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9,056 results
  • Medical Genetics Summaries: Atomoxetine Therapy and CYP2D6 Genotype [BOOK]
    . National Center for Biotechnology Information (US): Bethesda (MD)Pratt VM, McLeod HL, … Malheiro AJDean LBOOK
  • Atomoxetine (brand name Strattera) is a non-stimulant drug used in the treatment of attention-deficit hyperactivity disorder (ADHD). It is a selective noradrenaline reuptake inhibitor (SNRI) and is approved for children aged 6 and older, adolescents, and adults. Atomoxetine is part of a treatment plan for ADHD that may include other measures such as psychological, educational, and social support.…
  • Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs. [Journal Article]
    Pharmaceutics. 2020 Jun 16; 12(6)Hellinen L, Bahrpeyma S, … Urtti A
  • Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma. As melanin is present in many pigmented tissues in the human body, investigation of pigment binding is relevant in drug discovery and development. Convention…
  • StatPearls: Disopyramide [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Sundjaja Joshua H. JH Atma Jaya Catholic University Makaryus Amgad N. AN Zucker School Medicine/Hofstra/Northwell BOOK
  • In 1962, there was a need for new antiarrhythmic drugs other than quinidine and procainamide, the main available antiarrhythmic agents available at that time. From more than 500 compounds synthesized for the research program of new antiarrhythmic agents, disopyramide is the selected agent. The chemical structures of disopyramide have a resemblance to the synthetic muscarinic antagonist, lachesine…
  • Personalized medicine in genetic epilepsies - possibilities, challenges, and new frontiers. [Review]
    Neuropharmacology. 2020 Aug 01; 172:107970.Helbig I, Ellis CA
  • Identifying the optimal treatment based on specific characteristics of each patient is the main promise of precision medicine. In the field of epilepsy, the identification of more than 100 causative genes provides the enticing possibility of treatments targeted to specific disease etiologies. These conditions include classical examples, such as the use of vitamin B6 in antiquitin deficiency or th…
  • Evidence for using dextromethorphan-quinidine for the treatment of agitation in dementia. [Editorial]
    World J Psychiatry. 2020 Apr 19; 10(4):29-33.Tampi RR, Joshi P, … Tampi DJ
  • Behavioral and psychological symptoms including agitation are common in dementia, and are associated with decreased quality of life, increased risk of institutionalization, and greater patient and caregiver distress. Pharmacological agents used for management of behavioral and psychological symptoms of dementia are limited by their tolerability, prompting a need for identifying efficacious and sa…
  • Diagnostic challenges of Brugada Syndrome in pediatric patients. [Journal Article]
    J Electrocardiol. 2020 Mar 31; 60:72-76.Manzano-Cabada J, Reyes-Quintero ÁE, … Márquez MF
  • Although most cases of Brugada syndrome have been described in adults, pediatric patients with the disease have been reported since the original article from Josep and Pedro Brugada. Herein is presented the case series of Brugada syndrome in pediatric population of the National Institute of Cardiology Ignacio Chavez. One boy and two adolescent males had palpitations as clinical presentation of th…
  • Quantum Chemical Lipophilicities of Antimalarial Drugs in Relation to Terminal Half-Life. [Journal Article]
    ACS Omega. 2020 Mar 31; 5(12):6500-6515.Alia JD, Karl S, Kelly TD
  • According to the WHO, artemisinin-based combination therapies (ACTs) have been integral to the recent reduction in deaths due to Plasmodium falciparum malaria. ACT-resistant strains are an emerging problem and have evolved altered developmental stages, reducing exposure of the most susceptible stages to artemisinin drugs in popular ACTs. Lipophilicity, log Kow, is a guide in understanding and pre…
  • Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol. [Journal Article]
    Chem Biol Interact. 2020 May 01; 322:109053.Fu Y, Tian X, … Zheng J
  • Notopterol (NOT) is a major bioactive ingredient extracted from the rhizomes of either Notopterygium incisum Ting ex H. T. Chang or N. forbesii Boiss (Qianghuo in Chinese), a botanical drug that was adopted as a traditional Chinese medicine. NOT is suggested to show analgesic and anti-inflammatory effects in clinical practice. The inhibitory effects of NOT on human cytochrome P450 enzymes were in…
  • Post-artemisinin delayed hemolysis after oral therapy for P. falciparum infection. [Case Reports]
    IDCases. 2020; 20:e00741.Conlon CC, Stein A, … Schofield C
  • A documented side-effect of artemisinin therapy is post-artemisinin delayed hemolysis (PADH), primarily occurring after parenteral treatment for severe P. falciparum infections. PADH has been infrequently reported after oral therapy and is rarely severe enough to require hospitalization and blood transfusions. A 24 year old man was diagnosed with P. falciparum, prompting initiation of oral arteme…
  • Quinidine partially blocks mitochondrial voltage-dependent anion channel (VDAC). [Journal Article]
    Eur Biophys J. 2020 Mar; 49(2):193-205.Malik C, Ghosh S
  • Quinidine is an antiarrhythmic drug commonly used for the treatment of cardiac ailments. It affects oxidative phosphorylation, calcium uptake, and ion channels of mitochondria. We have investigated the interaction of Quinidine and mitochondrial voltage-dependent anion channel (VDAC). VDAC was purified from neuronal tissue of Wistar rats and in vitro bilayer electrophysiology experiments were perf…
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