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(Scleroderma Renal Disease)
1,695 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Pulmonary Arterial Hypertension Agents [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Pulmonary artery hypertension (PAH) is marked by proliferation of vasculature and remodeling of small pulmonary arteries which causes an increase in pulmonary vascular resistance. The resultant pulmonary artery hypertension can lead to right heart failure and death. Both endothelial and smooth muscle cells appear to play a role in the development and progression of PAH. The underlying cause of mo…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Penicillamine [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Penicillamine is chelating agent used to decrease copper stores in Wilson disease, which also has immunomodulatory activity in rheumatic diseases such as rheumatoid arthritis, scleroderma and systemic lupus erythematosus. Penicillamine is capable of causing hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic.
  • Is there today a place for corticosteroids in the treatment of scleroderma? [Review]
    Autoimmun Rev 2019; 18(12):102403Blagojevic J, Legendre P, … Mouthon L
  • In systemic sclerosis (SSc), the use of corticosteroids (CS) is controversial due to their association with scleroderma renal crisis (SRC). However, patients with very early and early disease, characterised by main inflammatory component, may benefit from CS therapy. The aim of this review is to discuss pros and cons of CS treatment in SSc, providing current evidence about the use of CS in SSc. M…
  • Demyelinating syndrome in systemic sclerosis and neuromyelitis optica. [Case Reports]
    BMC Neurol 2019; 19(1):234Deeb K, Eby J, Labault-Santiago J
  • CONCLUSIONS: This article expands on NMOSD associated autoimmune diseases. Systemic Sclerosis is an insidious disease that is often diagnosed late as not all patients often report skin manifestation. The finding suggests that patients presenting with acute neurological manifestations get tested for NMO-IgG/AQP-4 antibodies and other immunological studies based on clinical findings.
  • Renal pathology and clinical associations in systemic sclerosis: a historical cohort study. [Journal Article]
    Int J Gen Med 2019; 12:323-331Tonsawan P, Talabthong K, … Foocharoen C
  • CONCLUSIONS: This is the first report of renal pathologic findings in Thai SSc patients. RPGN is the commonest renal manifestation among SSc who underwent kidney biopsy; for whom LN was the most common pathological finding. Nephrotic syndrome is a clinical feature of glomerular diseases other than renal involvement in SSc.
  • Targeting metabolic dysregulation for fibrosis therapy. [Review]
    Nat Rev Drug Discov 2020; 19(1):57-75Zhao X, Kwan JYY, … Liu FF
  • Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and there are currently no therapies that can prevent or reverse fibrosis. Metabolic alterations are increasingly recognized as an important pathogenic process that underlies fibrosis across many organ types. As a result, met…
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