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(Stroke)
311,208 results
  • Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia. [Journal Article]
  • NLNeurosci Lett 2019 May 14
  • Hadley G, Beard DJ, … Buchan AM
  • CONCLUSIONS: AZD2014 was detrimental to neurons that underwent ischemia. AZD2014 appeared to reduce hamartin, a known neuroprotective mediator, thereby preventing any beneficial effects of mTOR inhibition. Further characterization of the role of individual mTOR complexes (mTORC1 and mTORC2) and their upstream and downstream regulators are necessary to reveal whether these pathways are neuroprotective targets for stroke.
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