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Unbound Medicine.
(SARS)
204,439 results
  • Experimental and computational methods for studying the dynamics of RNA-RNA interactions in SARS-COV2 genomes. [Journal Article]
    Brief Funct Genomics. 2023 Feb 07 [Online ahead of print]Srivastava M, Dukeshire MR, … Janga SC
  • Long-range ribonucleic acid (RNA)-RNA interactions (RRI) are prevalent in positive-strand RNA viruses, including Beta-coronaviruses, and these take part in regulatory roles, including the regulation of sub-genomic RNA production rates. Crosslinking of interacting RNAs and short read-based deep sequencing of resulting RNA-RNA hybrids have shown that these long-range structures exist in severe acut…
  • [Evaluation of COVID-19 Antigen Test Kit Assay Analytical and Clinical Performance]. [Journal Article]
    Zhongguo Yi Liao Qi Xie Za Zhi. 2023 Jan 30; 47(1):99-105.Jiang X, Du M, … Zheng M
  • Objective To rapidly screen patients with novel coronavirus pneumonia (COVID-19) infection including asymptomatic ones. Method Established a rapid detection test kit, and evaluated analytical and clinical performance of it. Result The minimum limit of detection of the reagent was 9.75×102 TCID50/mL; there was no cross-reaction and interference in the high-concentration samples of 29 common respir…
  • Two-Hit Kidney Allograft Injury by SARS-CoV-2. [Case Reports]
    Cureus. 2023 Feb; 15(2):e34603.Ribeiro B, Pontello Cristelli M, … Medina-Pestana J
  • Coronavirus disease 2019 (COVID-19) has been associated with acute kidney injury in kidney transplant recipients by several mechanisms. The authors report a case of acute kidney allograft dysfunction in a 48-year-old patient who presented in the emergency room with anasarca and nephrotic syndrome close after mild COVID-19 and no other clinical condition. Histopathology of the allograft biopsy rev…
  • Evolutionary rate of SARS-CoV-2 increases during zoonotic infection of farmed mink. [Journal Article]
    Virus Evol. 2023; 9(1):vead002.Porter AF, Purcell DFJ, … Duchene S
  • To investigate genetic signatures of adaptation to the mink host, we characterised the evolutionary rate heterogeneity in mink-associated severe acute respiratory syndrome coronaviruses (SARS-CoV-2). In 2020, the first detected anthropozoonotic spillover event of SARS-CoV-2 occurred in mink farms throughout Europe and North America. Both spill-back of mink-associated lineages into the human popul…
  • Immune profile of children diagnosed with multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C). [Journal Article]
    Cent Eur J Immunol. 2022; 47(2):151-159.Gowin E, Dworacki G, … Januszkiewicz-Lewandowska D
  • CONCLUSIONS: Children with MIS-C do not resemble adults during COVID-19 recovery. The immune profile of the studied patients differs from that of children with Kawasaki disease (KD), but it is similar to that of adults with severe COVID-19. The proposed explanation is a profound lymphopenia caused by SARS-CoV-2 infection - which persists for weeks - as a result leading to uncontrolled inflammation. In COVID-19 patients the T cell level returns to normal after the second week of the disease. Our data suggest that in children prolonged lymphopenia after COVID-19 can be a practical marker for possible MIS-C alert. If there is a continuum from lymphopenia to MIS-C, there is room for screening and prevention. Further studies are needed to determine whether steroid treatment introduced in a child with prolonged lymphopenia could stop the inflammatory process.
  • Autoimmune sclerosing cholangitis might be triggered by SARS-CoV-2 infection in a child - a case report. [Case Reports]
    Cent Eur J Immunol. 2022; 47(2):183-187.Zdanowicz K, Bobrus-Chociej A, … Lebensztejn DM
  • The spectrum of liver involvement during coronavirus disease 2019 (COVID-19) is broad and mainly includes elevated liver enzymes and cholestasis. Severe acute respiratory syndrome corona- virus-2 (SARS-CoV-2) infection most often leads to a transient moderate increase in liver enzymes that is not accompanied by disturbances in the synthetic function of the liver. However, there is increasing evid…
  • Acute Disseminated Encephalomyelitis Following COVID-19 Infection. [Case Reports]
    Cureus. 2023 Jan; 15(1):e33365.Assi F, Abdallah R, … Wazne J
  • Acute disseminated encephalomyelitis (ADEM) is a relatively rare, post-inflammatory, immune-mediated demyelinating central nervous system disease that is predominantly reported in pediatric populations. Following the emergence of severe acute respiratory syndrome coronavirus 2, cases of ADEM are being reported following infection with this virus. Our case report describes a male patient in his ea…
  • Magnetic hydrogel particles improve nanopore sequencing of SARS-CoV-2 and other respiratory viruses. [Journal Article]
    Sci Rep. 2023 Feb 07; 13(1):2163.Andersen P, Barksdale S, … Lepene B
  • Presented here is a magnetic hydrogel particle enabled workflow for capturing and concentrating SARS-CoV-2 from diagnostic remnant swab samples that significantly improves sequencing results using the Oxford Nanopore Technologies MinION sequencing platform. Our approach utilizes a novel affinity-based magnetic hydrogel particle, circumventing low input sample volumes and allowing for both rapid m…
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