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(Remdesivir AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV))
2,882 results
  • Characteristics and treatment of hospitalized pregnant women with Coronavirus Disease 2019, COVID-19. [Journal Article]
    Am J Obstet Gynecol MFM. 2022 Aug 12 [Online ahead of print]Sekkarie A, Woodruff R, … Havers FP
  • CONCLUSIONS: Most hospitalized pregnant patients with symptomatic COVID-19 were unvaccinated. Hospitalized pregnant patients were less likely to receive recommended remdesivir and systemic steroids compared to similar hospitalized non-pregnant women. Our results underscore the need to identify opportunities for improving COVID-19 vaccination, implementation of treatment of pregnant women, and the inclusion of pregnant women in clinical trials.
  • Practical and Highly Efficient Synthesis of Remdesivir from GS-441524. [Journal Article]
    ACS Omega. 2022 Aug 09; 7(31):27516-27522.Hu T, Zhu F, … Aisa HA
  • A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. Employing N,N-dimethylformamide dimethyl acetal (DMF-DMA) as a protecting agent, this synthesis started from (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-furan-2-carbonitrile (GS-441524) and consisted of three reactions, including protection, pho…
  • Remdesivir-loaded bis-MPA hyperbranched dendritic nanocarriers for pulmonary delivery. [Journal Article]
    J Drug Deliv Sci Technol. 2022 Aug 10 [Online ahead of print]Halevas E, Mavroidi B, … Pelecanou M
  • Remdesivir is the only clinically available antiviral drug for the treatment of COVID-19. However, its very limited aqueous solubility confines its therapeutic activity and the development of novel inhaled nano-based drug delivery systems of remdesivir for enhanced lung tissue targeting and efficacy is internationally pursued. In this work 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) hyperbranc…
  • ATP enhances the error-prone ribonucleotide incorporation by the SARS-CoV-2 RNA polymerase. [Journal Article]
    Biochem Biophys Res Commun. 2022 Aug 02; 625:53-59.Pourfarjam Y, Ma Z, Kim IK
  • The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) has caused a global pandemic. The SARS-CoV-2 RNA genome is replicated by a conserved "core" replication-transcription complex (RTC) containing an error-prone RNA-dependent RNA polymerase holoenzyme (holo-RdRp, nsp12-nsp7-nsp8) and a RNA proofreading nuclease (nsp14-nsp10). Although structures and functions of SARS-…
  • Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review. [Review]
    BMJ Open. 2022 06 03; 12(6):e045115.Pham B, Rios P, … Tricco AC
  • CONCLUSIONS: This rapid scoping review characterised a growing body of comparative-effectiveness primary studies and evidence syntheses. The results suggest future studies should focus on children, elderly ≥65 years of age, patients with mild symptoms, outpatient treatment, multimechanism therapies, harms and active comparators. The results also suggest that future living evidence synthesis and network meta-analysis would provide additional information for decision-makers on managing COVID-19.
  • Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability. [Review]
    Biotechnol Genet Eng Rev. 2022 Aug 10 [Online ahead of print]Yerrakula G, Abraham S, … Rahman MH
  • The number of studies and reviews conducted for the Carboxylesterase gene is limited in comparison with other enzymes. Carboxylesterase (CES) gene or human carboxylesterases (hCES) is a multigene protein belonging to the α/β-hydrolase family. Over the last decade, two major carboxylesterases (CES1 and CES2), located at 16q13-q22.1 on human chromosome 16 have been extensively studied as important …
  • Promoting autophagy to mitigate coronavirus disease pathology in the elderly. [Journal Article]
    Clin Transl Discov. 2022 Jun; 2(2):e68.Lund Da Costa A, Mehta H, Mathur R
  • In this commentary, we highlight autophagy's important function, while identifying potential therapeutic targets for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the elderly. Autophagy's decline in the elderly causes increased cell senescence and a dysregulated immune system. As this demographic often faces decreased vaccine-provided immunity, coronavirus disease 2019 treatment…
  • Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [Review]
    J Heterocycl Chem. 2022 Jul 28 [Online ahead of print]Kabi AK, Pal M, … Roy M
  • The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the ongoing pandemic named COVID-19 which causes a serious emergency on public health hazards of international concern. In the face of a critical medical emergency, repositioning of drugs is one of the most authentic options to design an adequate treatment for infected patients immediately. In this strategy, Remdesivir …
  • Incidental and Asymptomatic Splenic Infarction and Infrarenal Thrombus in a COVID-19 Patient. [Case Reports]
    Cureus. 2022 Jul; 14(7):e26555.Childers J, Do TVC, … Akella R
  • The cytokine storm associated with coronavirus disease 2019 (COVID-19) triggers a hypercoagulable state leading to venous and arterial thromboembolism. Lab findings associated with this phenomenon are elevated D-dimer, fibrinogen, C-reactive protein (CRP), ferritin, and procalcitonin. We present the case of a 66-year-old male with dyslipidemia who was diagnosed with COVID-19 with worsening shortn…
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