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(Splenomegaly)
18,893 results
  • Talaromycosis (Penicilliosis) in a Cynomolgus Macaque. [Journal Article]
  • VPVet Pathol 2018 Jan 01; :300985818758468
  • Iverson WO, Karanth S, … Nicholson SM
  • A sexually mature Chinese-origin female Macaca fascicularis assigned to the high-dose group in a 26-week toxicology study with an experimental immunomodulatory therapeutic antibody (a CD40 L antagoni...
  • Immature platelet fraction and thrombopoietin in patients with liver cirrhosis: A cohort study. [Journal Article]
  • PlosPLoS One 2018; 13(2):e0192271
  • Rauber P, Lammert F, … Appenrodt B
  • CONCLUSIONS: On closer examination of the three compartments known to have an influence on platelet count splenomegaly seems to be the major cause of thrombocytopenia in patients with cirrhosis according to current knowledge. Higher IPF% in patients with thrombocytopenia indicates peripheral consumption of platelets. The relation between spleen diameter and platelet count indicates the spleen to be the major place of platelets' consumption. TPO did not differ between patients with and without thrombocytopenia. Furthermore, we cannot exclude an influence of impaired thrombopoietin synthesis on platelet counts. The association between IPF% and platelet count suggests that there is physiological regulation of platelets in patients with cirrhosis. In our study IPF% is associated with esophageal varices and the stage of cirrhosis. Further studies are needed to confirm these results.
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