- Major publications in critical care pharmacotherapy literature in 2018. [Review]
- JCJ Crit Care 2019 May 01; 52:200-207
- CONCLUSIONS: This clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.
- Genotype-guided personalization of antiplatelet treatment: A meta-analysis of patients with ACS or undergoing PCI. [Review]
- TRThromb Res 2019 May 06; 179:87-94
- CONCLUSIONS: Genotype-guided antiplatelet treatment could decrease the risks of HTPR, all-cause mortality, MI and ST in patients with ACS or undergoing PCI.
- Risk of venous and arterial thrombosis in non-surgical patients receiving systemic tranexamic acid: A systematic review and meta-analysis. [Journal Article]
- TRThromb Res 2019 May 05; 179:81-86
- CONCLUSIONS: In our systematic review and meta-analysis, the use of tranexamic acid reduced all-cause mortality without increased risk of venous or arterial thrombotic complications.
- Effects of combining modern recovery techniques with neurotrophic medication and standard treatment in stroke patients. [Journal Article]
- STSci Total Environ 2019 May 07; 679:80-87
- Stroke is the main cause of disability after age 65, leaving survivors with sequels that require care and recovery treatment lasting years. It is estimated that by the year 2030 this pathology will b…
Stroke is the main cause of disability after age 65, leaving survivors with sequels that require care and recovery treatment lasting years. It is estimated that by the year 2030 this pathology will be leading cause of mortality. To determine the efficacy of Lokomat training combined with neurotrophic medication and balneo-physiotherapeutic treatment in rehabilitation of post-stroke patients, a prospective study of 3 parallel groups was conducted: Group I (n = 22) - Lokomat, balneo-physiotherapy, and Cerebrolysin; Group II (n = 18) - Lokomat associated with balneo-physiotherapy; and Group III (n = 30) - balneo-physiotherapy alone (Control group). Patients were evaluated physically, neurologically, and functionally, according to the evolution of their motor deficiency, spasticity, functional independence and health-related quality of life. Patient improvement is significantly better (p < 0.05) in the group with associated therapies, especially during the first 6 months. Evolution was significantly better in all groups at 12 months than initially (p < 0.05), for all studied parameters and with the best effects in Group I (the three therapies combined). Association of Lokomat training with neurotrophic factors and classic recovery techniques improves the rehabilitation process in stroke patients.
- Immune system activation in perioperative thrombectomy patients: A preliminary retrospective study. [Journal Article]
- WNWorld Neurosurg 2019 May 13
- CONCLUSIONS: Overall, we found that systemic immune response has close relationships with speed of recanalization, and preliminarily may shift differently based on sex.
- Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia. [Journal Article]
- NLNeurosci Lett 2019 May 14
- CONCLUSIONS: AZD2014 was detrimental to neurons that underwent ischemia. AZD2014 appeared to reduce hamartin, a known neuroprotective mediator, thereby preventing any beneficial effects of mTOR inhibition. Further characterization of the role of individual mTOR complexes (mTORC1 and mTORC2) and their upstream and downstream regulators are necessary to reveal whether these pathways are neuroprotective targets for stroke.
- Precision, reproducibility and applicability of an undersampled multi-venc 4D flow MRI sequence for the assessment of cardiac hemodynamics. [Journal Article]
- MRMagn Reson Imaging 2019 May 14
- CONCLUSIONS: 4D Multi offers a comprehensive way to accurately quantify flow in arteries and veins both in high and low flow situations and to visualize detailed flow patterns. This technique is readily applicable in the clinical setting and has the potential to be beneficial in the clinical assessment of valvular and congenital heart diseases.
- Repurposing multiple sclerosis drugs: a review of studies in other neurological and psychiatric conditions. [Review]
- DDDrug Discov Today 2019 May 14
- Treatment options for multiple sclerosis (MS) have improved in the past 20 years, with new oral disease-modifying drugs and monoclonal antibodies becoming available. The success seen with these drugs…
Treatment options for multiple sclerosis (MS) have improved in the past 20 years, with new oral disease-modifying drugs and monoclonal antibodies becoming available. The success seen with these drugs in MS, and their various mechanisms of action, has led to them being investigated in other neurological and psychiatric disorders. This review article summarises the ongoing and completed studies of MS drugs in neurological and psychiatric conditions other than MS. The most promising results are for interferon beta in human T cell leukaemia virus 1 associated myelopathy/tropical spastic paraparesis and glioma, and for fingolimod in acute ischaemic stroke and intracerebral haemorrhage. The coming years could see the arrival of exciting new therapies for disorders that neurologists have historically found difficult to treat and that represent a significant unmet clinical need.
- Classification of Strokes in Patients Receiving Intravitreal Anti-Vascular Endothelial Growth Factor. [Journal Article]
- OSOphthalmic Surg Lasers Imaging Retina 2019 May 01; 50(5):e140-e157
- CONCLUSIONS: The authors' data suggest there is no predilection to the development of ischemic infarcts or hemorrhagic strokes in those patients receiving intravitreal anti-VEGF compared with control populations. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e140-e157.].
New Search Next
- Impact of Natural Disasters on Health Outcomes and Cancer Among Older Adults. [Journal Article]
- GGerontologist 2019 May 17; 59(Supplement_1):S50-S56
- There is growing evidence that older adults exposed to natural disasters are at disproportionate risk for adverse health events such as all-cause mortality, injury, hospital admissions, stroke, displ…
There is growing evidence that older adults exposed to natural disasters are at disproportionate risk for adverse health events such as all-cause mortality, injury, hospital admissions, stroke, displacement, cardiopulmonary distress, stress-related mental health problems, and exacerbation of chronic illnesses. Typically, analyses of the health consequences of natural disasters focus only on the populations impacted for the duration and immediate aftermath of the disaster. With few exceptions, the long-term effects of natural disasters on older adult health have not been examined. This article describes the potential consequences of exposure to natural disasters that contribute to cancer and disruption of cancer care treatment systems for older adults. It is argued that exposures to floods and wildfires in particular present an underestimated threat to the onset and/or progression of cancer and cancer care management in older adults. We propose that these impacts should be examined not only from an emergency preparedness perspective during the event but also from a public health focus that prospectively assesses risks for cancer and other health disparities. Recommendations for comprehensive longitudinal risk assessment and emergency preparedness models that address the full impact of natural disasters on the health and well-being of vulnerable, at risk, older adults are offered.