- An Unusual Case of Severe Pneumonia Caused Due Candida Tropicalis With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community. [Journal Article]J Investig Med High Impact Case Rep. 2023 Jan-Dec; 11:23247096231154652.JI
- Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient. A 72-year-old man with a previous history of hypertension, ischemic stroke, and facial paralysis sequelae treated with the botulinic toxin, was admitte…
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- Experimental and computational methods for studying the dynamics of RNA-RNA interactions in SARS-COV2 genomes. [Journal Article]Brief Funct Genomics. 2023 Feb 07 [Online ahead of print]BF
- Long-range ribonucleic acid (RNA)-RNA interactions (RRI) are prevalent in positive-strand RNA viruses, including Beta-coronaviruses, and these take part in regulatory roles, including the regulation of sub-genomic RNA production rates. Crosslinking of interacting RNAs and short read-based deep sequencing of resulting RNA-RNA hybrids have shown that these long-range structures exist in severe acut…
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- [Evaluation of COVID-19 Antigen Test Kit Assay Analytical and Clinical Performance]. [Journal Article]Zhongguo Yi Liao Qi Xie Za Zhi. 2023 Jan 30; 47(1):99-105.ZY
- Objective To rapidly screen patients with novel coronavirus pneumonia (COVID-19) infection including asymptomatic ones. Method Established a rapid detection test kit, and evaluated analytical and clinical performance of it. Result The minimum limit of detection of the reagent was 9.75×102 TCID50/mL; there was no cross-reaction and interference in the high-concentration samples of 29 common respir…
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- Association of SARS-CoV-2 viral load with biochemical profile of COVID-19 patients: A nigerian experience. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):109-115.NJ
- CONCLUSIONS: COVID-19 patients with mild respiratory symptoms exhibited renal abnormalities, electrolytes, and acid-base imbalances which were partly associated with SARS-CoV-2 viral load.
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- Effect of omega-3 fatty acid use on sepsis and mortality in patients with Covıd-19. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):102-108.NJ
- CONCLUSIONS: Study results obtained in this study indicate that providing omega-3 fatty acid supplements may be beneficial to patients with severe COVİD-19, however further research with large-scale randomized controlled trials is necessary.
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- Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India. [Journal Article]Indian J Med Res. 2022 Sep; 156(3):484-499.IJ
- CONCLUSIONS: In COVID-19, LFT abnormalities were common, and derangement increased as severity progressed. The presence of deranged LFT worsens the clinical outcome and predicts in-hospital mortality.
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- Clinical and Epidemiology Characteristics of COVID-19 Cases Detected During Mass Screening Campaign from July to October 2020 in Bujumbura, Burundi. [Journal Article]East Afr Health Res J. 2022; 6(2):127-133.EA
- CONCLUSIONS: This study revealed that a significant proportion (32.5%) of COVID-19 patients were silent carriers of the virus. Data highlighted that high proportion of cases were among the active age group and contacts with confirmed cases, and noted high proportion of asymptomatic cases at diagnosis. Measures including routine testing of asymptomatic contacts could contribute to tackling corona virus in Burundi.
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- [Adolescents' and young people's experiences of health participation during the COVID-19 pandemic in ChileExperiências de participação de adolescentes e jovens na saúde em tempos de pandemia de COVID-19 no Chile]. [Journal Article]Rev Panam Salud Publica. 2023; 47:e27.RP
- CONCLUSIONS: The pandemic affected the participation mechanisms used by young people and adolescents in Chile; however, among the experiences highlighted by young people, aspects that facilitated participation emerged, such as virtual communication, digital health, and other strategies. At the same time, some gaps in health participation widened during this global health crisis, such as access mainly in rural populations.
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- Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofad001.OF
- CONCLUSIONS: Shared within-host variation may augment the information in consensus sequences for predicting transmission linkages. Improving sensitivity and specificity of within-host variant identification will improve the informativeness of within-host variation.
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- A Longitudinal Study of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response in a Subset of United States Blood Donors. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofac697.OF
- CONCLUSIONS: Healthy blood donors were vaccinated at high rates and remained mostly asymptomatic and noninfected, whereas approximately two thirds of infected donors reported symptoms. Anti-S1 levels increased while anti-N decreased over 18 months but remained comparable between vaccinated and hybrid immune individuals with dramatic anti-S1 increases after vaccination or boosting.
