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(Reissner membrane)
41 results
  • A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function. [Journal Article]
    Sci Rep 2019; 9(1):6024Lin AY, Henry S, … Ho A
  • MINT2/APBA2 is a synaptic adaptor protein involved in excitatory synaptic transmission. Several nonsynonymous coding variants in MINT2 have been identified in autism spectrum disorders (ASDs); however, these rare variants have not been examined functionally and the pathogenic mechanisms are unknown. Here, we examined the synaptic effects of rat Mint2 N723S mutation (equivalent to autism-linked hu…
  • Red blood cell simulation using a coupled shell-fluid analysis purely based on the SPH method. [Journal Article]
    Biomech Model Mechanobiol 2019; 18(2):347-359Soleimani M, Sahraee S, Wriggers P
  • In this paper, a novel 3D numerical method has been developed to simulate red blood cells (RBCs) based on the interaction between a shell-like solid structure and a fluid. RBC is assumed to be a thin shell encapsulating an internal fluid (cytoplasm) which is submerged in an external fluid (blood plasma). The approach is entirely based on the smoothed particle hydrodynamics (SPH) method for both f…
  • StatPearls: Anatomy, Head and Neck, Ear Endolymph [BOOK]
    StatPearls Publishing: Treasure Island (FL) Casale Jarett J Campbell University School of OM/WakeMed Agarwal Amit A University of Texas Southwesten BOOK
  • Endolymph, also known as Scarpa fluid, is a clear fluid that can found in the membranous labyrinth of the inner ear. It is unique in composition compared to other extracellular fluids in the body due to its high potassium ion concentration (140 mEq/L) and low sodium ion concentration (15 mEq/L). Many tissues play key roles in the production and maintenance of the ionic composition of endolymph, i…
  • α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels. [Journal Article]
    J Neurosci 2018; 38(38):8277-8294Brockhaus J, Schreitmüller M, … Missler M
  • Action potential-evoked neurotransmitter release is impaired in knock-out neurons lacking synaptic cell-adhesion molecules α-neurexins (αNrxns), the extracellularly longer variants of the three vertebrate Nrxn genes. Ca2+ influx through presynaptic high-voltage gated calcium channels like the ubiquitous P/Q-type (CaV2.1) triggers release of fusion-ready vesicles at many boutons. α2δ Auxiliary sub…
  • Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals. [Journal Article]
    J Neurosci 2015; 35(40):13629-47Neupert C, Schneider R, … Heine M
  • Synapses depend on trafficking of key membrane proteins by lateral diffusion from surface populations and by exocytosis from intracellular pools. The cell adhesion molecule neurexin (Nrxn) plays essential roles in synapses, but the dynamics and regulation of its trafficking are unknown. Here, we performed single-particle tracking and live imaging of transfected, epitope-tagged Nrxn variants in cu…
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