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(Schizophrenia)
139,696 results
  • Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice. [Journal Article]
    Neuron 2019Mukai J, Cannavò E, … Gogos JA
  • SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations in axonal branching and cortical synaptic dynamics accompanied by working memory deficits. We show that Setd1a binds both promoters and enhancers with a striking overlap between Setd1a and Mef2 on enhancers. Setd1a targe…
  • Use of tobacco in schizophrenia: A double-edged sword. [Journal Article]
    Brain Behav 2019; :e01433Fang Y, Wang W, … Cui D
  • CONCLUSIONS: This study supports the self-medication hypothesis. Nonetheless, considering the serious health hazard associated with tobacco use, we should encourage patients to stop smoking. Further investigations are warranted to determine the tobacco constituents that are beneficial or harmful to schizophrenia.
  • [Revised S3 guidelines on schizophrenia : Developmental process and selected recommendations]. [Review]
    Nervenarzt 2019Hasan A, Falkai P, … Gaebel W
  • Schizophrenia is one of the most severe mental diseases and leads to significant personal and social impairments for affected persons. The illness is characterized by frequent relapses, results in increased mortality and is associated with the highest socioeconomic costs of all diseases. Moreover, patients with schizophrenia are often stigmatized in everyday life and also in most treatment settin…
  • How and when to use clozapine. [Journal Article]
    Acta Psychiatr Scand 2019Rubio JM, Kane JM
  • CONCLUSIONS: Clozapine prescription is one of the areas in psychiatry with the greatest mismatch between efficacy and utilization in clinical practice. Although multiple barriers to the use of clozapine exist, some of these may be overcome by updates of routine clinical practice.
  • Blindness, Psychosis, and the Visual Construction of the World. [Journal Article]
    Schizophr Bull 2019Pollak TA, Corlett PR
  • The relationship between visual loss and psychosis is complex: congenital visual loss appears to be protective against the development of a psychotic disorder, particularly schizophrenia. In later life, however, visual deprivation or visual loss can give rise to hallucinosis, disorders of visual insight such as blindsight or Anton syndrome, or, in the context of neurodegenerative disorders, more …
  • Choroid Plexus Enlargement and Allostatic Load in Schizophrenia. [Journal Article]
    Schizophr Bull 2019Zhou YF, Huang JC, … Hong LE
  • Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct evidence of brain structures involved in the presumed peripheral-central interaction in schizophrenia is still unclear. Seventy-nine previously treatment-naïve first-episode schizophrenia patients who were within 2-week antipsychotics initial stabilizat…
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