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855 results
  • Metabolic engineering of Clostridium thermocellum for n-butanol production from cellulose. [Journal Article]
    Biotechnol Biofuels 2019; 12:186Tian L, Conway PM, … Lynd LR
  • CONCLUSIONS: Here we report engineering C. thermocellum to produce n-butanol. Our initial pathway designs resulted in low levels (88 mg/L) of n-butanol production. By engineering the protein sequence of key enzymes in the pathway, we increased the n-butanol titer by 2.2-fold. We further increased n-butanol production by adding ethanol to the growth media. By combining all these improvements, the engineered strain was able to produce 357 mg/L of n-butanol from cellulose within 120 h.
  • Phyloproteomic and functional analyses do not support a split in the genus Borrelia (phylum Spirochaetes). [Journal Article]
    BMC Evol Biol 2019; 19(1):54Estrada-Peña A, Cabezas-Cruz A
  • CONCLUSIONS: We found only marginal functional differences among Borrelia species. Phyloproteomic networks that included all pairwise combinations between species, proteins, and processes were more effective than other methods for evaluating the evolutionary relationships among taxa. With the limitations of data availability, our results did not support a split of the arthropod-transmitted spirochaetes into the proposed genera, Borrelia and Borreliella.
  • The chemodiversity of paddy soil dissolved organic matter correlates with microbial community at continental scales. [Journal Article]
    Microbiome 2018; 6(1):187Li HY, Wang H, … Zhang ZJ
  • CONCLUSIONS: Our study demonstrates the continental-scale distribution of DOM is significantly correlated with the taxonomic profile and metabolic potential of the rice paddy microbiome. Abiotic factors that have a distinct effect on community structure can also influence the chemodiversity of DOM and vice versa. Deciphering these associations and the underlying mechanisms can precipitate understanding of the complex ecology of paddy soils, as well as help assess the effects of human activities on biogeochemistry and greenhouse gas emissions in paddy soils.
  • An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel. [Journal Article]
    Nat Commun 2018; 9(1):3978Marchesi A, Gao X, … Scheuring S
  • Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction. The free energy difference of cyclic-nucleotide (cAMP/cGMP) binding/unbinding is translated into mechanical work to modulate the open/closed probability of the pore, i.e., gating. Despite the recent advances in structural determination of CNG channels, the conformational changes associated wit…
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