- Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2. [Journal Article]
- EREpilepsy Res 2018 Jun 18; 145:93-101
- CONCLUSIONS: LCM protected against pilocarpine-induced SE, associated neurodegeneration and improved pilocarpine-associated impairment of spatial memory. The study reveals that CRMP-2 may not be mediating the inverted-U-response of LCM at least in pilocarpine model. Therefore, the anti-oxidant effect of LCM (and not its ability to modulate CRMP-2) was anticipated as the mechanism underlying neuroprotection.
- Clinical outcome of recurrent afebrile seizures in children with benign convulsions associated with mild gastroenteritis. [Journal Article]
- SSeizure 2018 May 30; 60:110-114
- CONCLUSIONS: All the recurrent afebrile seizures initially diagnosed as CwG, irrespective of the kinds and frequency of relapses, showed favorable prognoses. CwG maybe falls within the category of situation-related seizures, rather than epilepsy.
- Comparison of cytokines and prooxidants/antioxidants markers among adults with refractory versus well-controlled epilepsy: A cross-sectional study. [Journal Article]
- SSeizure 2018 Jun 15; 60:105-109
- CONCLUSIONS: The mean serum IL-6 and oxidative stress levels in refractory epilepsy patients were higher and the serum adiponectin level was lower than the healthy control group. These findings may be associated with an increased risk of seizures, atherosclerosis and cardiovascular disease in refractory epilepsy patients.
- Graft Versus Host Disease of the Central Nervous System after Liver Transplantation: A Rare Complication. [Case Reports]
- AJAm J Transplant 2018 Jun 23
- Graft versus host disease (GVHD) of the central nervous system (CNS) following solid organ transplantation is a rare but serious complication and has been previously reported after bone marrow transp...
Graft versus host disease (GVHD) of the central nervous system (CNS) following solid organ transplantation is a rare but serious complication and has been previously reported after bone marrow transplantation. GVHD after liver transplantation is a rare entity with a high mortality rate. We report the case of a patient who developed GVHD and subsequently had seizures and altered mental status after deceased donor liver transplantation. The diagnosis of GVHD of the CNS was established by Short Tandem Repeat (STR) loci analysis of the CSF using PCR technique and gene mapping software. To our knowledge this is the first reported case of CNS-GVHD following liver transplantation. He eventually succumbed to sepsis and multi-organ failure and death, in keeping with the overall poor prognosis of CNS-GVHD. This article is protected by copyright. All rights reserved.
- Magnetic resonance imaging of arterial stroke mimics: a pictorial review. [Review]
- IIInsights Imaging 2018 Jun 22
- CONCLUSIONS: • About 30% of sudden neurological deficits are due to non-ischaemic causes. • MRI is the best technique to identify stroke mimics. • Our practical illustrated algorithm based on DWI helps to recognise stroke mimics.
- Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. [Journal Article]
- MNMol Neurobiol 2018 Jun 22
- Temporal lobe epilepsy (TLE) represents a devastating neurological condition, in which approximately 4/5 of patients remain refractory for anti-convulsive drugs. Epilepsy surgery biopsies often revea...
Temporal lobe epilepsy (TLE) represents a devastating neurological condition, in which approximately 4/5 of patients remain refractory for anti-convulsive drugs. Epilepsy surgery biopsies often reveal the damage pattern of "hippocampal sclerosis" (HS) characterized not only by neuronal loss but also pronounced astrogliosis and inflammatory changes. Since TLE shares distinct pathogenetic aspects with multiple sclerosis (MS), we have here scrutinized therapeutic effects in experimental TLE of the immunmodulator fingolimod, which is established in MS therapy. Fingolimod targets sphingosine-phosphate receptors (S1PRs). mRNAs of fingolimod target S1PRs were augmented in two experimental post status epilepticus (SE) TLE mouse models (suprahippocampal kainate/pilocarpine). SE frequently induces chronic recurrent seizures after an extended latency referred to as epileptogenesis. Transient fingolimod treatment of mice during epileptogenesis after suprahippocampal kainate-induced SE revealed substantial reduction of chronic seizure activity despite lacking acute attenuation of SE itself. Intriguingly, fingolimod exerted robust anti-convulsive activity in kainate-induced SE mice treated in the chronic TLE stage and had neuroprotective and anti-gliotic effects and reduced cytotoxic T cell infiltrates. Finally, the expression profile of fingolimod target-S1PRs in human hippocampal biopsy tissue of pharmacoresistant TLE patients undergoing epilepsy surgery for seizure relief suggests repurposing of fingolimod as novel therapeutic perspective in focal epilepsies.
- Incidence of childhood epilepsy: A population-based study in rural Japan. [Journal Article]
- BDBrain Dev 2018 Jun 19
- CONCLUSIONS: The annual incidence of childhood epilepsy in rural areas of Japan is generally comparable with rates of childhood epilepsy reported in other countries.
- New and Emerging Illicit Psychoactive Substances. [Review]
- MCMed Clin North Am 2018; 102(4):697-714
- Several novel psychoactive substances have emerged in recent years. Users are typically young men who use other substances. In the category of stimulants, cathinones ("bath salts") have predominated ...
Several novel psychoactive substances have emerged in recent years. Users are typically young men who use other substances. In the category of stimulants, cathinones ("bath salts") have predominated and can lead to agitation, psychosis, hyperthermia, and death. Synthetic cannabinoids ("spice") are more potent than marijuana and can lead to agitation, psychosis, seizures, and death. There are no rapid tests to identify these substances and general treatment includes benzodiazepines for agitation and supportive therapy. Many Synthetic opioids are potent analogues of fentanyl and carry a high risk of overdose. In addition, there are several designer benzodiazepines that have emerged.
- [The Role of Blood-Brain Barrier in the Development of Childhood Febrile Seizures and Temporal Lobe Epilepsy.] [Journal Article]
- FCFiziol Cheloveka 2016; 42(5):130-136
- Blood-brain barrier (BBB) of the central nervous system (CNS) is a physiological barrier that makes it possible to control the exchange of ions, molecules and cells between blood and tissue and to pr...
Blood-brain barrier (BBB) of the central nervous system (CNS) is a physiological barrier that makes it possible to control the exchange of ions, molecules and cells between blood and tissue and to prevent their free inflow into the brain. BBB is crucial for maintenance of brain homeostasis. BBB damage accompanies many degenerative, neurological and inflammatory (infectious or noninfectious) diseases and pathological states. Current review reports about BBB role in development of childhood febrile seizures and temporal lobe epi- lepsy.
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- [The expression of calcium sensing receptor(CaSR) and MAPK pathway changes in myocardial cells of epilepsy rats]. [Journal Article]
- ZYZhongguo Ying Yong Sheng Li Xue Za Zhi 2016 May 08; 32(5):454-458
- CONCLUSIONS: The level of CaSR expression increased in chronic epileptic rat model. CaSR activated the expressions of MAPK of the myocardial cells,andthen influenced the cardiac myocyte apoptosis.