- Intra-Articular Laser Treatment Plus Platelet Rich Plasma (PRP) Significantly Reduces Pain in Many Patients Who Had Failed Prior PRP Treatment. [Journal Article]
- MMedicines (Basel) 2019 Jul 16; 6(3)
- CONCLUSIONS: PRP with IAL allowed avoidance of surgery and good pain control at least two years post-treatment in nearly half of patients who had failed PRP treatment alone.
- Characterization of an umbilical cord blood sourced product suitable for allogeneic applications. [Journal Article]
- RMRegen Med 2019 Jul 17
- CONCLUSIONS: We identified a comprehensive panel of tests to establish the clinical efficacy and quality control attributes of a UCB-sourced allograft.
- Reconstruction of Acute Acromioclavicular (AC) Joint Dislocations with or without Tendon Graft: a Retrospective Comparative Study. [Journal Article]
- ABArch Bone Jt Surg 2019; 7(3):239-245
- CONCLUSIONS: A greater but not statistically significant rate of loss of reduction was observed in the group reconstructed with the use of a tendon graft. Further research is needed to determine whether the use of tendon graft is beneficial in the treatment of acute AC joint separations.
- Single Assessment Numeric Evaluation (SANE) is a reliable metric to measure clinically significant improvements following shoulder arthroplasty. [Journal Article]
- JSJ Shoulder Elbow Surg 2019 Jul 12
- CONCLUSIONS: The present study establishes clinically significant outcomes for SANE. Achievement of clinically significant outcomes in SANE was correlated with achieving meaningful outcomes with legacy measures of ASES and Constant scores. SANE may be used as a simple and efficient measure of patient outcome after total shoulder arthroplasty.
- Analysis of Return to Sport and Weight Training After Repair of the Pectoralis Major Tendon. [Journal Article]
- AJAm J Sports Med 2019 Jul 15; :2151-2157
- CONCLUSIONS: Patients undergoing PMT repair should expect significant functional improvements and a low complication rate. Yet, only 50% are able to return to preoperative intensity of sport, and they will also have significant reductions in their ability to weight lift.
- Impact of coxsackievirus-B4E2 combined with a single low dose of streptozotocin on pancreas of outbred mice: investigation of viral load, pathology and inflammation. [Journal Article]
- SRSci Rep 2019 Jul 12; 9(1):10080
- Coxsackieviruses B (CV-B) belong to the EV-B species. CV-B and particularly CV-B4 are thought to be involved in the development of chronic diseases like type 1 diabetes (T1D). The mechanisms of the e…
Coxsackieviruses B (CV-B) belong to the EV-B species. CV-B and particularly CV-B4 are thought to be involved in the development of chronic diseases like type 1 diabetes (T1D). The mechanisms of the enteroviral pathogenesis of T1D are not well known, yet. The in vitro studies are rich with information but in vivo infection models are needed to investigate the impact of viruses onto organs. Our objective was to study the impact of CV-B4E2 combined with a single sub-diabetogenic dose of streptozotocin (STZ) on the pancreas of mice. The infection with CV-B4E2 of CD1 outbred mice treated with a sub-diabetogenic dose of STZ induced hyperglycemia and hypoinsulinemia. Along with the chemokine IP-10, viral RNA and infectious particles were detected in the pancreas. The pancreas of these animals was also marked with insulitis and other histological alterations. The model combining STZ and CV-B4E2 opens the door to new perspectives to better understand the interactions between virus and host, and the role of environmental factors capable, like STZ, to predispose the host to the diabetogenic effects of enteroviruses.
- Amebic Liver Abscess and Kawasaki Disease. [Journal Article]
- IPIndian Pediatr 2019 Jun 15; 56(6):504-505
- Co-occurrence of amebic hepatitis and Kawasaki disease has not been reported previously.
Co-occurrence of amebic hepatitis and Kawasaki disease has not been reported previously.
- Coxsackievirus-B4 Infection of Human Primary Pancreatic Ductal Cell Cultures Results in Impairment of Differentiation into Insulin-Producing Cells. [Journal Article]
- VViruses 2019 Jul 02; 11(7)
- Coxsackievirus-B4 (CV-B4) E2 can persist in the pancreatic ductal-like cells (Panc-1 cell line), which results in an impaired differentiation of these cells into islet-like cell aggregates (ICA). In …
Coxsackievirus-B4 (CV-B4) E2 can persist in the pancreatic ductal-like cells (Panc-1 cell line), which results in an impaired differentiation of these cells into islet-like cell aggregates (ICA). In this study, primary pancreatic ductal cells obtained as a by-product of islet isolation from the pancreas of seven brain-dead adults were inoculated with CV-B4 E2, followed-up for 29 days, and the impact was investigated. Viral titers in culture supernatants were analyzed throughout the culture. Intracellular viral RNA was detected by RT-PCR. Levels of ductal cell marker CK19 mRNA and of insulin mRNA were evaluated by qRT-PCR. The concentration of c-peptide in supernatants was determined by ELISA. Ductal cells exposed to trypsin and serum-free medium formed ICA and resulted in an increased insulin secretion. Ductal cells from five brain-dead donors were severely damaged by CV-B4 E2, whereas the virus persisted in cultures of cells obtained from the other two. The ICAs whose formation was induced on day 14 post-inoculation were scarce and appeared tiny in infected cultures. Also, insulin mRNA expression and c-peptide levels were strongly reduced compared to the controls. In conclusion, CV-B4 E2 lysed human primary pancreatic ductal cells or persisted in these cells, which resulted in the impairment of differentiation into insulin-producing cells.
- How to support open-source software and stay sane. [News]
- NatNature 2019; 571(7763):133-134
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- Spinal Cord Injury Due to Cervical Disc Herniation without Bony Involvement Caused by Wrestling - A Case Report. [Case Reports]
- JOJ Orthop Case Rep 2019 Jan-Feb; 9(1):19-22
- CONCLUSIONS: Competitive wrestling-related injuries are quite high. Fortunately, the incidence of SCI among wrestlers is extremely low. Although rare, SCI due to cervical disc herniation without bony involvement is a serious debilitating injury that exerts a devastating effect on a wrestler from a physical, psychological, and socioeconomic point of view, and places an immense burden on society from a public health perspective. The MRI is the golden examination in diagnosing such lesion. The management comprises surgical decompression of neural elements, stabilization, and fusion to provide a higher recovery rate from cord damage to return to play. Wrestler who is completely pain free with full range of motion and strength may be eligible for return to play.