- Effect of rapid maxillary expansion on the morphology of spheno-occipital synchondrosis in rats : A micro-CT study. [Journal Article]J Orofac Orthop 2019JO
- CONCLUSIONS: Early SOS widening could be identified in the lowest part before median palatal suture opening. Similarly, narrowing of the SOS at its top was observed before the most significant median palatal suture expansion. Thus it can be hypothesized that changes within the SOS complex result from the transmission of the orthopaedic forces rather than from a displacement of the maxillary halves.
- A Comparative Study of Localized Corrosion and Stress Corrosion Cracking of 13Cr Martensitic Stainless Steel Using Acoustic Emission and X-ray Computed Tomography. [Journal Article]Materials (Basel) 2019; 12(16)M
- An accurate evaluation of stress corrosion cracking (SCC) in 13Cr martensitic stainless steel (MSS) is still missing due to the lack of an in-situ insight into the process evolution and full characterization of the corrosion morphology. In this work, two main regimes involved in the SCC progression, including localized corrosion and cracking, were comparatively studied using in-situ acoustic emis…
An accurate evaluation of stress corrosion cracking (SCC) in 13Cr martensitic stainless steel (MSS) is still missing due to the lack of an in-situ insight into the process evolution and full characterization of the corrosion morphology. In this work, two main regimes involved in the SCC progression, including localized corrosion and cracking, were comparatively studied using in-situ acoustic emission (AE) monitoring and three-dimensional (3D) X-ray computed tomography (XCT) scanning. The stress corrosion tests were conducted with u-bent smooth specimens subjected to a single droplet of 1 μL 1% neutral NaCl solution. Localized corrosion and cracking evolution were controlled in tempered and quenched steel specimens, respectively. From XCT scanning, localized corrosion was featured by an irregular corrosion pit with deposited corrosion products containing cracks. The single dominant SCC crack was observed to initiate from corrosion pit and propagate with a 3D tortuous and discontinuous morphology. AE signals were detected in both cases. Correlated with in-situ observations and clustering analysis, source identification of AE signals was proposed. AE signals during localized corrosion were assessed to be mainly from cracking within the deposited corrosion products. Comparatively, hydrogen-bubble evolution, plastic deformation, and crack-branches coalescence were proposed as the AE sources of cracking evolution.
- Accuracy, discriminative properties and reliability of a human ESC-based in vitro toxicity assay to distinguish teratogens responsible for neural tube defects. [Journal Article]Arch Toxicol 2019AT
- The poor correlation of developmental toxicity studies in animals with human outcome data has emphasized the need for complementary assays based on human cells and tissues. As neural tube defects represent an important proportion of congenital malformations, we evaluated here the accuracy of a human embryonic stem cell (hESC)-based assay to predict chemically induced disruption of neural tube for…
The poor correlation of developmental toxicity studies in animals with human outcome data has emphasized the need for complementary assays based on human cells and tissues. As neural tube defects represent an important proportion of congenital malformations, we evaluated here the accuracy of a human embryonic stem cell (hESC)-based assay to predict chemically induced disruption of neural tube formation. As teratogenic compounds, we used cyclopamine (CPA), valproic acid (VPA), ochratoxin A (OTA) and mycophenolic acid (MMF), all suspected or known inducers of human neural tube defects, as well as theophylline and saccharin as negative control compounds. We analyzed their effects on the ability of hES cells to give rise to neural precursors (expressing specific marker Nestin), to form neural tube-like structures (rosettes), and to express specific markers (Sox1, Otx2, Lix1, EvI1, Rspo3) during rosette formation. The results showed that various effects of the selected compounds on early neural development could be specifically revealed in vitro through related alterations of neurogenic differentiation of hESC. Furthermore, it was possible to discriminate toxicants acting at different time points during embryonic development and, therefore, responsible for distinct adverse effects on neural tube formation. By comparing four different hESC lines, we observed a significant (up to fivefold) variability of the line-dependent response to toxicants. We highlight at least two sources of variability: one related to the heterogeneity of hESC lines in culture (stemness/commitment profiles); the second to possible genetically determined differences in individual sensitivity to teratogens.
- A 3-D evaluation of transverse dentoalveolar changes and maxillary first molar root length after rapid or slow maxillary expansion in children. [Journal Article]Dental Press J Orthod 2019; 24(3):79-87DP
- CONCLUSIONS: Maxillary expansion (RME and SME) does not interrupt root formation neither shows first molar apical root resorption in juvenile patients. Although slightly larger in the RME group than SME group, both activation protocols showed similar buccal bone thickness and lingual bone thickness changes, without significant difference; and RME presented similar buccal cortical bone changes to SME.
- The freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb possess hypoglycemic, hypolipidemic and hypoinsulinemic on type 2 diabetes rat model. [Journal Article]J Ethnopharmacol 2019; 244:112077JE
- CONCLUSIONS: The freeze dried extracts of Rotheca myricoides possessed significant antihyperglycemic and antidyslidemic effects. In addition it lowered serum uric levels, as well as hepatic triglycerides and hepatic weight. These results appear to validate the traditional use of this plant species in the management of diabetes mellitus.
- Alveolar restoration following rapid maxillary expansion with and without corticotomy: A microcomputed tomography study in sheep. [Journal Article]Korean J Orthod 2019; 49(4):235-245KJ
- CONCLUSIONS: Corticotomy significantly enhanced the restoration of bone quality after the retention periods for banded teeth. This benefit might result from the increased new bone formation after corticotomy.
- Correlation between Temporomandibular Joints and Nasal Cavity Width in Growing Patients after Rapid Maxillary Expansion. [Journal Article]J Contemp Dent Pract 2019; 20(6):686-692JC
- CONCLUSIONS: A correlation between the interglenoid fossa distance and intercondylar distance was exhibited 6 months after RME. The correlation between the nasal cavity width and interglenoid fossa distance was close to significant at T2.
- Nasal soft- and hard-tissue changes following tooth-borne and hybrid surgically assisted rapid maxillary expansion: A randomized clinical cone-beam computed tomography study. [Journal Article]J Craniomaxillofac Surg 2019; 47(8):1190-1197JC
- CONCLUSIONS: The hybrid and TB devices led to similarly significant widening effects in nasal soft and hard tissues in both the short term and 6 months after SARME.
- Rapid maxillary expansion in children with nocturnal enuresis:A randomized placebo-controlled trial. [Journal Article]Angle Orthod 2019AO
- CONCLUSIONS: RME has a modest effect on children with therapy-resistant NE. The treatment outcome does not seem to be due to a placebo effect of the appliance. A wide maxillary width and large voiding volume at baseline seem to be positive predictors regarding response to treatment.
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- Rapid maxillary expansion outcomes according to midpalatal suture maturation levels. [Journal Article]Prog Orthod 2019; 20(1):27PO
- CONCLUSIONS: Non-significant changes were found between the two groups, and the null hypothesis was excepted.