Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Science[JO] AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV))
119 results
  • Introductions and early spread of SARS-CoV-2 in the New York City area. [Journal Article]
    Science. 2020 May 29 [Online ahead of print]Gonzalez-Reiche AS, Hernandez MM, … van Bakel H
  • New York City (NYC) has emerged as one of the epicenters of the current SARS-CoV-2 pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus causing COVID-19 in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV2 genomes indicates multiple, independent but iso…
  • SARS-CoV-2 infection protects against rechallenge in rhesus macaques. [Journal Article]
    Science. 2020 May 20 [Online ahead of print]Chandrashekar A, Liu J, … Barouch DH
  • An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower …
  • DNA vaccine protection against SARS-CoV-2 in rhesus macaques. [Journal Article]
    Science. 2020 May 20 [Online ahead of print]Yu J, Tostanoski LH, … Barouch DH
  • The global COVID-19 pandemic caused by the SARS-CoV-2 virus has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers…
  • Susceptible supply limits the role of climate in the early SARS-CoV-2 pandemic. [Journal Article]
    Science. 2020 May 18 [Online ahead of print]Baker RE, Yang W, … Grenfell BT
  • Preliminary evidence suggests that climate may modulate the transmission of SARS-CoV-2. Yet it remains unclear whether seasonal and geographic variations in climate can substantially alter the pandemic trajectory, given high susceptibility is a core driver. Here, we use a climate-dependent epidemic model to simulate the SARS-CoV-2 pandemic probing different scenarios based on known coronavirus bi…
  • Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions. [Journal Article]
    Science. 2020 May 15 [Online ahead of print]Dehning J, Zierenberg J, … Priesemann V
  • As COVID-19 is rapidly spreading across the globe, short-term modeling forecasts provide time-critical information for decisions on containment and mitigation strategies. A major challenge for short-term forecasts is the assessment of key epidemiological parameters and how they change when first interventions show an effect. By combining an established epidemiological model with Bayesian inferenc…
  • A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2. [Journal Article]
    Science. 2020 May 13 [Online ahead of print]Wu Y, Wang F, … Liu L
  • Neutralizing antibodies could be antivirals against COVID-19 pandemics. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. B38 and H4 block the binding between virus S-protein RBD and cellular receptor ACE2. A competition assay indicates their different epitopes on the RBD, making them a potential virus-…
  • Estimating the burden of SARS-CoV-2 in France. [Journal Article]
    Science. 2020 May 13 [Online ahead of print]Salje H, Tran Kiem C, … Cauchemez S
  • France has been heavily affected by the SARS-CoV-2 epidemic and went into lockdown on the 17 March 2020. Using models applied to hospital and death data, we estimate the impact of the lockdown and current population immunity. We find 3.6% of infected individuals are hospitalized and 0.7% die, ranging from 0.001% in those <20 years of age (ya) to 10.1% in those >80ya. Across all ages, men are more…
  • Rapid development of an inactivated vaccine candidate for SARS-CoV-2. [Journal Article]
    Science. 2020 May 06 [Online ahead of print]Gao Q, Bao L, … Qin C
  • The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are currently no SARS-CoV-2-specific treatments or vaccines available due to the novelty of the virus. Hence, rapid development of effective vaccines against SARS-CoV-2 are urgently needed. Here we developed a pilot-sc…
  • Rapid implementation of mobile technology for real-time epidemiology of COVID-19. [Journal Article]
    Science. 2020 May 05 [Online ahead of print]Drew DA, Nguyen LH, … COPE Consortium
  • The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (COVID-19) presents challenges to the robust collection of population-scale data to address this global health crisis. We established the COronavirus Pandemic Epidemiology (COPE) consortium to bring together scientists with expertise in big data research and epidemiology to develop a COVID-19 Symptom Track…
  • Site-specific glycan analysis of the SARS-CoV-2 spike. [Journal Article]
    Science. 2020 May 04 [Online ahead of print]Watanabe Y, Allen JD, … Crispin M
  • The emergence of the betacoronavirus, SARS-CoV-2, the causative agent of COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, which mediates cell entry and membrane fusion. SARS-CoV-2 S gene encodes 22 N-linked glycan sequons per protomer, which likely play a role in pro…
New Search Next