatment-resistant seizure activity and developmental delay. The condition has been associated with mutations in the KCNT1 gene that cause a gain of function in neuronal sodium-activated potassium channels. Quinidine has been shown to reverse this gain of function and has recent…
  • Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2. [Journal Article]
    Pharmacol Res Perspect 2019; 7(4):e00504Oranje P, Gouka R, … van Westen GJP
  • Selective analogs of the natural glycoside phloridzin are marketed drugs that reduce hyperglycemia in diabetes by inhibiting the active sodium glucose cotransporter SGLT2 in the kidneys. In addition, intestinal SGLT1 is now recognized as a target for glycemic control. To expand available type 2 diabetes remedies, we aimed to find novel SGLT1 inhibitors beyond the chemical space of glycosides. We …
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