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- Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury. [Journal Article]Clin Kidney J. 2023 Feb; 16(2):272-284.CK
- CONCLUSIONS: Elevated uACE2 is related to AKI in patients with COVID-19. The loss of tubular ACE2 during SARS-CoV-2 infection demonstrates a potential link between aminoaciduria and proximal tubular injury.
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- Acute and chronic kidney disease and risk of hospital mortality during COVID-19 pandemic waves in the pre-vaccination era. [Journal Article]Clin Kidney J. 2023 Feb; 16(2):374-383.CK
- CONCLUSIONS: In conclusion, CKD and AKI were common in pre-vaccination waves among hospitalized COVID-19 patients and were independent risk factors for death, even when AKI was mild to moderate, and despite improvements in treatment.
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- Two-Hit Kidney Allograft Injury by SARS-CoV-2. [Case Reports]Cureus. 2023 Feb; 15(2):e34603.C
- Coronavirus disease 2019 (COVID-19) has been associated with acute kidney injury in kidney transplant recipients by several mechanisms. The authors report a case of acute kidney allograft dysfunction in a 48-year-old patient who presented in the emergency room with anasarca and nephrotic syndrome close after mild COVID-19 and no other clinical condition. Histopathology of the allograft biopsy rev…
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- Surveillance and Analysis of SARS-CoV-2 Variant Importation - China, January-June 2022. [Journal Article]China CDC Wkly. 2022 Dec 16; 4(50):1136-1142.CC
- CONCLUSIONS: The Omicron variant showed the intra-Omicron evolution in the first half of 2022, and all of the Omicron subvariants were introduced into the mainland of China multiple times from multiple different locations.
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- Characteristics and Containment of 74 Imported COVID-19 Outbreaks: Experiences, Lessons, and Implications - China, 2020-2021. [Journal Article]China CDC Wkly. 2022 Dec 16; 4(50):1131-1135.CC
- After the initial coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematically documented.
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- COVID-19 severity and in-hospital mortality in an area with high HIV prevalence. [Journal Article]South Afr J HIV Med. 2023; 24(1):1412.SA
- CONCLUSIONS: PLWH were not at increased risk of mortality and those with detectable HIVVL had less severe respiratory disease than those with suppressed HIVVL.
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- Mobile SARS‑CoV‑2 screening facilities for rapid deployment and university-based diagnostic laboratory. [Journal Article]Eng Life Sci. 2023 Feb; 23(2):2200026.EL
- The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created a public crisis. Many medical and public institutions and businesses went into isolation in response to the pandemic. Because SARS-CoV-2 can spread irrespective of a patient's course of disease, these institutions' continued operation or reopening based on the assessment and control of virus spread can be suppor…
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- Evolutionary rate of SARS-CoV-2 increases during zoonotic infection of farmed mink. [Journal Article]Virus Evol. 2023; 9(1):vead002.VE
- To investigate genetic signatures of adaptation to the mink host, we characterised the evolutionary rate heterogeneity in mink-associated severe acute respiratory syndrome coronaviruses (SARS-CoV-2). In 2020, the first detected anthropozoonotic spillover event of SARS-CoV-2 occurred in mink farms throughout Europe and North America. Both spill-back of mink-associated lineages into the human popul…
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- A simulation approach for COVID-19 pandemic assessment based on vaccine logistics, SARS-CoV-2 variants, and spread rate. [Journal Article]Simulation. 2023 Feb; 99(2):127-135.S
- Despite advances in clinical care for the coronavirus (COVID-19) pandemic, population-wide interventions are vital to effectively manage the pandemic due to its rapid spread and the emergence of different variants. One of the most important interventions to control the spread of the disease is vaccination. In this study, an extended Susceptible-Infected Healed (SIR) model based on System Dynamics…
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- Immune profile of children diagnosed with multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C). [Journal Article]Cent Eur J Immunol. 2022; 47(2):151-159.CE
- CONCLUSIONS: Children with MIS-C do not resemble adults during COVID-19 recovery. The immune profile of the studied patients differs from that of children with Kawasaki disease (KD), but it is similar to that of adults with severe COVID-19. The proposed explanation is a profound lymphopenia caused by SARS-CoV-2 infection - which persists for weeks - as a result leading to uncontrolled inflammation. In COVID-19 patients the T cell level returns to normal after the second week of the disease. Our data suggest that in children prolonged lymphopenia after COVID-19 can be a practical marker for possible MIS-C alert. If there is a continuum from lymphopenia to MIS-C, there is room for screening and prevention. Further studies are needed to determine whether steroid treatment introduced in a child with prolonged lymphopenia could stop the inflammatory process.
