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3,120 results
  • What patents tell us about drug repurposing for cancer: A landscape analysis. [Review]
    Semin Cancer Biol 2019Mucke HAM
  • Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing for cancer that were published under the Patent Convention Treaty during the past …
  • Acute Management of Pediatric Cyclic Vomiting Syndrome: A Systematic Review. [Journal Article]
    J Pediatr 2019Gui S, Patel N, … Kam AJ
  • CONCLUSIONS: Ondansetron has the most quantitative and qualitative evidence to support its inclusion in pediatric emergency department protocols as a rescue therapy. Sumatriptan and aprepitant are potential candidates for inclusion as abortive therapies. Qualitative data from retrospective studies and case reports are not applicable to a larger patient population. This report informs a need for controlled, prospective cohort studies and randomized, controlled trials to optimize current management protocols and to develop new medical interventions.
  • Management of Childhood Headache in the Emergency Department. Review of the Literature. [Review]
    Front Neurol 2019; 10:886Raucci U, Della Vecchia N, … Parisi P
  • Headache is the third cause of visits to pediatric emergency departments (ED). According to a systematic review, headaches in children evaluated in the ED are primarily due to benign conditions that tend to be self-limiting or resolve with appropriate pharmacological treatment. The more frequent causes of non-traumatic headache in the ED include primitive headaches (21.8-66.3%) and benign seconda…
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