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(Rieder cell)
760 results
  • Next-generation computational tools for interrogating cancer immunity. [Review]
    Nat Rev Genet 2019Finotello F, Rieder D, … Trajanoski Z
  • The remarkable success of cancer therapies with immune checkpoint blockers is revolutionizing oncology and has sparked intensive basic and translational research into the mechanisms of cancer-immune cell interactions. In parallel, numerous novel cutting-edge technologies for comprehensive molecular and cellular characterization of cancer immunity have been developed, including single-cell sequenc…
  • Evaluation of ultra-low input RNA sequencing for the study of human T cell transcriptome. [Journal Article]
    Sci Rep 2019; 9(1):8445Wang J, Rieder SA, … Raja R
  • Deeper understanding of T cell biology is crucial for the development of new therapeutics. Human naïve T cells have low RNA content and their numbers can be limiting; therefore we set out to determine the parameters for robust ultra-low input RNA sequencing. We performed transcriptome profiling at different cell inputs and compared three protocols: Switching Mechanism at 5' End of RNA Template te…
  • Pathogenesis of fibrostenosing Crohn's disease. [Review]
    Transl Res 2019; 209:39-54Li J, Mao R, … Rieder F
  • Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the gastrointestinal tract. A severe complication of CD is fibrosis-associated strictures, which can cause bowel obstruction. Unfortunately, there is no specific antifibrotic therapy available. More than 80% of the patients with CD will have to undergo at least 1 surgery in their life and recurrence of strictur…
  • Diverse Genome Topologies Characterize Dosage Compensation across Species. [Review]
    Trends Genet 2019; 35(4):308-315Jordan W, Rieder LE, Larschan E
  • Dosage compensation is the process by which transcript levels of the X chromosome are equalized with those of autosomes. Although diverse mechanisms of dosage compensation have evolved across species, these mechanisms all involve distinguishing the X chromosome from autosomes. Because one chromosome is singled out from other chromosomes for precise regulation, dosage compensation serves as an imp…
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