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- Autoimmune sclerosing cholangitis might be triggered by SARS-CoV-2 infection in a child - a case report. [Case Reports]Cent Eur J Immunol. 2022; 47(2):183-187.CE
- The spectrum of liver involvement during coronavirus disease 2019 (COVID-19) is broad and mainly includes elevated liver enzymes and cholestasis. Severe acute respiratory syndrome corona- virus-2 (SARS-CoV-2) infection most often leads to a transient moderate increase in liver enzymes that is not accompanied by disturbances in the synthetic function of the liver. However, there is increasing evid…
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- Malignant middle cerebral artery syndrome with thrombotic thrombocytopenia following vaccination against SARS-CoV-2. [Journal Article]J Intensive Care Soc. 2022 Nov; 23(4):479-484.JI
- Cases of thromboses at unusual sites with thrombocytopenia have been reported following vaccination against Sars-CoV-2. This new syndrome, christened vaccine-induced thrombotic thrombocytopenia (VITT), mainly results in venous thromboses. We report the case of a young woman with a right middle cerebral artery stroke following vaccination with ChAdOx1 nCoV-19. A diagnosis of VITT was made and plat…
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- Acute Disseminated Encephalomyelitis Following COVID-19 Infection. [Case Reports]Cureus. 2023 Jan; 15(1):e33365.C
- Acute disseminated encephalomyelitis (ADEM) is a relatively rare, post-inflammatory, immune-mediated demyelinating central nervous system disease that is predominantly reported in pediatric populations. Following the emergence of severe acute respiratory syndrome coronavirus 2, cases of ADEM are being reported following infection with this virus. Our case report describes a male patient in his ea…
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- Clinical Research: A Review of Study Designs, Hypotheses, Errors, Sampling Types, Ethics, and Informed Consent. [Review]Cureus. 2023 Jan; 15(1):e33374.C
- Recently, we have been noticing an increase in the emergence and re-emergence of microbial infectious diseases. In the previous 100 years, there were several incidences of pandemics caused by different microbial species like the influenza virus, human immunodeficiency virus (HIV), dengue virus, severe acute respiratory syndrome Coronavirus (SARS-CoV), middle east respiratory syndrome coronavirus …
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- Traditional Vietnamese medicine Kovir capsule for non-severe COVID-19 patients: A phase III double-blind randomized controlled trial. [Journal Article]Phytother Res. 2023 Feb 07 [Online ahead of print]PR
- The number of COVID-19 infections is still increasing with the omicron variant. Although vaccination has shown its effectiveness, efficacious treatments are still required. Kovir, a Vietnamese herbal medicine, has shown potential effects for non-severe COVID-19 patients in terms of symptom resolution and prevention of disease progression in previous studies. This phase-3 trial evaluated the safet…
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- Do not "MIS-C" the cancer: A case report of balancing the timing of concurrent treatment for MIS-C and incidentally diagnosed pediatric Wilms tumor. [Letter]Pediatr Blood Cancer. 2023 Feb 07 [Online ahead of print]PB
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- A comparison of four epidemic waves of COVID-19 in Malawi; an observational cohort study. [Journal Article]BMC Infect Dis. 2023 Feb 07; 23(1):79.BI
- CONCLUSIONS: Our data show that each wave of patients hospitalised with SARS-CoV-2 was infected with a distinct viral variant. The clinical data suggests that patients with severe COVID-19 disease were more likely to die during the Delta wave.
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- Alfabetización sanitaria y COVID-19 en países de ingreso bajo, medio y medio alto: revisión sistemática. [Journal Article]Glob Health Promot. 2023 Feb 07 [Online ahead of print]GH
- analizar las publicaciones de Alfabetización Sanitaria (AS) en relación con la pandemia de la COVID-19 en países de ingreso bajo, medio y medio-alto.
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- Magnetic hydrogel particles improve nanopore sequencing of SARS-CoV-2 and other respiratory viruses. [Journal Article]Sci Rep. 2023 Feb 07; 13(1):2163.SR
- Presented here is a magnetic hydrogel particle enabled workflow for capturing and concentrating SARS-CoV-2 from diagnostic remnant swab samples that significantly improves sequencing results using the Oxford Nanopore Technologies MinION sequencing platform. Our approach utilizes a novel affinity-based magnetic hydrogel particle, circumventing low input sample volumes and allowing for both rapid m…
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- COVID drug drives viral mutations - and now some want to halt its use. [News]Nature. 2023 Feb 07 [Online ahead of print]Nat
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