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7,695 results
  • Validation of the Italian Young Carer of Parents Inventory-Revised (YCOPI-R). [Journal Article]
    Disabil Rehabil. 2020 Jun 22 [Online ahead of print]Landi G, Boccolini G, … Tossani E
  • Purpose: Parental illness or disability has wide ranging impacts on offspring. Due to the lack of an Italian contextually sensitive measure of youth caregiving, this study explored the factor structure, reliability, and validity of the Italian version of the Young Carer of Parents Inventory-Revised (YCOPI-R).Materials and methods: Seven hundred and seventy-four youth aged 11-24 (386 young carers…
  • Rainfall erosivity in South America: Current patterns and future perspectives. [Journal Article]
    Sci Total Environ. 2020 Jul 01; 724:138315.Riquetti NB, Mello CR, … Viola MR
  • Rainfall erosivity is the driving factor for soil erosion and can be potentially affected by climate change, impacting agriculture and the environment. In this study, we sought to project the impact of climate change on the long-term average annual rainfall erosivity (R-factor) and mean annual precipitation in South America. The CanESM2, HadGEM2-ES, and MIROC5 global circulation models (GCMs) and…
  • A novel reproductive strategy in an Early Devonian plant. [Letter]
    Curr Biol. 2020 May 04; 30(9):R388-R389.Bonacorsi NK, Gensel PG, … Leslie AB
  • Bonacorsi et al. describe a new fossil from the Early Devonian that provides the earliest clear evidence for more advanced reproductive biology in land plants. The plant produced multiple spore size classes, which is an essential innovation necessary for all advanced plant reproductive strategies, including seeds and flowers.
  • Hydrothermal Synthesis and Crystal Structure of a Mixed-Valence Bismuthate, Na3Bi3O8. [Journal Article]
    Inorg Chem. 2020 Apr 06; 59(7):4950-4960.Saiduzzaman M, Akutsu S, … Kusano Y
  • Four types of bismuth oxides, Na3Bi3O8, NaBiO3, α-Bi2O3, and ε-Bi2O3, were obtained by hydrothermal reactions using NaBiO3·nH2O in NaOH solution. The crystal structure of a new phase (Na3 Bi3+)Bi25+O8 ((Na0.75Bi0.25)2BiO4) was determined by using single crystal X-ray diffraction data, and this compound was found to show a Na2MnCl4-related structure with a monoclinic system (space group, Pm) with …
  • The atomic structure of the Bergman-type icosahedral quasicrystal based on the Ammann-Kramer-Neri tiling. [Journal Article]
    Acta Crystallogr A Found Adv. 2020 Mar 01; 76(Pt 2):180-196.Buganski I, Wolny J, Takakura H
  • In this study, the atomic structure of the ternary icosahedral ZnMgTm quasicrystal (QC) is investigated by means of single-crystal X-ray diffraction. The structure is found to be a member of the Bergman QC family, frequently found in Zn-Mg-rare-earth systems. The ab initio structure solution was obtained by the use of the Superflip software. The infinite structure model was founded on the atomic …
  • Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines. [Journal Article]
    PLoS Comput Biol. 2020 Mar; 16(3):e1007147.Raimúndez E, Keller S, … Hasenauer J
  • Targeted cancer therapies are powerful alternatives to chemotherapies or can be used complementary to these. Yet, the response to targeted treatments depends on a variety of factors, including mutations and expression levels, and therefore their outcome is difficult to predict. Here, we develop a mechanistic model of gastric cancer to study response and resistance factors for cetuximab treatment.…
  • Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus. [Journal Article]
    Protein Sci. 2020 May; 29(5):1148-1159.Ferek JD, Thoden JB, Holden HM
  • The exciting discovery of the giant DNA Mimivirus in 2003 challenged the conventional description of viruses in a radical way, and since then, dozens of additional giant viruses have been identified. It has now been demonstrated that the Mimivirus genome encodes for the two enzymes required for the production of the unusual sugar 4-amino-4,6-dideoxy-d-glucose, namely a 4,6-dehydratase and an amin…
