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78,240 results
  • Utility of Regional Anesthesia in Extremity Reconstruction. [Journal Article]
    J Reconstr Microsurg 2019Weisberger JS, Oleck NC, … Lee ES
  • CONCLUSIONS:  RA may be a safe, reasonable alternative to general anesthesia in extremity reconstruction without increase in postoperative complications. Additionally, RA use is associated with a significant reduction in operative time, potentially leading to shorter and safer procedures without compromising outcomes.
  • An overview of activity-based probes for glycosidases. [Review]
    Curr Opin Chem Biol 2019; 53:25-36Wu L, Armstrong Z, … Davies GJ
  • As the scope of modern genomics technologies increases, so does the need for informative chemical tools to study functional biology. Activity-based probes (ABPs) provide a powerful suite of reagents to probe the biochemistry of living organisms. These probes, featuring a specificity motif, a reactive chemical group and a reporter tag, are opening-up large swathes of protein chemistry to investiga…
  • Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases. [Review]
    Pharmacol Ther 2019; :107400Isoherranen N, Zhong G
  • The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA) metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 family enzymes, CYP26A1, CYP26B1 and CYP26C1 have all been shown to metabolize all-trans-retinoic acid (atRA) as well as 9-cisRA and 13-cisRA isomers and primary metabolites 4-OH-RA and 4-oxo-RA with high efficiency. While no crystal struc…
  • Residues of xenobiotics in the environment and phytotoxic activity in Armenia. [Journal Article]
    J Environ Sci Health A Tox Hazard Subst Environ Eng 2019; :1-8Tadevosyan NS, Poghosyan SB, … Tadevosyan AE
  • The article presents the results of a dynamic study (spring, summer, and fall) of the residues of certain xenobiotics such as organochlorine pesticides (OCPs), synthetic surfactants (SSs) in surface water, soil, sludge, snow and phytotoxic activity in Ararat and Lori marzes of Armenia (2016-2017). A comparative analysis of the environmental status showed that all pollutants studied such as γ-hexa…
  • What Does the Future Hold for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis? [Journal Article]
    Curr Vasc Pharmacol 2019; 17(5):425-428Doumas M, Imprialos K, … Athyros VG
  • Non-Alcoholic Fatty Liver Disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the liver tissue), in the absence of alcohol abuse or other chronic liver diseases. Its prevalence is increasing because of obesity, metabolic syndrome or Type 2 Diabetes Mellitus (T2DM). NAFLD can cause liver inflammation and progress to Non-Alcoholic Steatohepatitis (NASH), …
  • Types of pain and their psychosocial impact in women with rheumatoid arthritis. [Review]
    Womens Midlife Health 2019; 5:3Chancay MG, Guendsechadze SN, Blanco I
  • Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease predominantly affecting middle-aged women. Very commonly, pain is a manifestation of active disease and because untreated RA can result in joint deformities, the current evaluation of pain has largely focused on inflammation. In addition, treatment has centered on the premise of reducing disease activity with the hopes of hal…
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