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(Rheumatology AND Dermatomyositis)
1,252 results
  • Immune-array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity across the Myositis Spectrum. [Journal Article]
  • ARArthritis Rheumatol 2017 Jan 13
  • Rothwell S, Cooper RG, … Chinoy H
  • CONCLUSIONS: This is the largest most comprehensive genetic association study to date in IBM. The data confirm that HLA is the most strongly associated region and identifies novel amino acid associations that may explain the risk in this locus; these amino acid associations differentiate IBM from polymyositis and dermatomyositis, and may determine properties of the peptide-binding groove allowing it to preferentially bind auto-antigenic peptides. A novel suggestive association within the chr3(p21.21) locus suggests a role for CCR5. This article is protected by copyright. All rights reserved.
  • Sarcoplasmic MxA expression: A valuable marker of dermatomyositis. [Journal Article]
  • NeurNeurology 2016 Dec 30
  • Uruha A, Nishikawa A, … Nishino I
  • CONCLUSIONS: Sarcoplasmic MxA expression detected by immunohistochemistry is a more sensitive marker of DM than the conventional hallmarks, indicating its practical utility in the diagnosis of DM. It may well be included in the routine immunohistochemistry panel for myositis.
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