  • Engineering a CRISPR Interference System To Repress a Class 1 Integron in Escherichia coli. [Journal Article]
    Antimicrob Agents Chemother. 2020 02 21; 64(3)Li Q, Zhao P, … Tian P
  • Microbial multidrug resistance (MDR) poses a huge threat to human health. Bacterial acquisition of MDR relies primarily on class 1 integron-involved horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs). To date, no strategies other than the use of antibiotics can efficiently cope with MDR. Here, we report that an engineered CRISPR interference (CRISPRi) system can markedly reduce …
  • Comparison of automated crystallographic model-building pipelines. [Journal Article]
    Acta Crystallogr D Struct Biol. 2019 Dec 01; 75(Pt 12):1119-1128.Alharbi E, Bond PS, … Cowtan K
  • A comparison of four protein model-building pipelines (ARP/wARP, Buccaneer, PHENIX AutoBuild and SHELXE) was performed using data sets from 202 experimentally phased cases, both with the data as observed and truncated to simulate lower resolutions. All pipelines were run using default parameters. Additionally, an ARP/wARP run was completed using models from Buccaneer. All pipelines achieved nearl…
  • Exploring the relationship between resilience and practice education placement success in occupational therapy students. [Journal Article]
    Aust Occup Ther J. 2020 02; 67(1):49-61.Brown T, Yu ML, … Etherington J
  • CONCLUSIONS: The resilience factors identified as being significant predictors of practice education performance outcomes in occupational therapy students represent notable findings. They suggest that students' capabilities in managing their stress levels, finding meaning in their chosen profession, and engaging self-care daily activities outside of the work environment that are meaningful, authentic and fit with one's personal values and beliefs can act as buffers against the challenges experienced by students who are completing practice education placements. The findings will assist academic and practice educators in identifying and targeting vulnerable students and strengthening resilience strategies through proactive pre-practice placement initiatives. Qualitative studies are recommended to further explore the relationship between resilience and practice education performance in occupational therapy students.
  • Atomistic Modeling of Scattering Curves for Human IgG1/4 Reveals New Structure-Function Insights. [Journal Article]
    Biophys J. 2019 12 03; 117(11):2101-2119.Wright DW, Elliston ELK, … Perkins SJ
  • Small angle x-ray and neutron scattering are techniques that give solution structures for large macromolecules. The creation of physically realistic atomistic models from known high-resolution structures to determine joint x-ray and neutron scattering best-fit structures offers a, to our knowledge, new method that significantly enhances the utility of scattering. To validate this approach, we det…
  • Spectrophotometric Assays to Quantify the Activity of T4SS ATPases. [Journal Article]
    Methods Mol Biol. 2020; 2075:135-143.Cabezón E, Arechaga I
  • Biogenesis of T4SS apparatus and substrate transport require energy. Conjugative T4SS have three ATPases that enable DNA processing and transport of the nucleoprotein complex to the recipient cell. In the conjugative plasmid R388, these ATPases are named TrwB, TrwK, and TrwD. Here, three different spectrophotometric assays to measure the enzymatic properties of these ATPases are described. The ch…
  • The structure of bovine β-lactoglobulin in crystals grown at pH 3.8 exhibiting novel threefold twinning. [Journal Article]
    Acta Crystallogr F Struct Biol Commun. 2019 Oct 01; 75(Pt 10):640-645.Yeates TO, McPherson A
  • Bovine β-lactoglobulin was crystallized from 3 M NaCl buffered at pH 3.8 with sodium citrate as thick hexagonal prisms of greater than 1 mm in edge length. Analyses of the X-ray diffraction intensities using three different current algorithms were unanimous in specifying the space group to be P6322, with unit-cell dimensions a = b = 75.47, c = 140.79 Å. No progress could be made, however, towards…
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