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(Sick sinus syndrome)
3,477 results
  • A rare missense mutation in MYH6 associates with non-syndromic coarctation of the aorta. [Journal Article]
  • EHEur Heart J 2018 Mar 24
  • Bjornsson T, Thorolfsdottir RB, … Stefansson K
  • CONCLUSIONS: Through a population approach, we found that a rare missense mutation p.Arg721Trp in the sarcomere gene MYH6 has a strong effect on the risk of CoA and explains a substantial fraction of the Icelanders with CoA. This is the first mutation associated with non-familial or sporadic form of CoA at a population level. The p.Arg721Trp in MYH6 causes a cardiac syndrome with highly variable expressivity and emphasizes the importance of sarcomere integrity for cardiac development and function.
  • A case ofBrucella melitensisendocarditis in a patient with cardiovascular implantable electronic device. [Journal Article]
  • IDInfect Drug Resist 2018; 11:387-390
  • Al-Adsani W, Ahmad A, Al-Mousa M
  • CONCLUSIONS: In all published studies onBrucellainfective endocarditis with a cardiovascular implantable device, the recommendation was for device removal and extended treatment with doxycycline combined with rifampin and/or trimethoprim-sulfamethoxazole, plus parenteral aminoglycosides for the first 3 weeks. There have been two cases in the literature that have studied CIED infected with brucellosis where an attempt was made to retain the device. In both cases, relapse occurred upon discontinuation of treatment. It is not clear whether lifelong antibiotic suppression treatment would prevent relapse.
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