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(Schultze mechanism)
61 results
  • Light-wave dynamic control of magnetism. [Journal Article]
    Nature 2019; 571(7764):240-244Siegrist F, Gessner JA, … Schultze M
  • The enigmatic interplay between electronic and magnetic phenomena observed in many early experiments and outlined in Maxwell's equations propelled the development of modern electromagnetism1. Today, the fully controlled evolution of the electric field of ultrashort laser pulses enables the direct and ultrafast tuning of the electronic properties of matter, which is the cornerstone of light-wave e…
  • Innate immune memory in the brain shapes neurological disease hallmarks. [Journal Article]
    Nature 2018; 556(7701):332-338Wendeln AC, Degenhardt K, … Neher JJ
  • Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages i…
  • Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. [Journal Article]
    J Clin Invest 2018; 128(5):1852-1866Vogl T, Stratis A, … Roth J
  • Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived signals, such as danger-associated molecular patterns (DAMPs), are indispensable for manifestation of local inflammation. S100A8/S100A9 complexes are the most abundant DAMPs in many autoimmune diseases. However, regul…
  • A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. [Journal Article]
    Sci Rep 2017; 7(1):4056Aschenbrenner AC, Bassler K, … Hoch M
  • There is an enormous need to make better use of the ever increasing wealth of publicly available genomic information and to utilize the tremendous progress in computational approaches in the life sciences. Transcriptional regulation of protein-coding genes is a major mechanism of controlling cellular functions. However, the myriad of transcription factors potentially controlling transcription of …
  • Chromatin Remodeling in Monocyte and Macrophage Activation. [Review]
    Adv Protein Chem Struct Biol 2017; 106:1-15Schultze JL
  • Increasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditio…
  • Macrophage tolerance in the gut: It is in the epigenome! [Comment]
    Eur J Immunol 2016; 46(8):1838-41Schultze JL
  • Intestinal macrophages are functionally specialized to phagocytose bacteria, including harmful and invading pathogens, without releasing pro-inflammatory mediators. This unique functional combination guarantees an optimal defense against millions of gut bacteria while at the same time protecting the host from inflammation-related tissue damage. IL-10 seems to be a critical tissue factor involved …
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