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(Science[JO] AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV))
499 results
  • Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. [Journal Article]
    Science. 2021 Jul 20 [Online ahead of print]Drayman N, DeMarco JK, … Tay S
  • There is an urgent need for antiviral agents that treat SARS-CoV-2 infection. We screened a library of 1,900 clinically safe drugs against OC43, a human beta-coronavirus that causes the common cold and evaluated the top hits against SARS-CoV-2. Twenty drugs significantly inhibited replication of both viruses in vitro. Eight of these drugs inhibited the activity of the SARS-CoV-2 main protease, 3C…
  • An isoform of Dicer protects mammalian stem cells against multiple RNA viruses. [Journal Article]
    Science. 2021 07 09; 373(6551):231-236.Poirier EZ, Buck MD, … Reis E Sousa C
  • In mammals, early resistance to viruses relies on interferons, which protect differentiated cells but not stem cells from viral replication. Many other organisms rely instead on RNA interference (RNAi) mediated by a specialized Dicer protein that cleaves viral double-stranded RNA. Whether RNAi also contributes to mammalian antiviral immunity remains controversial. We identified an isoform of Dice…
  • Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice. [Journal Article]
    Science. 2021 Jun 22 [Online ahead of print]Martinez DR, Schäfer A, … Baric RS
  • The emergence of SARS-CoV in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirus subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV) RsSHC014, and a heterologous Bt-CoV WIV-1 in vulnerable aged mice. Chimeric spike mRNAs induced h…
  • SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern. [Journal Article]
    Science. 2021 Jul 01 [Online ahead of print]McCallum M, Bassi J, … Veesler D
  • A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based mRNA vaccine or convalescent individuals exhibited neutralizing titers, which were …
  • Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. [Journal Article]
    Science. 2021 Jul 01 [Online ahead of print]Wang L, Zhou T, … Misasi J
  • The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. We identify four receptor-binding domain targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 23 variants including the B.1.1.7, B.1.351, P.1, B.1…
  • Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. [Journal Article]
    Science. 2021 Jun 24 [Online ahead of print]Gobeil SM, Janowska K, … Acharya P
  • SARS-CoV-2 variants with multiple spike mutations enable increased transmission and antibody resistance. Here, we combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. All variants showed increased ACE2 receptor binding and increased propensi…
  • Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. [Journal Article]
    Science. 2021 Jun 24 [Online ahead of print]Cai Y, Zhang J, … Chen B
  • Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19 pandemic. We report here cryo-EM structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their biochemical and antigenic properties. Amino acid substitutions in the B.1.1.7 protein increase the accessib…
  • Senolytics reduce coronavirus-related mortality in old mice. [Journal Article]
    Science. 2021 Jun 08 [Online ahead of print]Camell CD, Yousefzadeh MJ, … Robbins PD
  • The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically-ill to SARS-CoV-2-induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic diseases, and age-related dysfunction, but effects on responses to viral infection are unclear. Here, we demonstrate that senescent cells (SnC) become hyper-inflammatory in response to pa…
  • Estimating epidemiologic dynamics from cross-sectional viral load distributions. [Journal Article]
    Science. 2021 Jun 03 [Online ahead of print]Hay JA, Kennedy-Shaffer L, … Mina MJ
  • Estimating an epidemic's trajectory is crucial for developing public health responses to infectious diseases, but case data used for such estimation are confounded by variable testing practices. We show that the population distribution of viral loads observed under random or symptom-based surveillance, in the form of cycle threshold (Ct) values obtained from reverse-transcription quantitative pol…
  • Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets. [Journal Article]
    Science. 2021 07 09; 373(6551):236-241.Maio N, Lafont BAP, … Rouault TA
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes. We found that the catalytic subunit of the RdRp, nsp12, ligates two iron-sulfur metal cofactors in sites that were modeled as zinc centers in the available cryo-electron microscopy structures o…
  • Estimating infectiousness throughout SARS-CoV-2 infection course. [Journal Article]
    Science. 2021 07 09; 373(6551)Jones TC, Biele G, … Drosten C
  • Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Germany, including 6110 from test centers attended by presymptomatic, asymptomatic, and mildly symptomatic (PAMS) subjects, 9519 who were hospitalized…
  • Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. [Journal Article]
    Science. 2021 06 18; 372(6548):1306-1313.Bhatt PR, Scaiola A, … Ban N
  • Programmed ribosomal frameshifting is a key event during translation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the viral RNA-dependent RNA polymerase and downstream proteins. Here, we present the cryo-electron microscopy structure of a translating mammalian ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseu…
  • Face masks effectively limit the probability of SARS-CoV-2 transmission. [Journal Article]
    Science. 2021 May 20 [Online ahead of print]Cheng Y, Ma N, … Su H
  • Airborne transmission by droplets and aerosols is important for the spread of viruses. Face masks are a well-established preventive measure, but their effectiveness for mitigating SARS-CoV-2 transmission is still under debate. We show that variations in mask efficacy can be explained by different regimes of virus abundance and related to population-average infection probability and reproduction n…
  • Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. [Journal Article]
    Science. 2021 May 20 [Online ahead of print]Yuan M, Huang D, … Wilson IA
  • Neutralizing antibodies (nAbs) elicited against the receptor-binding site (RBS) of the spike protein of wild-type SARS-CoV-2 are generally less effective against recent variants of concern. RBS residues E484, K417 and N501 are mutated in variants first described in South Africa (B.1.351) and Brazil (P.1). We analyzed their effects on ACE2 binding and K417N and E484K mutations on nAbs isolated fro…
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